Victors

lon from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Victor ID	4924
Gene Name	lon from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Sequence Strain (Species/Organism)	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID	1251970
NCBI Protein GI	16763831
Locus Tag	STM0450
Genbank Accession	AE006468
Protein Accession	NP_459446
Taxonomy ID	700720
Gene Starting Position	505541
Gene Ending Position	507895
Gene Strand (Orientation)	+
Protein Name	DNA-binding ATP-dependent protease La
Protein pI	6.32
Protein Weight	81259.62
Protein Length	784
Protein Note	similar to Escherichia coli ATP-dependent protease La; heat shock K-protein (AAC73542.1); cleaves RcsA and SulA; heat shock K-protein; DNA binding activity
DNA Sequence	>gi\|16763390:505541-507895 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome TATGAATCCTGAGCGTTCTGAACGCATTGAAATCCCCGTATTGCCCTTGCGCGATGTGGTGGTTTATCCG CACATGGTCATACCCTTATTTGTAGGGCGGGAAAAATCTATCCGTTGTCTGGAAGCGGCTATGGACCATG ATAAAAAAATCATGCTGGTCGCCCAGAAGGAAGCATCGACGGATGAGCCGGGTGTAAACGATCTTTTCAC CGTCGGGACCGTGGCCTCTATTTTGCAGATGCTGAAACTGCCTGACGGCACCGTAAAAGTGCTGGTCGAG GGGTTACAGCGCGCGCGTATTTCCGCGCTGTCTGACAACGGCGAACATTTCTCCGCGAAGGCGGAGTACC TTGATTCGCCAGCCATTGATGAGCGTGAACAAGAAGTGCTGGTGCGTACCGCTATCAGCCAGTTCGAAGG CTACATCAAGCTGAACAAAAAAATTCCGCCGGAAGTGCTGACGTCACTCAATAGCATTGACGACCCTGCA CGTCTGGCTGACACCATCGCCGCGCATATGCCGCTGAAACTGGCGGATAAACAGTCCGTACTGGAGATGT CCGACGTTAACGAACGTCTGGAATATCTGATGGCGATGATGGAATCTGAAATCGATCTGCTGCAGGTTGA GAAACGCATTCGCAACCGCGTGAAAAAGCAGATGGAGAAATCCCAGCGCGAGTACTATCTGAACGAGCAA ATGAAAGCGATTCAGAAAGAGCTTGGCGAGATGGACGACGCGCCGGACGAAAACGAAGCGCTGAAGCGTA AGATCGACGCGGCGAAAATGCCGAAAGAGGCGAAAGAGAAAGCGGAAGCGGAACTGCAGAAGCTGAAAAT GATGTCTCCGATGTCGGCGGAAGCGACCGTGGTGCGCGGCTACATCGACTGGATGGTGCAGGTGCCGTGG AATGCGCGTAGCAAGGTCAAAAAAGACCTGCGTCAGGCGCAGGAAATCCTCGATACTGACCATTATGGTC TGGAGCGCGTGAAAGACCGCATCCTTGAGTATCTCGCGGTTCAAAGCCGTGTAAATAAAATCAAGGGGCC GATCCTGTGTCTGGTGGGGCCGCCGGGGGTAGGTAAAACCTCGTTGGGCCAGTCCATCGCTAAAGCAACA GGGCGTAAATACATCCGTATGGCGCTGGGCGGCGTGCGTGATGAAGCGGAAATCCGCGGTCATCGCCGGA CTTACATTGGCTCTATGCCGGGTAAACTGATCCAAAAAATGGCCAAAGTGGGGGTTAAAAACCCACTGTT CCTGCTCGATGAGATCGACAAAATGTCTTCTGACATGCGCGGCGATCCGGCTTCCGCACTGCTGGAAGTG CTGGATCCGGAGCAGAACGTGGCGTTCAGCGATCATTACCTGGAAGTGGATTACGATCTCAGCGATGTGA TGTTCGTCGCCACTTCCAACTCCATGAACATTCCGGCGCCGCTGCTGGATCGTATGGAAGTGATCCGTCT GTCCGGTTATACCGAAGACGAGAAGCTGAATATTGCTAAACGTCACCTGCTGCCGAAGCAGATCGAGCGT AACGCGCTGAAGAAAGGCGAACTGACGGTCGACGATAGCGCGATTATCGGTATTATCCGCTATTACACGC GTGAAGCGGGCGTGCGTAGTCTGGAGCGTGAAATCTCCAAACTGTGCCGCAAAGCGGTTAAACAACTGTT GCTCGATAAGTCGTTAAAACATATCGAAATTAACGGCGATAATCTGCACGACTACCTCGGTGTGCAGCGC TTTGATTATGGCCGCGCGGATAGCGAAAACCGCGTAGGTCAGGTGACGGGGCTGGCGTGGACGGAAGTGG GCGGCGATCTGTTGACCATCGAAACCGCCTGCGTCCCGGGCAAAGGCAAGTTGACCTACACCGGCTCGCT CGGTGAAGTGATGCAGGAATCCATTCAGGCGGCGCTGACCGTGGTGCGTGCGCGCGCGGAAAAACTGGGT ATTAATCCGGACTTTTACGAAAAACGCGATATCCACGTTCACGTGCCGGAAGGCGCAACGCCGAAAGACG GTCCAAGCGCCGGTATCGCGATGTGTACCGCGCTGGTTTCCTGCCTGACCGGTAATCCGGTGCGCGCAGA TGTGGCAATGACCGGTGAGATCACGCTGCGTGGTCAGGTGTTGCCGATCGGCGGCCTGAAAGAAAAACTG TTGGCGGCGCATCGCGGCGGGATTAAAACGGTCTTAATTCCGTTCGAAAATAAACGTGACCTGGAGGAAA TTCCGGACAACGTGATTGCCGATCTGGATATTCATCCTGTGAAGCGCATTGAGGAAGTTCTGACGCTTGC TCTGCAAAACGAACCGTCTGGAATGCAGGTTGTAACCGCAAAATA
Protein Sequence	>gi\|16763831\|ref\|NP_459446.1\| DNA-binding ATP-dependent protease La [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFT VGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEG YIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEIDLLQVE KRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMPKEAKEKAEAELQKLKM MSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGP ILCLVGPPGVGKTSLGQSIAKATGRKYIRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLF LLDEIDKMSSDMRGDPASALLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRL SGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLL LDKSLKHIEINGDNLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSL GEVMQESIQAALTVVRARAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRAD VAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLA LQNEPSGMQVVTAK
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: lon mutant is attenuated in mice (Matsui et al., 2003).
COG	COG0466O, under O: Posttranslational modification, protein turnover, chaperones
References	*Matsui et al., 2003:* Matsui H, Suzuki M, Isshiki Y, Kodama C, Eguchi M, Kikuchi Y, Motokawa K, Takaya A, Tomoyasu T, Yamamoto T. Oral immunization with ATP-dependent protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar typhimurium. Infection and immunity. 2003; 71(1); 30-39. [PubMed: 12496146].


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lon from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2