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yapE from Yersinia pestis KIM 10

Victor ID 794
Gene Name yapE from Yersinia pestis KIM 10
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
NCBI Gene ID 1148792
NCBI Protein GI 22127716
Locus Tag y3845
Protein Accession NP_671139.1
Other Database IDs UniProtKB-ID: Q8CZL1_YERPE
UniRef100: UniRef100_A4TQZ3
UniRef90: UniRef90_A4TQZ3
UniRef50: UniRef50_A4TQZ3
UniParc: UPI00000E4603
EMBL: AE009952
EMBL: AE017042
EMBL-CDS: AAM87390.1
EMBL-CDS: AAS63512.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
KEGG: ypk:y3845
KEGG: ypm:YP_3347
HOGENOM: HBG756940
ProtClustDB: CLSK889609
BioCyc: YPES187410:Y3845-MONOMER
Taxonomy ID 187410
Gene Starting Position 4280306
Gene Ending Position 4283560
Gene Strand (Orientation) +
Protein Name autotransporter protein
DNA Sequence 
>gi|22123922:4280306-4283560 Yersinia pestis KIM 10 chromosome, complete genome
TGTGTGTTGCTTTAATTATTCCAATAAAAACCCAAGGATGGTTATGAAAACAAACCGCTCTACGCTTTCC
CCGTGCTTTCGTAAAACAATGATAGCCAGTTTGTTGGTGCCTCTTTGCAGCCCCCTGTATAGCTGGGCGG
TACAAACGGCCAGCATAACAGATGGCAGCACGATGGTTATCTCTGGGGGTTATGACACTGAGGCTAATAA
CCACTCGGCGGTATTTGTGCAAGGTTCCGGTAGCACCATTAATGGTGGCTCCGATGTCGTTATTGAAACC
ACGGGGGTTGGTGCAATTGGTGCCTATGCCTCTGAAGGTGGGTCGTTGGGGCTGACGGGTTCGACTATCA
ATACCGAGAATGGTGTGGCTTTTGGTGTCTTAAATGACAAAGGTACGGTGAATTTACAAGGTGGTACGAT
TACCACGAAAGGTCAGACGGCATATGGCGTGTATTCCTCTGGTTTGGGCAGTAATACCGATATTCACAGT
TCGGCGATCACGACCAGCTACTCGTTAACCCACGCTATTTATGGTGCCGGAGGGACGGGATTGACATTGA
ACAATACCACCCTCAATACCAGTGGCAGTGGTAGCTATGGCATTTATCTGGATGGTTCCGGAGGGAGCTT
AACGGGCGCGAATAACACCATTAATAGTACTCATGCGACCAAGGGTGCGGGTATCTATATTTCAGCGGGT
GGCTCAAATGCGACTTTAGATAACACCACACTGAATATCACTAAAGGTGCTGTTGGTGTGAATGTGGGGG
AGGGTTCATCTATTACGATGGATGGCCTTATTGCCACCGGTAATATCACCAACCTATTTAAAGTGAATGG
GAATGCCTCGGTCAGTAATGCCAATATCGAATTAGCCGCGGGTGGCGTATTAATGGCACAGGGCAGCAGT
GCGTCCAATCAAGCGGTCATCATATTAAATAATGTCAATGTTATTTCTAACAGCGGCAGCACGACACTGG
TTGATGTTAATAAGGACGCTGACGTCACCATTAATGGGGGGGCTTACCACTCAAAAGGTAACAATGCGAA
GGGAATCTGGGTTCGAGATAATAACTCATCGCTGAATGTCGATAACGCCGTGATTATCACCGAGGGCGTG
AATGCAACGGCGATTGAAAATCGTGGCACCGCTATCGTAAAAAATACCACGGTGATAACTAAAGGGAATA
ACTCTCACGGCCTCTACTCTGAGCAAAGCCTTGATGCCACCAATATGGCAATTTCCACTGCGGGGATTGG
CAGTATTGGGGTGGCGGCAGCTAAAGGCGGTAACCTAAATCTGAATGATGCATTCATCGAGACGACGGGT
AATTCAGGTATGGTGCTGGGTACTTTTGCCGACTCATCCATCAGCGCTAAAAATATTACAGGGATCTCGA
CCGGCGCTGGTGCTTATGCCTTGTGGGTAGATGATGGTAGCTCAATTCTGCTGGAAGAGAGCCAAATTAC
CACTCAAGGCCAGGGCGCGGGAGGGATTTATGCCTCAAATACCGGGACCGGCTCTCACACCGCTTACACT
CAGGTTACGCTGAACAACTCACAGATTCATAGTGAGCAGGGGCCGGGTATCTGGGCTAATGGTGCTGACA
TTAATGTTGATGTGAAGAATGGTTCGCAGTTAACGGGAGGCAATGGGTTATTGGTCTATGCCTCAAGTAA
TGCAGGGGCCGCCAGCAATGTCAATGTGAATGGCGATAACCACGCCGTTCTGTTGGGTGATATTCACGCC
GCAGAAAACAGCAATATTAACCTGGCACTGAATAATAATTCCGTTTGGACGGGGGCGGCGACTAACGCCA
AACAGGTTGATATCGACAGCAGCAGTATCTGGAATTTAACGGGTGATGCAGATGTTGAGTCAATGCATGT
ATTGGGCCAGATGAACTTTATCTCAAATAGCAGTGACACTAATTCACGGGCTCCCTACGATAATTTCAGC
