| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
spoT from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1145050
|
|
22124023
|
y0103 |
|
NP_667446.1 |
bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
purH from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1145449
|
|
22124417
|
y0502 |
|
NP_667840.1 |
AICAR formyltransferase; IMP cyclohydrolase |
Virulence factor |
MUTATION: purH mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
hfq from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1145577
|
|
22124544
|
y0630 |
|
NP_667967.1 |
RNA-binding protein Hfq |
Virulence factor |
MUTATION: hfq mutant is highly attenuated in mice after subcutaneous or intravenous injection and has attenuated survival in macrophages [Ref6386:Geng et al., 2009]. |
19593436
|
|
|
greA from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1145626
|
|
22124593
|
y0679 |
|
NP_668016.1 |
transcription elongation factor GreA |
Virulence factor |
MUTATION: greA mutants are attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
relA from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1145758
|
|
22124724
|
y0811 |
|
NP_668147.1 |
GDP/GTP pyrophosphokinase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
pcm from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1145779
|
|
22124743
|
y0832 |
|
NP_668166.1 |
protein-L-isoaspartate O-methyltransferase |
Virulence factor |
MUTATION: pcm mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
nlpD from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1145780
|
|
22124744
|
y0833 |
|
NP_668167.1 |
predicted outer membrane lipoprotein |
Virulence factor |
MUTATION: nlpD mutant is attenuated in mice [Ref6387:Tidhar et al., 2009]. |
19759820
|
|
|
purK from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1146049
|
|
22125006
|
y1102 |
|
NP_668429.1 |
AIR carboxylase, CO(2)-fixing subunit |
Virulence factor |
MUTATION: purK mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
y1136 |
Yersinia pestis KIM 10 |
1146083
|
|
22125040
|
y1136 |
AE009952 |
NP_668463 |
hypothetical protein |
Virulence factor |
MUTATION: y1136 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
pgm from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1146205
|
|
22125158
|
y1258 |
|
NP_668581.1 |
phosphoglucomutase |
Virulence factor |
MUTATION: pgm mutant of Y. pestis is attenuated in mice [Ref6388:Welkos et al., 2002]. |
12009274
|
|
|
ompX from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1146271
|
|
22125223
|
y1324 |
|
NP_668646.1 |
outer membrane protein X |
Virulence factor |
MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells [Ref6389:Kolodziejek et al., 2007]. |
17768237
|
|
|
y1436 |
Yersinia pestis KIM 10 |
1146382
|
|
22125333
|
y1436 |
AE009952 |
NP_668756 |
enzyme |
Virulence factor |
MUTATION: y1436 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
y1537 |
Yersinia pestis KIM 10 |
1146484
|
|
22125434
|
y1537 |
AE009952 |
NP_668857 |
hypothetical protein |
Virulence factor |
MUTATION: y1537 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
ompX from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1146629
|
|
22125577
|
y1682 |
|
NP_669000.1 |
outer membrane protein X |
Virulence factor |
MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells [Ref6389:Kolodziejek et al., 2007]. |
17768237
|
|
|
y1718 |
Yersinia pestis KIM 10 |
1146665
|
|
22125612
|
y1718 |
AE009952 |
NP_669035 |
hypothetical protein |
Virulence factor |
MUTATION: y1718 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
phoP from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1146741
|
|
22125688
|
y1794 |
|
NP_669111.1 |
DNA-binding response regulator in two-component regulatory system with PhoQ |
Virulence factor |
MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain [Ref6390:Oyston et al., 2000]. |
10816493
|
|
|
mgtC from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1146767
|
|
22125713
|
y1820 |
|
NP_669136.1 |
transport ATPase |
Virulence factor |
MUTATION: mgtC mutants are defective in early intracellular survival in macrophages compared to wild type Y. pestis [Ref6391:Grabenstein et al., 2006]. |
16790745
|
|
|
yfeB from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1146843
|
|
22125789
|
y1896 |
|
NP_669212.1 |
ATP-binding protein for iron and manganese ABC transporter |
Virulence factor |
MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously [Ref6392:Bearden and Perry, 1999]. |
10231495
|
|
|
yfeA from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1146844
|
|
22125790
|
y1897 |
|
NP_669213.1 |
periplasmic-binding protein for iron and manganese ABC transporter |
Virulence factor |
MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously [Ref6392:Bearden and Perry, 1999]. |
10231495
|
|
|
ompX from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1146981
|
|
22125926
|
y2034 |
|
NP_669349.1 |
outer membrane protein X |
Virulence factor |
MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells [Ref6389:Kolodziejek et al., 2007]. |
17768237
|
|
|
msbB from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1147194
|
|
22126133
|
y2247 |
|
NP_669556.1 |
lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase |
Virulence factor |
MUTATION: lpxM (msbB) mutant is avirulent in mice and guinea pigs [Ref6393:Feodorova et al., 2007]. |
17913308
|
|
|
y2285 |
Yersinia pestis KIM 10 |
1147232
|
|
22126170
|
y2285 |
AE009952 |
NP_669593 |
putative sulfate transporter YchM |
Virulence factor |
MUTATION: YchM mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
y2316 |
Yersinia pestis KIM 10 |
1147263
|
|
22126201
|
y2316 |
AE009952 |
NP_669624 |
hypothetical protein |
Virulence factor |
MUTATION: y2316 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
ybtP from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1147344
|
|
22126281
|
y2397 |
|
NP_669704.1 |
permease and ATP-binding protein of yersiniabactin-iron ABC transporter |
Virulence factor |
MUTATION: ybtP mutant is avirulent in mouse bubonic plague model [Ref6394:Fetherston et al., 1999]. |
10231486
|
|
|
irp2 from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1147346
|
|
22126283
|
y2399 |
|
NP_669706.1 |
HMWP2 nonribosomal peptide synthetase |
Virulence factor |
MUTATION: irp2 mutants are unable to grow at 37 degrees in iron deficient media [Ref6395:Fetherston et al., 1995]. |
7896707
|
|
|
psn |
Yersinia pestis KIM 10 |
1147351
|
|
22126288
|
y2404 |
|
NP_669711.1 |
pesticin/yersiniabactin outer membrane receptor |
Virulence factor |
MUTATION: psn mutant is unable to grow on iron-deficient media at 37 degrees C [Ref6395:Fetherston et al., 1995]. |
7896707
|
|
|
y2785 |
Yersinia pestis KIM 10 |
1147732
|
|
22126663
|
y2785 |
AE009952 |
NP_670086 |
hypothetical protein |
Virulence factor |
MUTATION: yadBC mutant is attenuated in mice and is less invasive of HeLa cells than the wild-type [Ref6396:Forman et al., 2008]. |
18025093
|
|
|
y2786 |
Yersinia pestis KIM 10 |
1147733
|
|
22126664
|
y2786 |
AE009952 |
NP_670087 |
hypothetical protein |
Virulence factor |
MUTATION: yadBC mutant is attenuated in mice and is less invasive of HeLa cells than the wild-type [Ref6396:Forman et al., 2008]. |
18025093
|
|
|
psaA from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1147829
|
|
22126759
|
y2882 |
|
NP_670182.1 |
pH 6 Antigen fimbrial subunit |
Virulence factor |
MUTATION: psaA mutants have a 100-fold reduced 50% lethal dose in mice [Ref6397:Lindler et al., 1990]. |
2164509
|
|
|
psaE from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1147831
|
|
22126761
|
y2884 |
|
NP_670184.1 |
regulator |
Virulence factor |
MUTATION: psaE mutants are attenuated in mice [Ref6397:Lindler et al., 1990]. |
