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sseJ

Victor ID 2681
Gene Name sseJ
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1253149
NCBI Protein GI 16764975
Locus Tag STM1631
Protein Accession NP_460590.1
Other Database IDs UniProtKB-ID: SSEJ_SALTY
UniRef100: UniRef100_Q9FD10
UniRef90: UniRef90_Q9FD10
UniRef50: UniRef50_Q9FD10
UniParc: UPI00000D018A
EMBL: AF294582
EMBL: AE006468
EMBL-CDS: AAG02230.1
EMBL-CDS: AAL20549.1
RefSeq_NT: NC_003197.1
GenomeReviews: AE006468_GR
KEGG: stm:STM1631
HOGENOM: HBG671276
OMA: ALECIFK
ProtClustDB: CLSK894737
BioCyc: STYP99287:STM1631-MONOMER
Taxonomy ID 99287
Gene Starting Position 1721292
Gene Ending Position 1722518
Gene Strand (Orientation) +
Protein Name secreted effector protein
DNA Sequence 
>gi|16763390:1721292-1722518 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
TATGCCATTGAGTGTTGGACAGGGTTATTTCACATCATCTATCAGTTCTGAAAAATTTAATGCGATAAAA
GAAAGCGCACGCCTTCCGGAATTAAGTTTATGGGAGAAAATCAAAGCATATTTCTTTACCACCCACCATG
CAGAGGCGCTCGAATGTATCTTTAATCTTTACCACCATCAGGAACTGAATCTAACACCGGTACAGGTTCG
CGGAGCCTACATCAAACTTCGAGCCTTAGCGTCTCAGGGATGTAAAGAACAGTTTATTATAGAATCACAG
GAACACGCCGATAAGTTGATTATTAAAGATGATAATGGTGAAAATATTTTGTCTATTGAGGTTGAATGTC
ATCCGGAAGCTTTTGGTCTTGCAAAAGAAATCAATAAATCACATCCCAAGCCCAAAAATATTTCTTTGGG
TGATATTACCAGACTGGTATTTTTTGGCGACAGCTTGTCTGACTCCTTAGGGCGTATGTTTGAAAAAACA
CATCATATCTTACCCTCCTATGGTCAATACTTTGGCGGAAGGTTTACTAATGGATTTACCTGGACTGAGT
TTTTATCATCTCCACACTTCTTAGGTAAAGAGATGCTTAATTTTGCTGAAGGGGGAAGTACATCGGCAAG
CTATTCCTGCTTTAATTGCATCGGTGACTTTGTATCAAATACGGACAGACAAGTCGCATCTTACACCCCT
TCTCACCAGGACCTGGCGATATTTTTATTGGGGGCTAATGACTATATGACACTACACAAAGATAATGTAA
TAATGGTCGTTGAGCAACAAATTGATGATATTGAAAAAATAATTTCCGGTGGAGTTAATAATGTTCTGGT
CATGGGGATTCCCGATTTGTCTTTAACACCTTATGGCAAACATTCTGATGAAAAAAGAAAGCTTAAGGAT
GAAAGCATCGCTCACAATGCCCTGTTAAAAACTAATGTTGAAGAATTAAAAGAAAAATACCCCCAGCATA
AAATATGCTATTACGAGACTGCCGATGCATTTAAGGTGATAATGGAGGCGGCCAGTAATATTGGTTATGA
TACGGAAAACCCTTATACTCACCACGGCTATGTACATGTTCCCGGGGCTAAAGACCCTCAGCTAGATATA
TGTCCGCAATACGTCTTCAACGACCTTGTCCATCCAACCCAGGAAGTCCATCATTGTTTTGCCATAATGT
TAGAAAGTTTTATAGCTCATCATTATTCCACTGAATA
Protein Sequence 
>gi|16764975|ref|NP_460590.1| secreted effector protein SseJ [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MPLSVGQGYFTSSISSEKFNAIKESARLPELSLWEKIKAYFFTTHHAEALECIFNLYHHQELNLTPVQVRGAYIKLRALASQGCKEQFIIESQEHADKLIIKDDNGENILSIEVECHPEAFGLAKEINKSHPKPKNISLGDITRLVFFGDSLSDSLGRMFEKTHHILPSYGQYFGGRFTNGFTWTEFLSSPHFLGKEMLNFAEGGSTSASYSCFNCIGDFVSNTDRQVASYTPSHQDLAIFLLGANDYMTLHKDNVIMVVEQQIDDIEKIISGGVNNVLVMGIPDLSLTPYGKHSDEKRKLKDESIAHNALLKTNVEELKEKYPQHKICYYETADAFKVIMEAASNIGYDTENPYTHHGYVHVPGAKDPQLDICPQYVFNDLVHPTQEVHHCFAIMLESFIAHHYSTE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sseJ mutants are defective in intracellular replication in cultured epithelial cells and are attenuated in mice (Ohlson et al., 2005).
COG COG3240IR, under I: Lipid transport and metabolism; R: General function prediction only
References
Ohlson et al., 2005: Ohlson MB, Fluhr K, Birmingham CL, Brumell JH, Miller SI. SseJ deacylase activity by Salmonella enterica serovar Typhimurium promotes virulence in mice. Infection and immunity. 2005; 73(10); 6249-6259. [PubMed: 16177296].