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yopH from Yersinia pestis KIM 10

Victor ID 2510
Gene Name yopH from Yersinia pestis KIM 10
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
NCBI Gene ID 1149274
NCBI Protein GI 31795460
Locus Tag Y0013
Protein Accession NP_857910.1
Other Database IDs UniProtKB-ID: O68720_YERPE
UniRef100: UniRef100_P08538
UniRef90: UniRef90_P08538
UniRef50: UniRef50_P15273
UniParc: UPI00000D1266
EMBL: AF053946
EMBL: AF074612
EMBL-CDS: AAC62606.1
EMBL-CDS: AAC69768.1
RefSeq_NT: NC_004836.1
RefSeq_NT: NC_004839.1
PDB: 1HUF
OMA: SAHEIAN
ProtClustDB: CLSK862151
Taxonomy ID 187410
Plasmid No pCD1
Gene Starting Position 10346
Gene Ending Position 11752
Gene Strand (Orientation) +
Protein Name secreted effector protein
DNA Sequence 
>gi|31795449:10346-11752 Yersinia pestis KIM plasmid pCD1, complete sequence
CATGAACTTATCATTAAGCGATCTTCATCGTCAGGTATCTCGATTGGTGCAGCAAGAGAGCGGTGATTGT
ACCGGGAAATTAAGAGGTAACGTTGCTGCCAATAAAGAAACTACCTTTCAAGGTTTGACCATAGCCAGTG
GAGCCAGAGAGTCAGAAAAAGTATTTGCTCAAACTGTACTAAGCCACGTAGCAAATGTTGTTCTAACTCA
AGAAGATACCGCTAAGCTATTGCAAAGTACGGTAAAGCATAATTTGAATAATTATGACTTAAGAAGTGTC
GGCAATGGTAATAGTGTACTTGTCAGTTTACGTAGTGACCAAATGACACTACAAGACGCCAAAGTGCTGT
TGGAGGCCGCATTGCGACAAGAGTCGGGAGCGAGGGGGCATGTATCATCTCATTCACATTCAGCCCTTCA
CGCACCGGGAACCCCGGTGCGTGAAGGACTGCGTTCACATCTAGACCCCAGAACTCCACCGTTGCCACCG
CGTGAACGACCACACACTTCTGGCCATCACGGGGCTGGCGAAGCCAGAGCCACCGCACCAAGCACTGTTT
CTCCTTATGGCCCAGAAGCGCGCGCAGAACTCAGCAGCCGCCTCACCACATTGCGCAATACGCTGGCGCC
AGCAACGAATGATCCGCGTTACTTACAAGCCTGCGGCGGTGAAAAGCTAAACCGATTTAGAGATATTCAA
TGCTGTCGGCAAACCGCAGTACGCGCCGATCTTAATGCCAATTACATCCAGGTCGGTAACACTCGTACCA
TAGCGTGCCAGTATCCGCTACAATCTCAACTTGAAAGCCATTTCCGTATGCTGGCAGAAAACCGAACGCC
AGTGTTGGCTGTTTTAGCGTCCAGTTCTGAGATAGCCAATCAAAGATTCGGTATGCCAGATTATTTCCGC
CAGAGTGGTACCTATGGCAGTATCACTGTAGAGTCTAAAATGACTCAGCAAGTTGGTCTCGGTGACGGGA
TTATGGCAGATATGTATACTTTAACGATTCGTGAAGCGGGTCAAAAAACAATCTCTGTTCCTGTGGTTCA
TGTTGGCAATTGGCCCGATCAGACCGCAGTCAGCTCTGAAGTTACCAAGGCACTCGCTTCACTGGTAGAT
CAAACAGCAGAAACAAAACGCAATATGTATGAAAGCAAAGGAAGTTCAGCGGTAGGAGATGACTCCAAAT
TACGGCCGGTAATACATTGCCGTGCGGGTGTTGGCCGTACTGCGCAACTGATTGGCGCAATGTGCATGAA
TGATAGTCGTAATAGTCAGTTAAGCGTAGAAGATATGGTCAGCCAAATGCGAGTACAAAGAAATGGTATT
ATGGTACAAAAAGATGAGCAACTTGATGTTCTGATTAAGTTGGCTGAAGGACAAGGGCGACCATTATTAA
ATAGCTA
Protein Sequence 
>gi|31795460|ref|NP_857910.1| targeted effector protein [Yersinia pestis] MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANVVLTQEDTAKLLQSTVKHNLNNYDLRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSALHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVGDDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis (Andersson et al., 1996).
References
Andersson et al., 1996: Andersson K, Carballeira N, Magnusson KE, Persson C, Stendahl O, Wolf-Watz H, Fällman M. YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis. Molecular microbiology. 1996; 20(5); 1057-1069. [PubMed: 8809758].