2164509
|
|
|
y3010 |
Yersinia pestis KIM 10 |
1147957
|
|
22126887
|
y3010 |
AE009952 |
NP_670310 |
hypothetical protein |
Virulence factor |
MUTATION: y3010 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
smpB from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1148026
|
|
22126955
|
y3079 |
|
NP_670378.1 |
SsrA-binding protein |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
dnaE from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1148067
|
|
22126996
|
y3120 |
|
NP_670419.1 |
DNA polymerase III subunit alpha |
Virulence factor |
MUTATION: dnaE mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
y3395 |
Yersinia pestis KIM 10 |
1148342
|
|
22127271
|
y3395 |
AE009952 |
NP_670694 |
hypothetical protein |
Virulence factor |
MUTATION: y3395 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
thrL |
Yersinia pestis KIM 10 |
1148666
|
|
22127593
|
y3719 |
AE009952 |
NP_671016 |
thr operon leader peptide |
Virulence factor |
MUTATION: y3719 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
yapE from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1148792
|
|
22127716
|
y3845 |
|
NP_671139.1 |
autotransporter protein |
Virulence factor |
MUTATION: yapE mutant is attenuated in mice and has impaired colonization in bubonic plague model [Ref6399:Lawrenz et al., 2009]. |
18936182
|
|
|
y3857 |
Yersinia pestis KIM 10 |
1148804
|
|
22127728
|
y3857 |
AE009952 |
NP_671151 |
metalloprotease |
Virulence factor |
MUTATION: y3857 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
dam from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1148884
|
|
22127807
|
y3937 |
|
NP_671230.1 |
DNA adenine methylase |
Virulence factor |
MUTATION: dam mutant is attenuated in mice [Ref6400:Robinson et al., 2005]. |
16188402
|
|
|
crp from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1148903
|
|
22127826
|
y3956 |
|
NP_671249.1 |
cAMP-regulatory protein |
Virulence factor |
MUTATION: crp mutant is attenuated in mice [Ref6401:Sun et al., 2010]. |
20086087
|
|
|
caf1M from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149242
|
|
39980777
|
Y1098 |
|
NP_857879.2 |
F1 capsule |
Virulence factor |
MUTATION: caf1M mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
pla from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172643
|
|
16082686
|
YPPCP1.07 |
|
NP_395233.1 |
outer membrane protease |
Virulence factor |
MUTATION: pla mutant is attenuated in mice [Ref6501:Sodeinde et al., 1992]. |
1439793
|
|
|
yopE from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172651
|
|
16082697
|
YPCD1.06 |
|
NP_395143.1 |
putative outer membrane virulence protein |
Virulence factor |
MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice [Ref6502:Rosqvist et al., 1990]. |
2191183
|
|
|
yopQ from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172664
|
|
16082708
|
YPCD1.19c |
|
NP_395154.1 |
Yop targeting protein |
Virulence factor |
MUTATION: yopK mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days [Ref6503:Straley and Bowmer, 1986]. |
3002984
|
|
|
yopT from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172665
|
|
16082709
|
YPCD1.20 |
|
NP_395155.1 |
Yop targeted effector |
Virulence factor |
TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT [Ref6504:Iriarte and Cornelis, 1998]. |
9723929
|
|
|
yopM from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172671
|
|
16082715
|
YPCD1.26c |
|
NP_395161.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopM mutant is attenuated in mice compared to the wild type [Ref6505:Leung et al., 1990]. |
2401564
|
|
|
yopD from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172673
|
|
16082716
|
YPCD1.28c |
|
NP_395162.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells [Ref6506:Rosqvist et al., 1991]. |
1937815
|
|
|
yopB from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172674
|
|
16082717
|
YPCD1.29c |
|
NP_395163.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells [Ref6507:HÃ¥kansson et al., 1996]. |
8918459
|
|
|
sycD from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172675
|
|
16082718
|
YPCD1.30c |
|
NP_395164.1 |
secretion chaperone |
Virulence factor |
MUTATION: lcrH mutant is avirulent in mice [Ref6508:Price and Straley, 1989]. |
2707857
|
|
|
lcrV from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172676
|
|
16082719
|
YPCD1.31c |
|
NP_395165.1 |
secreted effector protein |
Virulence factor |
MUTATION: lcrV mutants are avirulent in mice [Ref6509:Skrzypek and Straley, 1995]. |
7730287
|
|
|
virF from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172694
|
|
16082737
|
YPCD1.49 |
|
NP_395183.1 |
transcriptional regulator |
Virulence factor |
MUTATION: lcrF mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
yopH from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172712
|
|
16082755
|
YPCD1.67c |
|
NP_395201.1 |
putative secreted protein-tyrosine phosphatase |
Virulence factor |
MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis [Ref6510:Andersson et al., 1996]. |
8809758
|
|
|
ypkA from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172717
|
|
16082760
|
YPCD1.72c |
|
NP_395206.1 |
secreted protein kinase |
Virulence factor |
MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice [Ref6511:Galyov et al., 1993]. |
8441468
|
|
|
caf1M from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172837
|
|
16082874
|
YPMT1.82 |
|
NP_395428.1 |
putative F1 chaperone protein |
Virulence factor |
MUTATION: caf1M mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
caf1A from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172838
|
|
16082875
|
YPMT1.83 |
|
NP_395429.1 |
putative F1 capsule anchoring protein |
Virulence factor |
MUTATION: caf1A mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
spoT from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1172888
|
|
16120391
|
YPO0038 |
|
NP_403704.1 |
bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
dam from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1173000
|
|
16120497
|
YPO0154 |
|
NP_403810.1 |
DNA adenine methylase |
Virulence factor |
MUTATION: dam mutant is attenuated in mice [Ref6400:Robinson et al., 2005]. |
16188402
|
|
|
crp from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1173020
|
|
16120516
|
YPO0175 |
|
NP_403829.1 |
cAMP-regulatory protein |
Virulence factor |
MUTATION: crp mutant is attenuated in mice [Ref6401:Sun et al., 2010]. |
20086087
|
|
|
hfq from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1173219
|
|
16120708
|
YPO0373 |
|
NP_404021.1 |
RNA-binding protein Hfq |
Virulence factor |
MUTATION: hfq mutant is highly attenuated in mice after subcutaneous or intravenous injection and has attenuated survival in macrophages [Ref6386:Geng et al., 2009]. |
19593436
|
|
|
arcA |
Yersinia pestis CO92 |
1173302
|
|
218927655
|
YPO0458 |
AL590842 |
YP_002345530 |
two-component response regulator |
Virulence factor |
MUTATION: arcA mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
YPO1003 |
Yersinia pestis CO92 |
1173841
|
|
218928173
|
YPO1003 |
AL590842 |
YP_002346048 |
hypothetical protein |
Virulence factor |
MUTATION: YPO1003 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
dnaE from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1173899
|
|
16121359
|
YPO1059 |
|
NP_404672.1 |
DNA polymerase III subunit alpha |
Virulence factor |
MUTATION: dnaE mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
ssrA from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1173948
|
|
0
|
YPOs04 |
|
- |
misc_RNA |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
smpB from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1173949
|
|
16121401
|
YPO1101 |
|
NP_404714.1 |
