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yapE from Yersinia pestis biovar Microtus str. 91001

Victor ID 2548
Gene Name yapE from Yersinia pestis biovar Microtus str. 91001
Sequence Strain (Species/Organism) Yersinia pestis biovar Microtus str. 91001
NCBI Gene ID 2765067
NCBI Protein GI 45443096
Locus Tag YP_3347
Protein Accession NP_994635.1
Other Database IDs UniProtKB-ID: Q8CZL1_YERPE
UniRef100: UniRef100_A4TQZ3
UniRef90: UniRef90_A4TQZ3
UniRef50: UniRef50_A4TQZ3
UniParc: UPI00000E4603
EMBL: AE009952
EMBL: AE017042
EMBL-CDS: AAM87390.1
EMBL-CDS: AAS63512.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
KEGG: ypk:y3845
KEGG: ypm:YP_3347
HOGENOM: HBG756940
ProtClustDB: CLSK889609
BioCyc: YPES187410:Y3845-MONOMER
Taxonomy ID 229193
Gene Starting Position 3744349
Gene Ending Position 3747603
Gene Strand (Orientation) -
Protein Name putative autotransporter protein
DNA Sequence 
>gi|45439865:3744349-3747603 Yersinia pestis biovar Microtus str. 91001 chromosome, complete genome
ATCAGAAACTGACTTTCACGCCCAAATTACCTAAGTAGCCATCTAATTTGCCATCAAAGGATTTTTGGTA
TTTCGCATCAGCATAGAGATCAACCTGACTATTCACTTTGGCGGTCACCCCTGCGCCCCCCTGCCAGAAG
GTTTTTGTGAAGTCAGGACGGATATCCACCGTCGCTACCGTCACCTGTGGGTTTCGGCCTAACTGGTGAA
GCACATCGGTGGTCAAATAAGGCTTAATGTCCCGCTTCTCACTCGCGTCACTGAACAGACGCAGCCCGCC
ACGTACCTGACCAACAGAGTAATCCGTCCCCCCGATCTCTGAAATGCTATCGTTGAAATTCTTCGGACTC
AGGTGCAGGTATTGATATTTTAGCTGCCCCTGAGGCTCCACTACCCAGCCAGCAGCCAGTGGATACGGCT
GACCCACTTCGGCAGACATCACAACACCGTAGCCATTATGCTTGGTATTATGTTGGCTCTCATAGTTGTT
GCGGTATAGCGTCGCCTGGCTAACGATATCAAGGTAACCGCCTTCCTCGGTCATCAGGGTGTAATAGCCC
CCAAACCCATAAGCCTCGGTTTTGATCTTGCCGGTATCGATCGACAAATCCGGATTTATCGCCCGCGCCC
GATCCCGTGTATCGCTATTCTGCTTACCTAGGGTGATCATCATACCGCCAGTCACTTGAGTGCCTGCGGC
ATTTTTGGCCTGATAGACATCATGACCCAATTGCATAAACCAGATATTTGAATCGTAGCTAAAACGGCCC
GCGTCAAAATTATTATGCTGCCCACGGATCCGGCCCCATGAGTCTTGATTAAACCCTTCGGCTGCTCCCT
CGGCCGAGCCACGGCGTTCGTGCAAGCTACCCAAAGTAGTAAAACCATAAAATGCATTTAACCAAGGTGC
GGCAATATAGCCAGGAACTTCAGGGCGGTAAGCTATCTCTTCTGGTTCAATTTCTGGTTCAGGACCAGGA
