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yopD from Yersinia pestis CO92

Victor ID 1122
Gene Name yopD from Yersinia pestis CO92
Sequence Strain (Species/Organism) Yersinia pestis CO92
NCBI Gene ID 1172673
NCBI Protein GI 16082716
Locus Tag YPCD1.28c
Protein Accession NP_395162.1
Other Database IDs UniProtKB-ID: Q7ARJ1_YERPE
UniRef100: UniRef100_Q06131
UniRef90: UniRef90_Q06131
UniRef50: UniRef50_Q06131
UniParc: UPI00000D606B
EMBL: AE017043
EMBL: AL117189
EMBL-CDS: AAS58574.1
EMBL-CDS: CAB54905.1
RefSeq_NT: NC_003131.1
RefSeq_NT: NC_005813.1
HSSP: Q06131
GenomeReviews: AE017043_GR
GenomeReviews: AL117189_GR
KEGG: ype:YPCD1.28c
KEGG: ypm:YP_pCD55
HOGENOM: HBG299047
OMA: MAVVSGV
ProtClustDB: CLSK862121
BioCyc: YPES214092:YPCD1.28C-MONOMER
Taxonomy ID 214092
Plasmid No pCD1
Gene Starting Position 19293
Gene Ending Position 20213
Gene Strand (Orientation) -
Protein Name secreted effector protein
DNA Sequence 
>gi|16082691:19293-20213 Yersinia pestis CO92 plasmid pCD1, complete sequence
GTCAGACAACACCAAAAGCGGCTTTCATGGCGTGAGTATGACTGCTAACATATTGTTCAATCAAGCGCAG
GACATCTTTCATAAAGTTATCATTATAGTTCATCGCCTCTTCGGCTTTTTGCTTCTCGTTGGCAGCAATA
CTTGCATTGACTTCTTTCTCTTTGACCTCGGCTTGAGAATACCCTTGATGAACTTGAATCGCACTGTTTG
CCATTTGTCCTAACGGCTGCGTTGCGGCATTAAACGCATTGGCTTTTGAGTCGGTCATTCTGAATTCTTT
ATCCAATAATGCCAGCTTATTTTGATCCGCTACCTGCTCTGGTTTCCATATTCTCCCGATATCCTCTCTG
CTTACCGCTTTATCACCAATGTTACTCATTTGCTGCATTTTTGTATCAATAAGTTGTTCGCGGCCAGCAA
TATTACTGTTTAGAATTTGTTCCTGTTTAACTATTTTCACCTCTTTCGCTATAGAAAAAGCACTAGCAAC
CGTAGAAGTAGCAGCCATGATGCCAGACACCACCGCCATGGCGATCATCAGTTTTGCACCGCTGACCATC
TCCGCTACCTGCTCCTTTTGGGCAGTAATAGTAGCTTTATTTTCTATATCCCTTTGTTGCAAACCCATTT
CTCGCGCTTTACGTGCCAGTTCCAACAGCAACAACAAGATACTTAAAGTACCATTAAGATCACCCTGGCT
TTTACTCAGTAATGCAACATTGATTCCCTGGCTCGGTTTGATCAATTCTGGCACCTGTGACCGAGATAAG
CTTGCCTCGCTACTCTTTATTGCTTGTGCTTCATGACGGGTGTCTTCTGTTTTTTTAATCTCACCGCTTT
GCTTGACTGTCTCTGTAGTGATGGCATCAAGCTGTGAACCGGTCGTGATAATTGGGCTGTCTGTCTTGAT
ATTTATTGTCA
Protein Sequence 
>gi|16082716|ref|NP_395162.1| secreted effector protein [Yersinia pestis CO92] MTINIKTDSPIITTGSQLDAITTETVKQSGEIKKTEDTRHEAQAIKSSEASLSRSQVPELIKPSQGINVALLSKSQGDLNGTLSILLLLLELARKAREMGLQQRDIENKATITAQKEQVAEMVSGAKLMIAMAVVSGIMAATSTVASAFSIAKEVKIVKQEQILNSNIAGREQLIDTKMQQMSNIGDKAVSREDIGRIWKPEQVADQNKLALLDKEFRMTDSKANAFNAATQPLGQMANSAIQVHQGYSQAEVKEKEVNASIAANEKQKAEEAMNYNDNFMKDVLRLIEQYVSSHTHAMKAAFGVV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells (Rosqvist et al., 1991).
References
Rosqvist et al., 1991: Rosqvist R, Forsberg A, Wolf-Watz H. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption. Infection and immunity. 1991; 59(12); 4562-4569. [PubMed: 1937815].