SsrA-binding protein |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
YPO1179 |
Yersinia pestis CO92 |
1174028
|
|
218928342
|
YPO1179 |
AL590842 |
YP_002346217 |
hypothetical protein |
Virulence factor |
MUTATION: YPO1179 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
psaE from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1174143
|
|
16121583
|
YPO1301 |
|
NP_404896.1 |
putative regulatory protein |
Virulence factor |
MUTATION: psaE mutants are attenuated in mice [Ref6397:Lindler et al., 1990]. |
2164509
|
|
|
psaA from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1174145
|
|
16121585
|
YPO1303 |
|
NP_404898.1 |
pH 6 antigen precursor (antigen 4) (adhesin) |
Virulence factor |
MUTATION: psaA mutants have a 100-fold reduced 50% lethal dose in mice [Ref6397:Lindler et al., 1990]. |
2164509
|
|
|
YPO1387 |
Yersinia pestis CO92 |
1174228
|
|
218928535
|
YPO1387 |
AL590842 |
YP_002346410 |
hypothetical protein |
Virulence factor |
MUTATION: yadBC mutant (yadB is YPO1387) is attenuated in mice and is less invasive to HeLa cells than the wildtype [Ref6396:Forman et al., 2008]. |
18025093
|
|
|
YPO1388 |
Yersinia pestis CO92 |
1174229
|
|
218928536
|
YPO1388 |
AL590842 |
YP_002346411 |
hypothetical protein |
Virulence factor |
MUTATION: yadBC (yadC is YPO1388) mutant is attenuated in mice and is less invasive of HeLa cells than the wild-type [Ref6396:Forman et al., 2008]. |
18025093
|
|
|
phoP from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1174473
|
|
16121902
|
YPO1634 |
|
NP_405215.1 |
DNA-binding response regulator in two-component regulatory system with PhoQ |
Virulence factor |
MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain [Ref6390:Oyston et al., 2000]. |
10816493
|
|
|
mgtC from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1174499
|
|
16121925
|
YPO1660 |
|
NP_405238.1 |
Mg(2+) transport ATPase protein C |
Virulence factor |
MUTATION: mgtC mutants are defective in early intracellular survival in macrophages compared to wild type Y. pestis [Ref6391:Grabenstein et al., 2006]. |
16790745
|
|
|
ail |
Yersinia pestis CO92 |
1174696
|
|
218928979
|
YPO1860 |
AL590842 |
YP_002346854 |
attachment invasion locus protein |
Virulence factor |
MUTATION: a Y. pestis ail deletion mutant was rapidly killed by sera from all mammals tested except mice [Ref6512:Bartra et al., 2008]. |
18025094
|
|
|
fyuA from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1174745
|
|
16122154
|
YPO1906 |
|
NP_405467.1 |
pesticin/yersiniabactin receptor protein |
Virulence factor |
MUTATION: psn mutant is unable to grow on iron-deficient media at 37 degrees C [Ref6395:Fetherston et al., 1995]. |
7896707
|
|
|
irp2 from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1174750
|
|
16122159
|
YPO1911 |
|
NP_405472.1 |
yersiniabactin biosynthetic protein |
Virulence factor |
MUTATION: irp2 mutants are unable to grow at 37 degrees in iron deficient media [Ref6395:Fetherston et al., 1995]. |
7896707
|
|
|
ybtP from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1174752
|
|
16122161
|
YPO1913 |
|
NP_405474.1 |
lipoprotein inner membrane ABC-transporter |
Virulence factor |
MUTATION: ybtP mutant is avirulent in mouse bubonic plague model [Ref6394:Fetherston et al., 1999]. |
10231486
|
|
|
YPO1994 |
Yersinia pestis CO92 |
1174831
|
|
218929104
|
YPO1994 |
AL590842 |
YP_002346979 |
hypothetical protein |
Virulence factor |
MUTATION: YPO1994 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
YPO2027 |
Yersinia pestis CO92 |
1174861
|
|
0
|
YPO2027 |
|
- |
pseudo |
Virulence factor |
MUTATION: YPO2027 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
msbB from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1174901
|
|
16122302
|
YPO2063 |
|
NP_405615.1 |
lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase |
Virulence factor |
MUTATION: lpxM (msbB) mutant is avirulent in mice and guinea pigs [Ref6393:Feodorova et al., 2007]. |
17913308
|
|
|
ail from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1175024
|
|
16122420
|
YPO2190 |
|
NP_405733.1 |
attachment invasion locus protein precursor |
Virulence factor |
MUTATION: a Y. pestis ail deletion mutant was rapidly killed by sera from all mammals tested except mice [Ref6512:Bartra et al., 2008]. |
18025094
|
|
|
slyA |
Yersinia pestis CO92 |
1175206
|
|
16122597
|
YPO2374 |
|
NP_405910.1 |
transcriptional regulator SlyA |
Virulence factor |
MUTATION: slyA (rovA) mutant is attenuated in mice [Ref6513:Cathelyn et al., 2006]. |
16938880
|
|
|
lpp from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1175228
|
|
16122617
|
YPO2394 |
|
NP_405930.1 |
major outer membrane lipoprotein |
Virulence factor |
MUTATION: lpp deletion mutant is attenuated in mice [Ref6514:Liu et al., 2010]. |
19737605
|
|
|
yfeA from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1175273
|
|
16122660
|
YPO2439 |
|
NP_405973.1 |
periplasmic-binding protein |
Virulence factor |
MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously [Ref6392:Bearden and Perry, 1999]. |
10231495
|
|
|
yfeB from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1175274
|
|
16122661
|
YPO2440 |
|
NP_405974.1 |
ATP-binding transport protein |
Virulence factor |
MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously [Ref6392:Bearden and Perry, 1999]. |
10231495
|
|
|
YPO2471 |
Yersinia pestis CO92 |
1175305
|
|
218929560
|
YPO2471 |
AL590842 |
YP_002347435 |
hypothetical protein |
Virulence factor |
MUTATION: YPO2471 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
ompX from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1175340
|
|
16122727
|
YPO2506 |
|
NP_406040.1 |
outer membrane protein X |
Virulence factor |
MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells [Ref6389:Kolodziejek et al., 2007]. |
17768237
|
|
|
pgm from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1175516
|
|
16122891
|
YPO2686 |
|
NP_406204.1 |
phosphoglucomutase |
Virulence factor |
MUTATION: pgm mutant of Y. pestis is attenuated in mice [Ref6388:Welkos et al., 2002]. |
12009274
|
|
|
YPO2793 |
Yersinia pestis CO92 |
1175620
|
|
218929860
|
YPO2793 |
AL590842 |
YP_002347735 |
hypothetical protein |
Virulence factor |
MUTATION: YPO2793 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
guaA |
Yersinia pestis CO92 |
1175694
|
|
16123062
|
YPO2870 |
|
NP_406375.1 |
bifunctional GMP synthase/glutamine amidotransferase protein |
Virulence factor |
MUTATION: guaBA operon mutant is highly attenuated in mice [Ref6515:Oyston et al., 2010]. |
20096773
|
|
|
guaB |
Yersinia pestis CO92 |
1175695
|
|
16123063
|
YPO2871 |
|
NP_406376.1 |
inositol-5-monophosphate dehydrogenase |
Virulence factor |
MUTATION: guaBA operon mutant is highly attenuated in mice [Ref6515:Oyston et al., 2010]. |
20096773
|
|
|
ail from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1175729
|
|
16123096
|
YPO2905 |
|
NP_406409.1 |
attachment invasion locus protein |
Virulence factor |
MUTATION: a Y. pestis ail deletion mutant was rapidly killed by sera from all mammals tested except mice [Ref6512:Bartra et al., 2008]. |
18025094
|
|
|
YPO2947 |
Yersinia pestis CO92 |
1175766
|
|
16123130
|
YPO2947 |
|
NP_406443.1 |
hypothetical protein |
Virulence factor |
MUTATION: YPO2947 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
YPO3045 |
Yersinia pestis CO92 |
1175866
|
|
16123222
|
YPO3045 |
|
NP_406535.1 |
hypothetical protein |
Virulence factor |
MUTATION: YP03045 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
purK from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1175898
|
|
16123254
|
YPO3077 |
|
NP_406567.1 |
phosphoribosylaminoimidazole carboxylase ATPase subunit |
Virulence factor |