CCGGGATTGATGAGATTAGATTGCAGGTTCCAACGGTAGTCATCTATCTTATACAAGAAATATTCATAGG
CCCCTGCGCTCACCGAGTTACTCATAGTAAATGAGCCGGAATGGGTCTCCCCATCAACGGTAATCAGGTT
AATCCCGTCGCCCGTGGTCAATGCCCCCAAACCGCCTTGGTTAATAACCTGAACCCCATGGTCACCAGAA
GCATTACCAATCACATAGAGTCTATCCACTGGTGAGTCGTTATCACCCAATTGCACATTAAAGGTAAAAC
TGCCACTCCCGGTGACATTACTGTTGATCGTTAAGGTGCTGAAATTATCGTAGGGAGCCCGTGAATTAGT
GTCACTGCTATTTGAGATAAAGTTCATCTGGCCCAATACATGCATTGACTCAACATCTGCATCACCCGTT
AAATTCCAGATACTGCTGCTGTCGATATCAACCTGTTTGGCGTTAGTCGCCGCCCCCGTCCAAACGGAAT
TATTATTCAGTGCCAGGTTAATATTGCTGTTTTCTGCGGCGTGAATATCACCCAACAGAACGGCGTGGTT
ATCGCCATTCACATTGACATTGCTGGCGGCCCCTGCATTACTTGAGGCATAGACCAATAACCCATTGCCT
CCCGTTAACTGCGAACCATTCTTCACATCAACATTAATGTCAGCACCATTAGCCCAGATACCCGGCCCCT
GCTCACTATGAATCTGTGAGTTGTTCAGCGTAACCTGAGTGTAAGCGGTGTGAGAGCCGGTCCCGGTATT
TGAGGCATAAATCCCTCCCGCGCCCTGGCCTTGAGTGGTAATTTGGCTCTCTTCCAGCAGAATTGAGCTA
CCATCATCTACCCACAAGGCATAAGCACCAGCGCCGGTCGAGATCCCTGTAATATTTTTAGCGCTGATGG
ATGAGTCGGCAAAAGTACCCAGCACCATACCTGAATTACCCGTCGTCTCGATGAATGCATCATTCAGATT
TAGGTTACCGCCTTTAGCTGCCGCCACCCCAATACTGCCAATCCCCGCAGTGGAAATTGCCATATTGGTG
GCATCAAGGCTTTGCTCAGAGTAGAGGCCGTGAGAGTTATTCCCTTTAGTTATCACCGTGGTATTTTTTA
CGATAGCGGTGCCACGATTTTCAATCGCCGTTGCATTCACGCCCTCGGTGATAATCACGGCGTTATCGAC
ATTCAGCGATGAGTTATTATCTCGAACCCAGATTCCCTTCGCATTGTTACCTTTTGAGTGGTAAGCCCCC
CCATTAATGGTGACGTCAGCGTCCTTATTAACATCAACCAGTGTCGTGCTGCCGCTGTTAGAAATAACAT
TGACATTATTTAATATGATGACCGCTTGATTGGACGCACTGCTGCCCTGTGCCATTAATACGCCACCCGC
GGCTAATTCGATATTGGCATTACTGACCGAGGCATTCCCATTCACTTTAAATAGGTTGGTGATATTACCG
GTGGCAATAAGGCCATCCATCGTAATAGATGAACCCTCCCCCACATTCACACCAACAGCACCTTTAGTGA
TATTCAGTGTGGTGTTATCTAAAGTCGCATTTGAGCCACCCGCTGAAATATAGATACCCGCACCCTTGGT
CGCATGAGTACTATTAATGGTGTTATTCGCGCCCGTTAAGCTCCCTCCGGAACCATCCAGATAAATGCCA
TAGCTACCACTGCCACTGGTATTGAGGGTGGTATTGTTCAATGTCAATCCCGTCCCTCCGGCACCATAAA
TAGCGTGGGTTAACGAGTAGCTGGTCGTGATCGCCGAACTGTGAATATCGGTATTACTGCCCAAACCAGA
GGAATACACGCCATATGCCGTCTGACCTTTCGTGGTAATCGTACCACCTTGTAAATTCACCGTACCTTTG
TCATTTAAGACACCAAAAGCCACACCATTCTCGGTATTGATAGTCGAACCCGTCAGCCCCAACGACCCAC
