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dnaE from Yersinia pestis CO92

Victor ID 1137
Gene Name dnaE from Yersinia pestis CO92
Sequence Strain (Species/Organism) Yersinia pestis CO92
NCBI Gene ID 1173899
NCBI Protein GI 16121359
Locus Tag YPO1059
Protein Accession NP_404672.1
Other Database IDs UniProtKB-ID: Q7CH18_YERPE
UniRef100: UniRef100_A9R381
UniRef90: UniRef90_A9R381
UniRef50: UniRef50_Q89AN8
UniParc: UPI00000DCA59
EMBL: AE009952
EMBL: AE017042
EMBL: AL590842
EMBL-CDS: AAM86670.1
EMBL-CDS: AAS62975.1
EMBL-CDS: CAL19724.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
RefSeq_NT: NC_003143.1
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
GenomeReviews: AL590842_GR
KEGG: ype:YPO1059
KEGG: ypk:y3120
KEGG: ypm:YP_2791
HOGENOM: HBG734490
OMA: QIVTFGT
ProtClustDB: PRK05673
BioCyc
Taxonomy ID 214092
Gene Starting Position 1200845
Gene Ending Position 1204360
Gene Strand (Orientation) +
Protein Name DNA polymerase III subunit alpha
DNA Sequence 
>gi|16120353:1200845-1204360 Yersinia pestis CO92 chromosome, complete genome
TATGATTCAATCCACTCATTTCTGGTATCTGGATATGGCCGAACCTCGTTTTGTCCACCTGCGTGTTCAT
AGCGATTATTCCATGATCGATGGATTAGCTAAGATTGGACCTTTGGTGAAAAGAGCTGCTGCATTAGGTA
TGCCTGCTCTGGCTATTACCGATTTTACTAACCTCTGTGGCCTGGTGAAATTCTACGGCAGCGCGCATGG
TGCGGGGATTAAACCCATCATCGGTGCTGACTTCTACGTACAAAGTGAAATACTGGGTGATGAATTAGCT
CACCTCACGGTTTTGGCTCGCAATAATGAAGGCTATCAAAATCTGACTTTATTGATCTCAGAAGCCTACC
AACGGGGTTATGGCGCTGCGGGTCCTATCATTGATCGCGATTGGCTGATCAAACATAAAGAAGGACTCAT
TCTGCTGTCTGGTGGCCGAATGGGGGATGTGGGCAAATTTCTGCTACGGGGTAACCAGGTTCAGGTTGAT
CAATGTCTCGCCTTTTATCAGGAACACTTTCCAGACTGCTATTACCTCGAACTTATTCGAACCGGGCGTC
CAGACGAAGAAAACTATCTTCATGCTGCCGTGGCATTGGCCACTGAGCGTGGTTTACCTGTCGTTGCGAC
CAATGATGTGCGTTTTATTGATGAATCGGATTTTGATGCCCATGAAATCCGTGTCGCTATCCATGATGGT
TTTACATTGGTCGATCCTAAACGGCCGAAGAATTACAGCCCTCAGCAGTTTATGCGCGATGAAGAACAGA
TGTGTGAGCTGTTCGCTGATATTCCAGAAGCGTTGATCAACAGCGTTGAGATAGCCAAACGCTGTAATGT
CACTATTCGCCTTGGGGAATATTTCTTACCGCAGTTCCCCACAGGGGAGATGAGTACAGAAGATTTTCTG
GTAGAAAAAGCCAAACAAGGTTTGGAAGAACGTTTGGAATTTCTGTTTCCGGACCCTGAGGTTAGGCTGC
AAAAACGGCCAGAATATGATGAACGTCTGGATATCGAGCTCAAAGTTATCAACCAAATGGGCTTCCCTGG