MUTATION: purK mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
nlpD from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1176173
|
|
16123506
|
YPO3356 |
|
NP_406819.1 |
predicted outer membrane lipoprotein |
Virulence factor |
MUTATION: nlpD mutant is attenuated in mice [Ref6387:Tidhar et al., 2009]. |
19759820
|
|
|
pcm from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1176174
|
|
16123507
|
YPO3357 |
|
NP_406820.1 |
protein-L-isoaspartate O-methyltransferase |
Virulence factor |
MUTATION: pcm mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
relA from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1176197
|
|
16123529
|
YPO3380 |
|
NP_406842.1 |
GDP/GTP pyrophosphokinase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
YPO3398 |
Yersinia pestis CO92 |
1176215
|
|
16123547
|
YPO3398 |
|
NP_406860.1 |
glutamyl-Q tRNA(Asp) synthetase |
Virulence factor |
MUTATION: yadBC double mutant is less invasive of HeLa cells compared to the wild type and decreased virulence in bubonic plague in mice [Ref6396:Forman et al., 2008]. |
18025093
|
|
|
greA from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1176324
|
|
16123651
|
YPO3505 |
|
NP_406964.1 |
transcription elongation factor GreA |
Virulence factor |
MUTATION: greA mutants are attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
purH from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1176554
|
|
16123865
|
YPO3728 |
|
NP_407178.1 |
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase |
Virulence factor |
MUTATION: purH mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
YPO3973 |
Yersinia pestis CO92 |
1176811
|
|
16124100
|
YPO3973 |
|
NP_407413.1 |
metalloprotease |
Virulence factor |
MUTATION: YPO3973 mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
yapE from Yersinia pestis CO92 |
Yersinia pestis CO92 |
1176822
|
|
16124111
|
YPO3984 |
|
NP_407424.1 |
putative autotransporter protein |
Virulence factor |
MUTATION: yapE mutant is attenuated in mice and has impaired colonization in bubonic plague model [Ref6399:Lawrenz et al., 2009]. |
18936182
|
|
|
purH from Yersinia pestis Antiqua |
Yersinia pestis Antiqua |
4118909
|
|
108809592
|
YPA_3601 |
|
YP_653508.1 |
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase |
Virulence factor |
MUTATION: purH mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
relA from Yersinia pestis Antiqua |
Yersinia pestis Antiqua |
4120004
|
|
108808868
|
YPA_2877 |
|
YP_652784.1 |
GDP/GTP pyrophosphokinase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
greA from Yersinia pestis Antiqua |
Yersinia pestis Antiqua |
4121636
|
|
108806053
|
YPA_0055 |
|
YP_649969.1 |
transcription elongation factor GreA |
Virulence factor |
MUTATION: greA mutants are attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
pcm from Yersinia pestis Antiqua |
Yersinia pestis Antiqua |
4122242
|
|
108808777
|
YPA_2786 |
|
YP_652693.1 |
protein-L-isoaspartate O-methyltransferase |
Virulence factor |
MUTATION: pcm mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
ssrA from Yersinia pestis Antiqua |
Yersinia pestis Antiqua |
4122330
|
|
0
|
YPA_r031 |
|
- |
tmRNA |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
smpB from Yersinia pestis Antiqua |
Yersinia pestis Antiqua |
4122331
|
|
108806576
|
YPA_0579 |
|
YP_650492.1 |
SsrA-binding protein |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
smpB from Yersinia pestis Nepal516 |
Yersinia pestis Nepal516 |
4123391
|
|
108813057
|
YPN_2897 |
|
YP_648824.1 |
SsrA-binding protein |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
ssrA from Yersinia pestis Nepal516 |
Yersinia pestis Nepal516 |
4123392
|
|
0
|
YPN_r084 |
|
- |
tmRNA |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
relA from Yersinia pestis Nepal516 |
Yersinia pestis Nepal516 |
4123547
|
|
108810878
|
YPN_0713 |
|
YP_646645.1 |
GDP/GTP pyrophosphokinase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
purH from Yersinia pestis Nepal516 |
Yersinia pestis Nepal516 |
4124166
|
|
108810403
|
YPN_0237 |
|
YP_646170.1 |
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase |
Virulence factor |
MUTATION: purH mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
pcm from Yersinia pestis Nepal516 |
Yersinia pestis Nepal516 |
4124797
|
|
108810901
|
YPN_0736 |
|
YP_646668.1 |
protein-L-isoaspartate O-methyltransferase |
Virulence factor |
MUTATION: pcm mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
ompX from Yersinia pestis Nepal516 |
Yersinia pestis Nepal516 |
4125180
|
|
108812262
|
YPN_2100 |
|
YP_648029.1 |
outer membrane protein X |
Virulence factor |
MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells [Ref6389:Kolodziejek et al., 2007]. |
17768237
|
|
|
greA from Yersinia pestis Nepal516 |
Yersinia pestis Nepal516 |
4125871
|
|
108813409
|
YPN_3249 |
|
YP_649176.1 |
transcription elongation factor GreA |
Virulence factor |
MUTATION: greA mutants are attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
greA from Yersinia pestis Pestoides F |
Yersinia pestis Pestoides F |
5062094
|
|
145600801
|
YPDSF_3554 |
|
YP_001164877.1 |
transcription elongation factor GreA |
Virulence factor |
MUTATION: greA mutants are attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
relA from Yersinia pestis Pestoides F |
Yersinia pestis Pestoides F |
5062871
|
|
145600237
|
YPDSF_2980 |
|
YP_001164313.1 |
GDP/GTP pyrophosphokinase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
pcm from Yersinia pestis Pestoides F |
Yersinia pestis Pestoides F |
5062894
|
|
145600260
|
YPDSF_3003 |
|
YP_001164336.1 |
protein-L-isoaspartate O-methyltransferase |
Virulence factor |
MUTATION: pcm mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
purH from Yersinia pestis Pestoides F |
Yersinia pestis Pestoides F |
5063065
|
|
145600973
|
YPDSF_3726 |
|
YP_001165049.1 |
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase |
Virulence factor |
MUTATION: purH mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
smpB from Yersinia pestis Pestoides F |
Yersinia pestis Pestoides F |
5063531
|
|
145599861
|
YPDSF_2596 |
|
YP_001163937.1 |
SsrA-binding protein |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
ssrA from Yersinia pestis Pestoides F |
Yersinia pestis Pestoides F |
5063532
|
|
0
|
YPDSF_R0054 |
|
- |
tmRNA |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
ompX from Yersinia pestis Pestoides F |
Yersinia pestis Pestoides F |
5064369
|
|
145599198
|
YPDSF_1918 |
|
YP_001163274.1 |
outer membrane protein X |
Virulence factor |
MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells [Ref6389:Kolodziejek et al., 2007]. |
17768237
|
|
|
yscH from Yersinia pestis Angola |
Yersinia pestis Angola |
5798229
|
|
162417765
|
YpAngola_B0059 |
|
YP_001604490.1 |
type III secretion protein YopR |
Virulence factor |
MUTATION: The LD50 for the mouse of the yscH mutant was 10-fold higher than that of the parental strain indicating that YopR is involved in pathogenesis [Ref6610:Allaoui et al., 1995]. |
8709853
|
|
|
yopK from Yersinia pestis Angola |
Yersinia pestis Angola |
5798230
|
|
162417795
|
YpAngola_B0015 |
|
YP_001604448.1 |
YopK protein |
Virulence factor |
MUTATION: yopK mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days [Ref6503:Straley and Bowmer, 1986]. |
3002984
|
|
|
lcrH from Yersinia pestis Angola |
Yersinia pestis Angola |
5798234
|
|
162417760
|
YpAngola_B0031 |
|
YP_001604462.1 |
type III secretion low calcium response chaperone LcrH |
Virulence factor |
MUTATION: lcrH mutant is avirulent in mice [Ref6508:Price and Straley, 1989]. |
2707857
|
|
|
lcrF from Yersinia pestis Angola |
Yersinia pestis Angola |
5798258
|
|
162417806
|
YpAngola_B0050 |
|
YP_001604481.1 |