ACCTTAACGATCAACAGTAATGTCACCGGGAGTGGCAGTTTTACCTTTAATGTGCAATTGGGTGATAACG
ACTCACCAGTGGATAGACTCTATGTGATTGGTAATGCTTCTGGTGACCATGGGGTTCAGGTTATTAACCA
AGGCGGTTTGGGGGCATTGACCACGGGCGACGGGATTAACCTGATTACCGTTGATGGGGAGACCCATTCC
GGCTCATTTACTATGAGTAACTCGGTGAGCGCAGGGGCCTATGAATATTTCTTGTATAAGATAGATGACT
ACCGTTGGAACCTGCAATCTAATCTCATCAATCCCGGTCCTGGTCCTGAACCAGAAATTGAACCAGAAGA
GATAGCTTACCGCCCTGAAGTTCCTGGCTATATTGCCGCACCTTGGTTAAATGCATTTTATGGTTTTACT
ACTTTGGGTAGCTTGCACGAACGCCGTGGCTCGGCCGAGGGAGCAGCCGAAGGGTTTAATCAAGACTCAT
GGGGCCGGATCCGTGGGCAGCATAATAATTTTGACGCGGGCCGTTTTAGCTACGATTCAAATATCTGGTT
TATGCAATTGGGTCATGATGTCTATCAGGCCAAAAATGCCGCAGGCACTCAAGTGACTGGCGGTATGATG
ATCACCCTAGGTAAGCAGAATAGCGATACACGGGATCGGGCGCGGGCGATAAATCCGGATTTGTCGATCG
ATACCGGCAAGATCAAAACCGAGGCTTATGGGTTTGGGGGCTATTACACCCTGATGACCGAGGAAGGCGG
TTACCTTGATATCGTTAGCCAGGCGACGCTATACCGCAACAACTATGAGAGCCAACATAATACCAAGCAT
AATGGCTACGGTGTTGTGATGTCTGCCGAAGTGGGTCAGCCGTATCCACTGGCTGCTGGCTGGGTAGTGG
AGCCTCAGGGGCAGCTAAAATATCAATACCTGCACCTGAGTCCGAAGAATTTCAACGATAGCATTTCAGA
GATCGGGGGGACGGATTACTCTGTTGGTCAGGTACGTGGCGGGCTGCGTCTGTTCAGTGACGCGAGTGAG
AAGCGGGACATTAAGCCTTATTTGACCACCGATGTGCTTCACCAGTTAGGCCGAAACCCACAGGTGACGG
TAGCGACGGTGGATATCCGTCCTGACTTCACAAAAACCTTCTGGCAGGGGGGCGCAGGGGTGACCGCCAA
AGTGAATAGTCAGGTTGATCTCTATGCTGATGCGAAATACCAAAAATCCTTTGATGGCAAATTAGATGGC
TACTTAGGTAATTTGGGCGTGAAAGTCAGTTTCTG
Protein Sequence 
>gi|22127716|ref|NP_671139.1| autotransporter protein [Yersinia pestis KIM10+] MCCFNYSNKNPRMVMKTNRSTLSPCFRKTMIASLLVPLCSPLYSWAVQTASITDGSTMVISGGYDTEANNHSAVFVQGSGSTINGGSDVVIETTGVGAIGAYASEGGSLGLTGSTINTENGVAFGVLNDKGTVNLQGGTITTKGQTAYGVYSSGLGSNTDIHSSAITTSYSLTHAIYGAGGTGLTLNNTTLNTSGSGSYGIYLDGSGGSLTGANNTINSTHATKGAGIYISAGGSNATLDNTTLNITKGAVGVNVGEGSSITMDGLIATGNITNLFKVNGNASVSNANIELAAGGVLMAQGSSASNQAVIILNNVNVISNSGSTTLVDVNKDADVTINGGAYHSKGNNAKGIWVRDNNSSLNVDNAVIITEGVNATAIENRGTAIVKNTTVITKGNNSHGLYSEQSLDATNMAISTAGIGSIGVAAAKGGNLNLNDAFIETTGNSGMVLGTFADSSISAKNITGISTGAGAYALWVDDGSSILLEESQITTQGQGAGGIYASNTGTGSHTAYTQVTLNNSQIHSEQGPGIWANGADINVDVKNGSQLTGGNGLLVYASSNAGAASNVNVNGDNHAVLLGDIHAAENSNINLALNNNSVWTGAATNAKQVDIDSSSIWNLTGDADVESMHVLGQMNFISNSSDTNSRAPYDNFSTLTINSNVTGSGSFTFNVQLGDNDSPVDRLYVIGNASGDHGVQVINQGGLGALTTGDGINLITVDGETHSGSFTMSNSVSAGAYEYFLYKIDDYRWNLQSNLINPGPGPEPEIEPEEIAYRPEVPGYIAAPWLNAFYGFTTLGSLHERRGSAEGAAEGFNQDSWGRIRGQHNNFDAGRFSYDSNIWFMQLGHDVYQAKNAAGTQVTGGMMITLGKQNSDTRDRARAINPDLSIDTGKIKTEAYGFGGYYTLMTEEGGYLDIVSQATLYRNNYESQHNTKHNGYGVVMSAEVGQPYPLAAGWVVEPQGQLKYQYLHLSPKNFNDSISEIGGTDYSVGQVRGGLRLFSDASEKRDIKPYLTTDVLHQLGRNPQVTVATVDIRPDFTKTFWQGGAGVTAKVNSQVDLYADAKYQKSFDGKLDGYLGNLGVKVSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yapE mutant is attenuated in mice and has impaired colonization in bubonic plague model (Lawrenz et al., 2009).
COG COG3468MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Lawrenz et al., 2009: Lawrenz MB, Lenz JD, Miller VL. A novel autotransporter adhesin is required for efficient colonization during bubonic plague. Infection and immunity. 2009; 77(1); 317-326. [PubMed: 18936182].