CTTCAGAGGCATAGGCACCAATTGCACCAACCCCCGTGGTTTCAATAACGACATCGGAGCCACCATTAAT
GGTGCTACCGGAACCTTGCACAAATACCGCCGAGTGGTTATTAGCCTCAGTGTCATAACCCCCAGAGATA
ACCATCGTGCTGCCATCTGTTATGCTGGCCGTTTGTACCGCCCAGCTATACAGGGGGCTGCAAAGAGGCA
CCAACAAACTGGCTATCATTGTTTTACGAAAGCACGGGGAAAGCGTAGAGCGGTTTGTTTTCATAACCAT
CCTTGGGTTTTTATTGGAATAATTAAAGCAACACA
Protein Sequence 
>gi|45443096|ref|NP_994635.1| autotransporter protein [Yersinia pestis biovar Microtus str. 91001] MCCFNYSNKNPRMVMKTNRSTLSPCFRKTMIASLLVPLCSPLYSWAVQTASITDGSTMVISGGYDTEANNHSAVFVQGSGSTINGGSDVVIETTGVGAIGAYASEGGSLGLTGSTINTENGVAFGVLNDKGTVNLQGGTITTKGQTAYGVYSSGLGSNTDIHSSAITTSYSLTHAIYGAGGTGLTLNNTTLNTSGSGSYGIYLDGSGGSLTGANNTINSTHATKGAGIYISAGGSNATLDNTTLNITKGAVGVNVGEGSSITMDGLIATGNITNLFKVNGNASVSNANIELAAGGVLMAQGSSASNQAVIILNNVNVISNSGSTTLVDVNKDADVTINGGAYHSKGNNAKGIWVRDNNSSLNVDNAVIITEGVNATAIENRGTAIVKNTTVITKGNNSHGLYSEQSLDATNMAISTAGIGSIGVAAAKGGNLNLNDAFIETTGNSGMVLGTFADSSISAKNITGISTGAGAYALWVDDGSSILLEESQITTQGQGAGGIYASNTGTGSHTAYTQVTLNNSQIHSEQGPGIWANGADINVDVKNGSQLTGGNGLLVYASSNAGAASNVNVNGDNHAVLLGDIHAAENSNINLALNNNSVWTGAATNAKQVDIDSSSIWNLTGDADVESMHVLGQMNFISNSSDTNSRAPYDNFSTLTINSNVTGSGSFTFNVQLGDNDSPVDRLYVIGNASGDHGVQVINQGGLGALTTGDGINLITVDGETHSGSFTMSNSVSAGAYEYFLYKIDDYRWNLQSNLINPGPGPEPEIEPEEIAYRPEVPGYIAAPWLNAFYGFTTLGSLHERRGSAEGAAEGFNQDSWGRIRGQHNNFDAGRFSYDSNIWFMQLGHDVYQAKNAAGTQVTGGMMITLGKQNSDTRDRARAINPDLSIDTGKIKTEAYGFGGYYTLMTEEGGYLDIVSQATLYRNNYESQHNTKHNGYGVVMSAEVGQPYPLAAGWVVEPQGQLKYQYLHLSPKNFNDSISEIGGTDYSVGQVRGGLRLFSDASEKRDIKPYLTTDVLHQLGRNPQVTVATVDIRPDFTKTFWQGGAGVTAKVNSQVDLYADAKYQKSFDGKLDGYLGNLGVKVSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yapE mutant is attenuated in mice and has impaired colonization in bubonic plague model (Lawrenz et al., 2009).
COG COG3468MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Lawrenz et al., 2009: Lawrenz MB, Lenz JD, Miller VL. A novel autotransporter adhesin is required for efficient colonization during bubonic plague. Infection and immunity. 2009; 77(1); 317-326. [PubMed: 18936182].