thermoregulatory protein LcrF |
Virulence factor |
MUTATION: lcrF mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
yopE from Yersinia pestis Angola |
Yersinia pestis Angola |
5798272
|
|
162417742
|
YpAngola_B0003 |
|
YP_001604439.1 |
outer membrane virulence protein YopE |
Virulence factor |
MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice [Ref6502:Rosqvist et al., 1990]. |
2191183
|
|
|
yopH from Yersinia pestis Angola |
Yersinia pestis Angola |
5798273
|
|
162417751
|
YpAngola_B0067 |
|
YP_001604497.1 |
protein-tyrosine-phosphatase YopH |
Virulence factor |
MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis [Ref6510:Andersson et al., 1996]. |
8809758
|
|
|
yopB from Yersinia pestis Angola |
Yersinia pestis Angola |
5798275
|
|
162417812
|
YpAngola_B0030 |
|
YP_001604461.1 |
translocator protein YopB |
Virulence factor |
MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells [Ref6507:HÃ¥kansson et al., 1996]. |
8918459
|
|
|
yopM from Yersinia pestis Angola |
Yersinia pestis Angola |
5798276
|
|
162417819
|
YpAngola_B0025 |
|
YP_001604457.1 |
effector protein YopM |
Virulence factor |
MUTATION: yopM mutant is attenuated in mice compared to the wild type [Ref6505:Leung et al., 1990]. |
2401564
|
|
|
yopT from Yersinia pestis Angola |
Yersinia pestis Angola |
5798299
|
|
162417779
|
YpAngola_B0016 |
|
YP_001604449.1 |
cysteine protease YopT |
Virulence factor |
TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT [Ref6504:Iriarte and Cornelis, 1998]. |
9723929
|
|
|
yopD from Yersinia pestis Angola |
Yersinia pestis Angola |
5798303
|
|
162417734
|
YpAngola_B0029 |
|
YP_001604460.1 |
translocator protein YopD |
Virulence factor |
MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells [Ref6506:Rosqvist et al., 1991]. |
1937815
|
|
|
lcrV from Yersinia pestis Angola |
Yersinia pestis Angola |
5798320
|
|
162417744
|
YpAngola_B0032 |
|
YP_001604463.1 |
virulence-associated V antigen LcrV |
Virulence factor |
MUTATION: lcrV mutants are avirulent in mice [Ref6509:Skrzypek and Straley, 1995]. |
7730287
|
|
|
pla from Yersinia pestis Angola |
Yersinia pestis Angola |
5798447
|
|
162417902
|
YpAngola_0009 |
|
YP_001604531.1 |
plasminogen activator Pla |
Virulence factor |
MUTATION: pla mutant is attenuated in mice [Ref6501:Sodeinde et al., 1992]. |
1439793
|
|
|
pla from Yersinia pestis Angola |
Yersinia pestis Angola |
5798450
|
|
162417870
|
YpAngola_0023 |
|
YP_001604542.1 |
plasminogen activator Pla |
Virulence factor |
MUTATION: pla mutant is attenuated in mice [Ref6501:Sodeinde et al., 1992]. |
1439793
|
|
|
spoT from Yersinia pestis Angola |
Yersinia pestis Angola |
5798508
|
|
162419160
|
YpAngola_A0043 |
|
YP_001604684.1 |
guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
ail from Yersinia pestis Angola |
Yersinia pestis Angola |
5798908
|
|
162418778
|
YpAngola_A0444 |
|
YP_001605049.1 |
attachment invasion locus protein |
Virulence factor |
MUTATION: a Y. pestis ail deletion mutant was rapidly killed by sera from all mammals tested except mice [Ref6512:Bartra et al., 2008]. |
18025094
|
|
|
purH from Yersinia pestis Angola |
Yersinia pestis Angola |
5798929
|
|
162419129
|
YpAngola_A0465 |
|
YP_001605070.1 |
bifunctional purine biosynthesis protein PurH |
Virulence factor |
MUTATION: purH mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
pcm from Yersinia pestis Angola |
Yersinia pestis Angola |
5799423
|
|
162418533
|
YpAngola_A0960 |
|
YP_001605524.1 |
protein-L-isoaspartate O-methyltransferase |
Virulence factor |
MUTATION: pcm mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
relA from Yersinia pestis Angola |
Yersinia pestis Angola |
5799446
|
|
162418825
|
YpAngola_A0983 |
|
YP_001605545.1 |
GTP pyrophosphokinase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
purK from Yersinia pestis Angola |
Yersinia pestis Angola |
5799740
|
|
162419683
|
YpAngola_A1274 |
|
YP_001605809.1 |
phosphoribosylaminoimidazole carboxylase, ATPase subunit |
Virulence factor |
MUTATION: purK mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
ssrA from Yersinia pestis Angola |
Yersinia pestis Angola |
5799838
|
|
0
|
YpAngola_A4223 |
|
- |
tmRNA |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
smpB from Yersinia pestis Angola |
Yersinia pestis Angola |
5799839
|
|
162421221
|
YpAngola_A1372 |
|
YP_001605898.1 |
SsrA-binding protein |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
ompX from Yersinia pestis Angola |
Yersinia pestis Angola |
5800238
|
|
162418882
|
YpAngola_A1767 |
|
YP_001606256.1 |
outer membrane protein X |
Virulence factor |
MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells [Ref6389:Kolodziejek et al., 2007]. |
17768237
|
|
|
fyuA from Yersinia pestis Angola |
Yersinia pestis Angola |
5800563
|
|
162421186
|
YpAngola_A2093 |
|
YP_001606551.1 |
yersiniabactin/pesticin receptor FyuA |
Virulence factor |
MUTATION: psn (fyuA) mutant is unable to grow on iron-deficient media at 37 degrees C [Ref6395:Fetherston et al., 1995]. |
7896707
|
|
|
irp2 from Yersinia pestis Angola |
Yersinia pestis Angola |
5800568
|
|
162419029
|
YpAngola_A2098 |
|
YP_001606556.1 |
yersiniabactin synthetase, HMWP2 component |
Virulence factor |
MUTATION: irp2 mutants are unable to grow at 37 degrees in iron deficient media [Ref6395:Fetherston et al., 1995]. |
7896707
|
|
|
ybtP from Yersinia pestis Angola |
Yersinia pestis Angola |
5800570
|
|
162421511
|
YpAngola_A2100 |
|
YP_001606558.1 |
yersiniabactin ABC transporter, ATP-binding/permease protein |
Virulence factor |
MUTATION: ybtP mutant is avirulent in mouse bubonic plague model [Ref6394:Fetherston et al., 1999]. |
10231486
|
|
|
lpp from Yersinia pestis Angola |
Yersinia pestis Angola |
5801054
|
|
162419719
|
YpAngola_A2583 |
|
YP_001606992.1 |
major outer membrane lipoprotein |
Virulence factor |
MUTATION: lpp deletion mutant is attenuated in mice [Ref6514:Liu et al., 2010]. |
19737605
|
|
|
yfeA from Yersinia pestis Angola |
Yersinia pestis Angola |
5801102
|
|
162419227
|
YpAngola_A2630 |
|
YP_001607037.1 |
chelated iron ABC transporter, periplasmic iron binding protein YfeA |
Virulence factor |
MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously [Ref6392:Bearden and Perry, 1999]. |
10231495
|
|
|
yfeB from Yersinia pestis Angola |
Yersinia pestis Angola |
5801103
|
|
162419654
|
YpAngola_A2631 |
|
YP_001607038.1 |
chelated iron ABC transporter, ATP-binding protein YfeB |
Virulence factor |
MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously [Ref6392:Bearden and Perry, 1999]. |
10231495
|
|
|
phoP from Yersinia pestis Angola |
Yersinia pestis Angola |
5801327
|
|
162418657
|
YpAngola_A2855 |
|
YP_001607237.1 |
transcriptional regulatory protein PhoP |
Virulence factor |
MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain [Ref6390:Oyston et al., 2000]. |
10816493
|
|
|
pgm from Yersinia pestis Angola |
Yersinia pestis Angola |
5802050
|
|
162420967
|
YpAngola_A3574 |
|
YP_001607899.1 |
phosphoglucomutase, alpha-D-glucose phosphate-specific |
Virulence factor |
MUTATION: pgm mutant of Y. pestis is attenuated in mice [Ref6388:Welkos et al., 2002]. |
12009274
|
|
|
crp from Yersinia pestis Angola |
Yersinia pestis Angola |
5802179
|
|
162420734
|
YpAngola_A3702 |
|
YP_001608021.1 |
catabolite gene activator |
Virulence factor |
MUTATION: crp mutant is attenuated in mice [Ref6401:Sun et al., 2010]. |
20086087
|
|
|
greA from Yersinia pestis Angola |
Yersinia pestis Angola |
5802460
|
|
162421747
|
YpAngola_A3982 |
|
YP_001608277.1 |
transcription elongation factor GreA |
Virulence factor |
MUTATION: greA mutants are attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
ymt from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236150
