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purH from Yersinia pestis Nepal516

Victor ID 1816
Gene Name purH from Yersinia pestis Nepal516
Sequence Strain (Species/Organism) Yersinia pestis Nepal516
NCBI Gene ID 4124166
NCBI Protein GI 108810403
Locus Tag YPN_0237
Protein Accession YP_646170.1
Other Database IDs UniProtKB-ID: PUR9_YERPN
UniRef100: UniRef100_A7FNG6
UniRef90: UniRef90_A1JIJ7
UniRef50: UniRef50_A9IZD0
UniParc: UPI00000CDA75
EMBL: CP000305
EMBL: ACNQ01000004
EMBL-CDS: ABG16570.1
EMBL-CDS: EEO78489.1
RefSeq_NT: NC_008149.1
GenomeReviews: CP000305_GR
KEGG: ypn:YPN_0237
eggNOG: COG0138
HOGENOM: HBG498048
OMA: ASDGFFP
ProtClustDB: PRK00881
BioCyc: YPES377628:YPN_0237-MONOMER
Taxonomy ID 377628
Gene Starting Position 290991
Gene Ending Position 292580
Gene Strand (Orientation) -
Protein Name bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
DNA Sequence 
>gi|108810166:290991-292580 Yersinia pestis Nepal516, complete genome
ATTAATGACGGAAATGGCGCATGTCGGTGAAGATCATGGCAATACTGTGTTCATCAGCAGCCGCGATGAC
TTCATCATCACGAATTGAGCCGCCCGGTTGGATGACACAAGTAATGCCCACAGCCGCGGCGGCATCAATA
CCATCACGGAACGGGAAGAAGGCATCAGAGGCCATGGCTGAGCCAGCCACTTCCAGCCCTTCATCTGCGG
CCTTGATACCGGCTATTTTCGCAGAGTACACGCGGCTCATTTGGCCGGCACCTATACCGATTGTCATGTT
ATCGCGGGCATAGACAATCGCATTGGATTTAACAAACTTAGCCACTTTCCAGCAGAACAGCGCATCACGC
AGTTCCTGTTCGGTAGGCTGACGCTTGGAAACCACGCGAAGGTCGGCCGCCGTCACCATACCTAAATCGC
GTTCTTGTACCAGCAAACCCCCATTAACACGTTTGAAATCTAAACCTGCTGAACGTGCTTGCCACTGGCC
ACAAGTCAGGACTCGGACATTTTGTTTAGCTGCAAGCAATGCCAATGCATCAGAGCTGACTGTTGGCGCA
ATGATCACTTCGACAAACTGGCGGCTGATGATCGCGCTGGCCGTTGCTGCATCCAATTCACGGTTAAAGG
CGATGATGCCACCGAAAGCTGAGGTTGGATCGGTTTGATAGGCACGTTCATAAGCGGCAAGAATAGAATC
ACCGATAGCCACACCGCATGGGTTGGCATGTTTAACGATCACACAGGCTGGTTCACTGAACTCTTTCACG
CATTCCAGCGCGGCATCGGTATCCGCAATATTGTTATAAGAGAGGGCTTTCCCTTGTAATTGCTGGGCAG
TGGCAACGGATGCCTCTTTGACATCTTCTTCTATATAGAAGGCAGCTTGCTGGTGGCTGTTTTCACCGTA
ACGCATATCCTGCTTCTTTATATAGTTAAGATTTAGGGTGCGAGGGAAGTGGCCGGAAGGCTGTTCCGTA
TCACCATGATAAGGTGGCACCAGTGTGCCGAAGTAGTTGGCGATCATGCTGTCGTAGGCGGCGGTGTGTT
CGAAAGCTTTAATGGCCAGATTGAAGCGGGTGGGGTAAGTCAACGAACCATCATTATTATCAAGCTCAGT
AATAATGGCGGGGTAGTCGCTACTCTTCACCACGATGGCGACATCTTTATGGTTCTTGGCCGCAGAGCGA
ACCATGGTTGGGCCACCAATATCAATATTCTCAACCGCATCTTCCAACGAGCAATCCGGGCGGGCAACCG
TCTGGGCGAAGGGATATAAATTAACGACGACAATATCAATGGGCTGAATGCCATGTTGAGCCATGATGCC
ATCATCCTGACCACGACGACCTAAAATCCCACCATGCACCTTTGGATGCAAAGTCTTCACACGTCCATCC
ATCATTTCCGGGAAACCGGTGTAGTCAGACACTTCGGTAACGGGTAAACCAGCATCAGCCAGCAGGCGGG
CAGTCCCACCGGTGGAAAGTAACTCGATACCGCGTTGAGAAAGTGCTTGGGCGAATTCGATGATACCTGC
TTTGTCAGACACACTGAGTAGAGCACGGCGGATTGGACGGCGTTGTTGCA
Protein Sequence 
>gi|108810403|ref|YP_646170.1| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Yersinia pestis Nepal516] MQQRRPIRRALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDGIMAQHGIQPIDIVVVNLYPFAQTVARPDCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYPAIITELDNNDGSLTYPTRFNLAIKAFEHTAAYDSMIANYFGTLVPPYHGDTEQPSGHFPRTLNLNYIKKQDMRYGENSHQQAAFYIEEDVKEASVATAQQLQGKALSYNNIADTDAALECVKEFSEPACVIVKHANPCGVAIGDSILAAYERAYQTDPTSAFGGIIAFNRELDAATASAIISRQFVEVIIAPTVSSDALALLAAKQNVRVLTCGQWQARSAGLDFKRVNGGLLVQERDLGMVTAADLRVVSKRQPTEQELRDALFCWKVAKFVKSNAIVYARDNMTIGIGAGQMSRVYSAKIAGIKAADEGLEVAGSAMASDAFFPFRDGIDAAAAVGITCVIQPGGSIRDDEVIAAADEHSIAMIFTDMRHFRH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purH mutant is attenuated in mice (Flashner et al., 2004).
COG COG0138F, under F: Nucleotide transport and metabolism
References
Flashner et al., 2004: Flashner Y, Mamroud E, Tidhar A, Ber R, Aftalion M, Gur D, Lazar S, Zvi A, Bino T, Ariel N, Velan B, Shafferman A, Cohen S. Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates. Infection and immunity. 2004; 72(2); 908-915. [PubMed: 14742535].