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y1436

Victor ID 770
Gene Name y1436
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
NCBI Gene ID 1146382
NCBI Protein GI 22125333
Locus Tag y1436
Genbank Accession AE009952
Protein Accession NP_668756
Other Database IDs UniProtKB-ID: Q8D0X8_YERPE
UniRef100: UniRef100_A4TML6
UniRef90: UniRef90_A4TML6
UniRef50: UniRef50_P76134
UniParc: UPI00000E4430
EMBL: AE009952
EMBL-CDS: AAM85007.1
RefSeq_NT: NC_004088.1
GenomeReviews: AE009952_GR
KEGG: ypk:y1436
HOGENOM: HBG484795
ProtClustDB: CLSK880036
BioCyc: YPES187410:Y1436-MONOMER
Taxonomy ID 187410
Gene Starting Position 1591463
Gene Ending Position 1592650
Gene Strand (Orientation) +
Protein Name enzyme
Protein pI 7.03
Protein Weight 43511.37
Protein Length 395
Protein Note residues 5 to 386 of 395 are 65.79 pct identical to residues 6 to 388 of 390 from E. coli K12 : B1497; residues 5 to 386 of 395 are 66.05 pct identical to residues 6 to 388 of 390 from GenPept : >gb|AAG56271.1|AE005355_5 (AE005355) putative enzyme [Escherichia coli O157:H7 EDL933]
DNA Sequence 
>gi|22123922:1591463-1592650 Yersinia pestis KIM 10 chromosome, complete genome
CATGAGGAAAACTATGCATATCACGGCTAAACCAACCAGCTACCAGTGTAATTTAAAGTGTGATTACTGC
TTTTATCTCAGTAAAGAAAACATTTTTCAGCACAAAGGTTGGATGACTGAAGAAACCCTTGAAACATTTA
TCGAGCGATATATCAGTGCATCGGGGCATGATGTGTATTTCACTTGGCAAGGGGGTGAGCCTACCATGGC
TGGGCTGGATTTCTTTGAGAAAGCGATACAGTATCAGAACCGCTATAAAGGGACTAAAAAAATACACAAC
GCTTTACAAACTAACGGTATTTTATTAGATGATGCATGGTGTCTCTTTCTAAGAGAAAATCATTTTTTAG
TCGGTGTGTCTATTGATGGCCCTAAAGAGTTACACGATCGCTACCGTGTGACTCGCTCAGGCAAAGGATC
GTTTGATAAAGTGATGGCAGGTATTGAGCAACTCAAAAAACATCAGGTAGAGTTTAATACATTAACCGTG
ATAAATCGTATCAATGTAAAATACCCCCTTGAAGTTTATCGAACGTTAAAATCTATCGGTGCTAAACATA
TCCAATTTATTGAACTGTTGGAAACAACCGAGCCTAATATTGATTTTTCAAATCAAAAAAGCACGTTTGA
ACTTATTGAGTTCACTGTCCCTGCGGTTGATTATGGCCATTTCATGGCGGAGGTCTTCAAAGAATGGGTT
CGCCATGATGTAGGAACTCTCTTTATTCGCCAGTTTGAGTCTTTTGTCAGCCGATTTATTGGCAATGGGC
ACACGAGCTGTGTTTTCCAAAAATCGTGCAAAAATAATTTTGTGATGGAGTCCAATGGTGACATTTATGA
ATGTGATCACTTTGTCTACCCTGAGTATAAAATAGGCAATATTTACCACGATAAATTGGATTCGTTGGCG
AGCGATAAATTATCCGCGCAAAAAGAGGTGCTATCTGAGTCATGCCGTAAGTGTATGTATAAAGCCATTT
GCTATGGCGGTTGCCCAAAACATAGGATTGATCAGGACAGCGATGGGATGAAATCCTATTTTTGCGCAGG
GTATAAAATACTCTTCTCGGTTATGGTGCCTTATATGAATGCGCTGGCTGAATTAGAAAAAAATGGTATT
CCATTGGATAAGATCATGGGTATCGTCGATGACATTGAATGTGGAATAAAATCACAACAGCAGCATTA
Protein Sequence 
>gi|22125333|ref|NP_668756.1| enzyme [Yersinia pestis KIM 10]
MRKTMHITAKPTSYQCNLKCDYCFYLSKENIFQHKGWMTEETLETFIERYISASGHDVYFTWQGGEPTMA
GLDFFEKAIQYQNRYKGTKKIHNALQTNGILLDDAWCLFLRENHFLVGVSIDGPKELHDRYRVTRSGKGS
FDKVMAGIEQLKKHQVEFNTLTVINRINVKYPLEVYRTLKSIGAKHIQFIELLETTEPNIDFSNQKSTFE
LIEFTVPAVDYGHFMAEVFKEWVRHDVGTLFIRQFESFVSRFIGNGHTSCVFQKSCKNNFVMESNGDIYE
CDHFVYPEYKIGNIYHDKLDSLASDKLSAQKEVLSESCRKCMYKAICYGGCPKHRIDQDSDGMKSYFCAG
YKILFSVMVPYMNALAELEKNGIPLDKIMGIVDDIECGIKSQQQH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: y1436 mutant is attenuated in mice (Flashner et al., 2004).
COG COG0641R, under R: General function prediction only
References
Flashner et al., 2004: Flashner Y, Mamroud E, Tidhar A, Ber R, Aftalion M, Gur D, Lazar S, Zvi A, Bino T, Ariel N, Velan B, Shafferman A, Cohen S. Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates. Infection and immunity. 2004; 72(2); 908-915. [PubMed: 14742535].