|
|
149192814
|
YPE_4333 |
|
YP_001294045.1 |
murine toxin |
Virulence factor |
MUTATION: ymt mutants are unable to block X. cheopsis fleas and have low survival rates in the flea gut [Ref6611:Hinnebusch et al., 2002]. |
11976454
|
|
|
caf1M from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236158
|
|
149192807
|
YPE_4324 |
|
YP_001294038.1 |
putative F1 chaperone protein |
Virulence factor |
MUTATION: caf1M mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
caf1A from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236159
|
|
149192806
|
YPE_4323 |
|
YP_001294037.1 |
putative F1 capsule anchoring protein |
Virulence factor |
MUTATION: caf1A mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
yopK from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236061
|
|
149192717
|
YPE_4233 |
|
YP_001293949.1 |
secreted targeting protein, possible regulator, Type III system |
Virulence factor |
MUTATION: yopK mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days [Ref6503:Straley and Bowmer, 1986]. |
3002984
|
|
|
yopT from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236062
|
|
149192716
|
YPE_4232 |
|
YP_001293948.1 |
Translocated cysteine protease/Rho GTPase toxin |
Virulence factor |
TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT [Ref6504:Iriarte and Cornelis, 1998]. |
9723929
|
|
|
yopM from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236067
|
|
149192712
|
YPE_4227 |
|
YP_001293944.1 |
leucine-rich 15-repeat translocated effector protein |
Virulence factor |
MUTATION: yopM mutant is attenuated in mice compared to the wild type [Ref6505:Leung et al., 1990]. |
2401564
|
|
|
yopD from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236068
|
|
149192711
|
YPE_4226 |
|
YP_001293943.1 |
putative secreted pore/translocation protein |
Virulence factor |
MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells [Ref6506:Rosqvist et al., 1991]. |
1937815
|
|
|
yopB from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236069
|
|
149192710
|
YPE_4225 |
|
YP_001293942.1 |
putative secreted pore/translocation protein |
Virulence factor |
MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells [Ref6507:HÃ¥kansson et al., 1996]. |
8918459
|
|
|
lcrH from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236070
|
|
149192709
|
YPE_4224 |
|
YP_001293941.1 |
putative yopB/yopD chaperone |
Virulence factor |
MUTATION: lcrH mutant is avirulent in mice [Ref6508:Price and Straley, 1989]. |
2707857
|
|
|
lcrV from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236071
|
|
149192708
|
YPE_4223 |
|
YP_001293940.1 |
V antigen |
Virulence factor |
MUTATION: lcrV mutants are avirulent in mice [Ref6509:Skrzypek and Straley, 1995]. |
7730287
|
|
|
lcrF from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236089
|
|
149192690
|
YPE_4205 |
|
YP_001293922.1 |
putative thermoregulatory protein |
Virulence factor |
MUTATION: lcrF mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
yscH from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236097
|
|
149192682
|
YPE_4197 |
|
YP_001293914.1 |
type III secreted virulence protein |
Virulence factor |
MUTATION: The LD50 for the mouse of the yscH mutant was 10-fold higher than that of the parental strain indicating that YopR is involved in pathogenesis [Ref6610:Allaoui et al., 1995]. |
8709853
|
|
|
yopH from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236107
|
|
149192673
|
YPE_4187 |
|
YP_001293905.1 |
translocated protein-tyrosine kinase, inhibitor of phagocytosis |
Virulence factor |
MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis [Ref6510:Andersson et al., 1996]. |
8809758
|
|
|
ypkA from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236112
|
|
149192671
|
YPE_4182 |
|
YP_001293903.1 |
Protein kinase, host Rho GTPase toxin |
Virulence factor |
MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice [Ref6511:Galyov et al., 1993]. |
8441468
|
|
|
yopE from Yersinia pestis CA88-4125 |
Yersinia pestis CA88-4125 |
5236139
|
|
149192652
|
YPE_4152 |
|
YP_001293884.1 |
Translocated host-GTPase-activating protein |
Virulence factor |
MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice [Ref6502:Rosqvist et al., 1990]. |
2191183
|
|
|
ymt from Yersinia pestis |
Yersinia pestis |
3077319
|
|
52788173
|
pG8786_122 |
|
YP_094001.1 |
toxin protein |
Virulence factor |
MUTATION: ymt mutants are unable to block X. cheopsis fleas and have low survival rates in the flea gut [Ref6611:Hinnebusch et al., 2002]. |
11976454
|
|
|
caf1A from Yersinia pestis |
Yersinia pestis |
3077339
|
|
52788125
|
pG8786_073 |
|
YP_093953.1 |
F1 capsule anchoring protein |
Virulence factor |
MUTATION: caf1A mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
caf1M from Yersinia pestis |
Yersinia pestis |
3077340
|
|
52788126
|
pG8786_074 |
|
YP_093954.1 |
F1 capsule protein |
Virulence factor |
MUTATION: caf1M mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
caf1M from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767618
|
|
45478669
|
YP_pMT084 |
|
NP_995525.1 |
putative F1 chaperone protein |
Virulence factor |
MUTATION: caf1M mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
caf1A from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767657
|
|
45478668
|
YP_pMT083 |
|
NP_995524.1 |
putative F1 capsule anchoring protein |
Virulence factor |
MUTATION: caf1A mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
ymt from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767661
|
|
45478703
|
YP_pMT119 |
|
NP_995559.1 |
murine toxin |
Virulence factor |
MUTATION: ymt mutants are unable to block X. cheopsis fleas and have low survival rates in the flea gut [Ref6611:Hinnebusch et al., 2002]. |
11976454
|
|
|
sycD from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767486
|
|
45478554
|
YP_pCD53 |
|
NP_995381.1 |
putative yopB/yopD chaperone SycD |
Virulence factor |
MUTATION: lcrH (sycD) mutant is avirulent in mice [Ref6508:Price and Straley, 1989]. |
2707857
|
|
|
yopB from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767487
|
|
45478555
|
YP_pCD54 |
|
NP_995382.1 |
putative Yop targeting protein YopB |
Virulence factor |
MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells [Ref6507:HÃ¥kansson et al., 1996]. |
8918459
|
|
|
yopD from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767507
|
|
45478556
|
YP_pCD55 |
|
NP_995383.1 |
putative Yop negative regulation/targeting component YopD |
Virulence factor |
MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells [Ref6506:Rosqvist et al., 1991]. |
1937815
|
|
|
yopT from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767512
|
|
45478564
|
YP_pCD67 |
|
NP_995391.1 |
putative cytotoxic effector protein YopT |
Virulence factor |
TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT [Ref6504:Iriarte and Cornelis, 1998]. |
9723929
|
|
|
yopH from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767526
|
|
45478518
|
YP_pCD17 |
|
NP_995345.1 |
putative protein-tyrosine phosphatase Yop effector YopH |
Virulence factor |
MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis [Ref6510:Andersson et al., 1996]. |
8809758
|
|
|
lcrV from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767532
|
|
45478553
|
YP_pCD52 |
|
NP_995380.1 |
V antigen LcrV |
Virulence factor |
MUTATION: lcrV mutants are avirulent in mice [Ref6509:Skrzypek and Straley, 1995]. |
7730287
|
|
|
yopQ from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767553
|
|
45478565
|
YP_pCD68 |
|
NP_995392.1 |
putative virulence determinant protein YopQ |
Virulence factor |
MUTATION: yopK (yopQ) mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days [Ref6503:Straley and Bowmer, 1986]. |
