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yopH from Yersinia pestis CA88-4125

Victor ID 2488
Gene Name yopH from Yersinia pestis CA88-4125
Sequence Strain (Species/Organism) Yersinia pestis CA88-4125
NCBI Gene ID 5236107
NCBI Protein GI 149192673
Locus Tag YPE_4187
Protein Accession YP_001293905.1
Other Database IDs UniProtKB-ID: A6M3Q6_YERPE
UniRef100: UniRef100_P08538
UniRef90: UniRef90_P08538
UniRef50: UniRef50_P15273
UniParc: UPI00000D1266
EMBL: CP000722
EMBL-CDS: ABR14821.1
RefSeq_NT: NC_009595.1
OMA: SAHEIAN
ProtClustDB: CLSK862151
Taxonomy ID 412420
Plasmid No pCD1
Gene Starting Position 28425
Gene Ending Position 29831
Gene Strand (Orientation) +
Protein Name translocated protein-tyrosine kinase, inhibitor of phagocytosis
DNA Sequence 
>gi|149192647:28425-29831 Yersinia pestis CA88-4125 plasmid pCD1, complete sequence
CATGAACTTATCATTAAGCGATCTTCATCGTCAGGTATCTCGATTGGTGCAGCAAGAGAGCGGTGATTGT
ACCGGGAAATTAAGAGGTAACGTTGCTGCCAATAAAGAAACTACCTTTCAAGGTTTGACCATAGCCAGTG
GAGCCAGAGAGTCAGAAAAAGTATTTGCTCAAACTGTACTAAGCCACGTAGCAAATGTTGTTCTAACTCA
AGAAGATACCGCTAAGCTATTGCAAAGTACGGTAAAGCATAATTTGAATAATTATGACTTAAGAAGTGTC
GGCAATGGTAATAGTGTACTTGTCAGTTTACGTAGTGACCAAATGACACTACAAGACGCCAAAGTGCTGT
TGGAGGCCGCATTGCGACAAGAGTCGGGAGCGAGGGGGCATGTATCATCTCATTCACATTCAGCCCTTCA
CGCACCGGGAACCCCGGTGCGTGAAGGACTGCGTTCACATCTAGACCCCAGAACTCCACCGTTGCCACCG
CGTGAACGACCACACACTTCTGGCCATCACGGGGCTGGCGAAGCCAGAGCCACCGCACCAAGCACTGTTT
CTCCTTATGGCCCAGAAGCGCGCGCAGAACTCAGCAGCCGCCTCACCACATTGCGCAATACGCTGGCGCC
AGCAACGAATGATCCGCGTTACTTACAAGCCTGCGGCGGTGAAAAGCTAAACCGATTTAGAGATATTCAA
TGCTGTCGGCAAACCGCAGTACGCGCCGATCTTAATGCCAATTACATCCAGGTCGGTAACACTCGTACCA
TAGCGTGCCAGTATCCGCTACAATCTCAACTTGAAAGCCATTTCCGTATGCTGGCAGAAAACCGAACGCC
AGTGTTGGCTGTTTTAGCGTCCAGTTCTGAGATAGCCAATCAAAGATTCGGTATGCCAGATTATTTCCGC
CAGAGTGGTACCTATGGCAGTATCACTGTAGAGTCTAAAATGACTCAGCAAGTTGGTCTCGGTGACGGGA
TTATGGCAGATATGTATACTTTAACGATTCGTGAAGCGGGTCAAAAAACAATCTCTGTTCCTGTGGTTCA
TGTTGGCAATTGGCCCGATCAGACCGCAGTCAGCTCTGAAGTTACCAAGGCACTCGCTTCACTGGTAGAT
CAAACAGCAGAAACAAAACGCAATATGTATGAAAGCAAAGGAAGTTCAGCGGTAGGAGATGACTCCAAAT
TACGGCCGGTAATACATTGCCGTGCGGGTGTTGGCCGTACTGCGCAACTGATTGGCGCAATGTGCATGAA
TGATAGTCGTAATAGTCAGTTAAGCGTAGAAGATATGGTCAGCCAAATGCGAGTACAAAGAAATGGTATT
ATGGTACAAAAAGATGAGCAACTTGATGTTCTGATTAAGTTGGCTGAAGGACAAGGGCGACCATTATTAA
ATAGCTA
Protein Sequence 
>gi|149192673|ref|YP_001293905.1| translocated protein-tyrosine kinase, inhibitor of phagocytosis [Yersinia pestis CA88-4125] MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANVVLTQEDTAKLLQSTVKHNLNNYDLRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSALHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVGDDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis (Andersson et al., 1996).
References
Andersson et al., 1996: Andersson K, Carballeira N, Magnusson KE, Persson C, Stendahl O, Wolf-Watz H, Fällman M. YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis. Molecular microbiology. 1996; 20(5); 1057-1069. [PubMed: 8809758].