3002984
|
|
|
virF from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767558
|
|
45478535
|
YP_pCD34 |
|
NP_995362.1 |
putative thermoregulatory protein VirF |
Virulence factor |
MUTATION: lcrF mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
ypkA from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767571
|
|
45478514
|
YP_pCD13 |
|
NP_995341.1 |
putative targeted effector protein kinase YpkA |
Virulence factor |
MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice [Ref6511:Galyov et al., 1993]. |
8441468
|
|
|
yopM from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767574
|
|
45478559
|
YP_pCD60 |
|
NP_995386.1 |
putative targeted effector protein YopM |
Virulence factor |
MUTATION: yopM mutant is attenuated in mice compared to the wild type [Ref6505:Leung et al., 1990]. |
2401564
|
|
|
yscH from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767576
|
|
45478527
|
YP_pCD26 |
|
NP_995354.1 |
putative type III secretion protein YscH |
Virulence factor |
MUTATION: The LD50 for the mouse of the yscH mutant was 10-fold higher than that of the parental strain indicating that YopR is involved in pathogenesis [Ref6610:Allaoui et al., 1995]. |
8709853
|
|
|
yopE from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767578
|
|
45478574
|
YP_pCD81 |
|
NP_995401.1 |
putative outer membrane virulence protein YopE |
Virulence factor |
MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice [Ref6502:Rosqvist et al., 1990]. |
2191183
|
|
|
ypkA from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149271
|
|
31795457
|
Y0009 |
|
NP_857907.1 |
secreted protein kinase |
Virulence factor |
MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice [Ref6511:Galyov et al., 1993]. |
8441468
|
|
|
yopH from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149274
|
|
31795460
|
Y0013 |
|
NP_857910.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis [Ref6510:Andersson et al., 1996]. |
8809758
|
|
|
yscH |
Yersinia pestis |
1149284
|
|
31795520
|
Y0024 |
|
NP_857920.1 |
secreted protein |
Virulence factor |
MUTATION: The LD50 for the mouse of the yscH mutant was 10-fold higher than that of the parental strain indicating that YopR is involved in pathogenesis [Ref6610:Allaoui et al., 1995]. |
8709853
|
|
|
lcrF from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149292
|
|
31795474
|
Y0032 |
|
NP_857928.1 |
transcriptional regulator |
Virulence factor |
MUTATION: lcrF mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
lcrV from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149310
|
|
31795491
|
Y0050 |
|
NP_857946.1 |
secreted effector protein |
Virulence factor |
MUTATION: lcrV mutants are avirulent in mice [Ref6509:Skrzypek and Straley, 1995]. |
7730287
|
|
|
lcrH from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149311
|
|
31795492
|
Y0051 |
|
NP_857947.1 |
secretion chaperone |
Virulence factor |
MUTATION: lcrH mutant is avirulent in mice [Ref6508:Price and Straley, 1989]. |
2707857
|
|
|
yopB from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149312
|
|
31795493
|
Y0052 |
|
NP_857948.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells [Ref6507:HÃ¥kansson et al., 1996]. |
8918459
|
|
|
yopD from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149313
|
|
31795494
|
Y0053 |
|
NP_857949.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells [Ref6506:Rosqvist et al., 1991]. |
1937815
|
|
|
yopM from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149317
|
|
31795498
|
Y0059 |
|
NP_857953.1 |
Yop targeted effector protein |
Virulence factor |
MUTATION: yopM mutant is attenuated in mice compared to the wild type [Ref6505:Leung et al., 1990]. |
2401564
|
|
|
yopT from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149322
|
|
31795525
|
Y0065 |
|
NP_857958.1 |
Yop targeted effector |
Virulence factor |
TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT [Ref6504:Iriarte and Cornelis, 1998]. |
9723929
|
|
|
yopK from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149323
|
|
31795502
|
Y0066 |
|
NP_857959.1 |
Yop targeting protein |
Virulence factor |
MUTATION: yopK mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days [Ref6503:Straley and Bowmer, 1986]. |
3002984
|
|
|
yopE from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149332
|
|
31795510
|
Y0077 |
|
NP_857967.1 |
secreted effector |
Virulence factor |
MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice [Ref6502:Rosqvist et al., 1990]. |
2191183
|
|
|
pla from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149148
|
|
31795332
|
YPKp07 |
|
NP_857784.1 |
outer membrane protease |
Virulence factor |
MUTATION: pla mutant is attenuated in mice [Ref6501:Sodeinde et al., 1992]. |
1439793
|
|
|
yscH from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149097
|
|
31795264
|
YKCD1p10 |
|
NP_857725.1 |
secreted effector protein |
Virulence factor |
MUTATION: The LD50 for the mouse of the yscH mutant was 10-fold higher than that of the parental strain indicating that YopR is involved in pathogenesis [Ref6610:Allaoui et al., 1995]. |
8709853
|
|
|
lcrF from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149104
|
|
31795271
|
YKCD1p18 |
|
NP_857733.1 |
transcriptional regulator |
Virulence factor |
MUTATION: lcrF mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
lcrV from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149118
|
|
31795291
|
YKCD1p35 |
|
NP_857751.1 |
secreted effector protein |
Virulence factor |
MUTATION: lcrV mutants are avirulent in mice [Ref6509:Skrzypek and Straley, 1995]. |
7730287
|
|
|
lcrH from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149119
|
|
31795292
|
YKCD1p36 |
|
NP_857752.1 |
secretion chaperone |
Virulence factor |
MUTATION: lcrH mutant is avirulent in mice [Ref6508:Price and Straley, 1989]. |
2707857
|
|
|
yopB from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149120
|
|
31795293
|
YKCD1p37 |
|
NP_857753.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells [Ref6507:HÃ¥kansson et al., 1996]. |
8918459
|
|
|
yopD from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149121
|
|
31795294
|
YKCD1p38 |
|
NP_857754.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells [Ref6506:Rosqvist et al., 1991]. |
1937815
|
|
|
yopM from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149123
|
|
31795297
|
YKCD1p41 |
|
NP_857756.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopM mutant is attenuated in mice compared to the wild type [Ref6505:Leung et al., 1990]. |
2401564
|
|
|
yopK from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149124
|
|
31795300
|
YKCD1p49 |
|
NP_857759.1 |
targeting protein |
Virulence factor |
MUTATION: yopK mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days [Ref6503:Straley and Bowmer, 1986]. |
3002984
|
|
|
yopE from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149129
|
|
31795304
|
YKCD1p59 |
|
NP_857762.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice [Ref6502:Rosqvist et al., 1990]. |
2191183
|
|
|
ypkA from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149139
|
|
31795319
|
YKCD1p81 |
|
NP_857776.1 |
similar to Yersinia pseudotuberculosis protein kinase A |
Virulence factor |
MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice [Ref6511:Galyov et al., 1993]. |
8441468
|
|
|
yopH from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149142
|
|
31795323
|
YKCD1p83 |
|
NP_857779.1 |
secreted effector protein |
Virulence factor |
MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis [Ref6510:Andersson et al., 1996]. |
8809758
|
|
|
yopT from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
2700511
|
|
31795299
|
YKCD1p48 |
|
NP_857758.1 |
secreted effector protein |
Virulence factor |
TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT [Ref6504:Iriarte and Cornelis, 1998]. |
9723929
|
|
|
caf1A from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149093
|
|
31795235
|
YPKMT066 |
|
NP_857693.1 |
F1 capsule protein |
Virulence factor |
MUTATION: caf1A mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
caf1M from Yersinia pestis KIM 10 |
Yersinia pestis KIM 10 |
1149094
|
|
31795236
|
YPKMT067 |
|
NP_857694.1 |
F1 capsule protein |
Virulence factor |
MUTATION: caf1M mutants are attenuated in mice [Ref6402:Welkos et al., 2004]. |
14711524
|
|
|
ugd |
Yersinia pestis biovar Microtus str. 91001 |
2763750
|
|
45441774
|
YP_1973 |
|
NP_993313.1 |
putative nucleotide sugar dehydrogenase |
Virulence factor |
MUTATION: ugd mutant had defects in intracellular survival in macrophages [Ref6391:Grabenstein et al., 2006]. |
16790745
|
|
|
pcm from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2763931
|
|
45440187
|
YP_0330 |
|
NP_991726.1 |
protein-L-isoaspartate O-methyltransferase |
Virulence factor |
MUTATION: pcm mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
hfq from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2764073
|
|
45440383
|
YP_0529 |
|
NP_991922.1 |
RNA-binding protein Hfq |
Virulence factor |
MUTATION: hfq mutant is highly attenuated in mice after subcutaneous or intravenous injection and has attenuated survival in macrophages [Ref6386:Geng et al., 2009]. |
19593436
|
|
|
greA from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2764186
|
|
45440432
|
YP_0578 |
|
NP_991971.1 |
transcription elongation factor GreA |
Virulence factor |
MUTATION: greA mutants are attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
ompX from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2764362
|
|
45442111
|
YP_2321 |
|
NP_993650.1 |
outer membrane protein X |
Virulence factor |
MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells [Ref6389:Kolodziejek et al., 2007]. |
17768237
|
|
|
ssrA from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2764482
|
|
0
|
YP_s4 |
|
- |
miscRNA |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
smpB from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2764498
|
|
45440889
|
YP_1055 |
|
NP_992428.1 |
SsrA-binding protein |
Virulence factor |
MUTATION: smpB ssrA mutant is attenuated in mice [Ref6398:Okan et al., 2010]. |
20065026
|
|
|
yfeA from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2764801
|
|
45442017
|
YP_2227 |
|
NP_993556.1 |
periplasmic-binding protein |
Virulence factor |
MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously [Ref6392:Bearden and Perry, 1999]. |
10231495
|
|
|
yfeB from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2764839
|
|
45442018
|
YP_2228 |
|
NP_993557.1 |
ATP-binding transport protein |
Virulence factor |
MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously [Ref6392:Bearden and Perry, 1999]. |
10231495
|
|
|
ybtP from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2764925
|
|
45441470
|
YP_1656 |
|
NP_993009.1 |
permease and ATP-binding protein of yersiniabactin-iron ABC transporter |
Virulence factor |
MUTATION: ybtP mutant is avirulent in mouse bubonic plague model [Ref6394:Fetherston et al., 1999]. |
10231486
|
|
|
irp2 from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2764958
|
|
45441468
|
YP_1654 |
|
NP_993007.1 |
yersiniabactin biosynthetic protein |
Virulence factor |
MUTATION: irp2 mutants are unable to grow at 37 degrees in iron deficient media [Ref6395:Fetherston et al., 1995]. |
7896707
|
|
|
fyuA from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2764984
|
|
45441463
|
YP_1649 |
|
NP_993002.1 |
pesticin/yersiniabactin receptor protein |
Virulence factor |
MUTATION: psn (fyuA) mutant is unable to grow on iron-deficient media at 37 degrees C [Ref6395:Fetherston et al., 1995]. |
7896707
|
|
|
yapE from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2765067
|
|
45443096
|
YP_3347 |
|
NP_994635.1 |
putative autotransporter protein |
Virulence factor |
MUTATION: yapE mutant is attenuated in mice and has impaired colonization in bubonic plague model [Ref6399:Lawrenz et al., 2009]. |
18936182
|
|
|
pgm from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2765450
|
|
45442271
|
YP_2488 |
|
NP_993810.1 |
phosphoglucomutase |
Virulence factor |
MUTATION: pgm mutant of Y. pestis is attenuated in mice [Ref6388:Welkos et al., 2002]. |
12009274
|
|
|
lpp from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2765473
|
|
45441973
|
YP_2181 |
|
NP_993512.1 |
major outer membrane lipoprotein |
Virulence factor |
MUTATION: lpp deletion mutant is attenuated in mice [Ref6514:Liu et al., 2010]. |
19737605
|
|
|
purK from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2765634
|
|
45440690
|
YP_0847 |
|
NP_992229.1 |
phosphoribosylaminoimidazole carboxylase ATPase subunit |
Virulence factor |
MUTATION: purK mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
purH from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2765673
|
|
45442845
|
YP_3091 |
|
NP_994384.1 |
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase |
Virulence factor |
MUTATION: purH mutant is attenuated in mice [Ref6385:Flashner et al., 2004]. |
14742535
|
|
|
phoP from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2765857
|
|
45441575
|
YP_1764 |
|
NP_993114.1 |
DNA-binding response regulator in two-component regulatory system with PhoQ |
Virulence factor |
MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain [Ref6390:Oyston et al., 2000]. |
10816493
|
|
|
msbB from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2766044
|
|
45441708
|
YP_1906 |
|
NP_993247.1 |
lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase |
Virulence factor |
MUTATION: lpxM (msbB) mutant is attenuated in mice and guinea pigs [Ref6393:Feodorova et al., 2007]. |
17913308
|
|
|
psaA from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2766170
|
|
45441116
|
YP_1289 |
|
NP_992655.1 |
pH 6 Antigen fimbrial subunit |
Virulence factor |
MUTATION: psaA mutants have a 100-fold reduced 50% lethal dose in mice [Ref6397:Lindler et al., 1990]. |
2164509
|
|
|
spoT from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2766260
|
|
45439904
|
YP_0039 |
|
NP_991443.1 |
bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
mgtC from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2766450
|
|
45441600
|
YP_1790 |
|
NP_993139.1 |
Mg(2+) transport ATPase protein C |
Virulence factor |
MUTATION: mgtC mutants are defective in early intracellular survival in macrophages compared to wild type Y. pestis [Ref6391:Grabenstein et al., 2006]. |
16790745
|
|
|
dam from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2766547
|
|
45440018
|
YP_0156 |
|
NP_991557.1 |
DNA adenine methylase |
Virulence factor |
MUTATION: dam mutant is attenuated in mice [Ref6400:Robinson et al., 2005]. |
16188402
|
|
|
psaE from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2766548
|
|
45441118
|
YP_1291 |
|
NP_992657.1 |
putative regulatory protein |
Virulence factor |
MUTATION: psaE mutants are attenuated in mice [Ref6397:Lindler et al., 1990]. |
2164509
|
|
|
relA from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2766682
|
|
45440165
|
YP_0306 |
|
NP_991704.1 |
GDP/GTP pyrophosphokinase |
Virulence factor |
MUTATION: relA spoT deletion mutants are attenuated in mice [Ref6384:Sun et al., 2009]. |
19701461
|
|
|
crp from Yersinia pestis biovar Microtus str. 91001 |
Yersinia pestis biovar Microtus str. 91001 |
2767357
|
|
45440035
|
YP_0174 |
|
NP_991574.1 |
cAMP-regulatory protein |
Virulence factor |
MUTATION: crp mutant is attenuated in mice [Ref6401:Sun et al., 2010]. |
20086087
|