TTACTTCCTGATTGTAATGGAGTTTATCCAGTGGTCGAAAGATAACGGCGTACCGGTGGGGCCGGGGCGT
GGCTCTGGTGCAGGCTCATTGGTGGCTTATGCCCTGAAAATTACTGATATTGACCCACTGGAATTTGATC
TACTGTTCGAGCGCTTCCTTAATCCGGAACGTGTATCGATGCCTGACTTCGACGTTGACTTCTGTATGGA
GAAACGTGATCTGGTGATCGAACACGTGGCGGAAATGTATGGCCGCGATGCGGTTTCCCAGATAATTACC
TTCGGTACCATGGCGGCTAAAGCGGTCATCCGCGATGTCGGCCGTGTATTAGGCCATCCCTATGGCTTTG
TTGATCGGATCTCAAAATTAATCCCACTCGATCCGGGGATGACACTGGAAAAAGCGTTTGCAGCGGAGCC
ACAGCTAGCTGAAATTTATGAAGCTGATGAAGAGGTCAGGGCGCTAATTGATATGGCGCGTAAGCTGGAA
GGAGTAACGCGAAACGCCGGGAAACATGCTGGAGGCGTGGTTATTGCCCCCACTAAGATTACCGATTTTG
CCCCACTCTATTGTGATGCGGAAGGCAATAACCCAGTTACGCAGTTTGATAAAAATGATGTGGAATATGC
TGGGCTGGTGAAGTTTGACTTCCTCGGTCTACGTACACTAACCATCATTAATTGGGCGTTGGAGATGATT
AACGCCCGGCGCGCTAAAACTGGATTGGAACCCATTGATATCGCCTCTATTCCGCTGGAGGATAAAAAAA
GCTTCGATATGCTGCAACGTTCGGAAACGACAGCAGTATTCCAGCTGGAATCCAGAGGGATGAAAGACTT
GATCAAGCGCCTGAAGCCCGACTGCTTCGAGGACATGATCGCCTTAGTGGCGTTATTTCGTCCCGGTCCG
TTACAATCAGGGATGGTTGATAACTTTATTGACCGTAAACACGGCCGGGAAGCGATATCTTACCCAGATA
TTGAGTGGCAACATGAATCCTTGAAACCTGTGCTTGAGCCGACCTACGGCATTATCTTGTATCAGGAACA
GGTCATGCAAATTGCGCAGGTTCTGTCCGGCTACTCACTGGGTGGTGCGGACATGTTGCGTCGTGCCATG
GGTAAGAAAAACCCTGCTGAGATGGCTAAGCAGCGTTCTGTATTTGAAGATGGTGCGAAAAATCAGGGTA
TTGATGGTGAGCTGGCGATTAAAATCTTTGACCTGGTTGAGAAATTTGCAGGTTACGGTTTTAACAAATC
TCACTCGGCAGCTTATGCATTAGTCTCCTATCAAACGTTGTGGTTAAAAGCCCATTATCCGGCTGAATTT
ATGGCTGCAGTAATGACCGCTGATATGGATAATACGGACAAAGTGGTCGGCTTGGTCGATGAATGCTGGC
GTATGGGGCTGAAAATTCTGCCCCCTGACATCAACAGCGGTTTGTACCATTTCCATGTAAACGATGATGG
CGAAATTGTTTATGGTATTGGTGCCATTAAAGGTGTAGGTGAGGGGCCGATAGAAGCCATTCTGGAGGCG
CGTAAAGAGGGGGGCTATTTTAAAGAGTTATTTGACCTATGCGCCCGTGTCGATACCAAAAAGCTTAACA
AGCGTATTTTAGAAAAACTGATCATGTCCGGTGCATTTGACCGTTTGGGGCCACACCGTGCAGCATTGAT
GAGTTCTCTCGGGGATGCGCTTAAAGCCGCAGATCAACATGCTAAAGCCGAAGCAATTGGTCAGGTAGAT
ATGTTTGGTGTATTAGCCGACGCGCCTGAGCAGGTTGAGCAATCCTATGCCAATGTGCCGCCATGGCAGG
AGCAGGTTGTTTTAGATGGTGAACGGGAAACGCTGGGGCTGTATTTAACTGGCCATCCGATCACTCAGTA
CCTCAAGGAAATCGAACGCTATGCCGGTGGGATGCGTTTGAAGGATATGCATCCGACGGATCGGGGCAAA
ATGACCACCGCAGTGGGGTTGGTGATCGCGGCAAGGGTTATGGTCACAAAACGTGGTAATCGCATTGGTA
TTTGTACGCTAGATGACCGCTCTGGTCGTCTGGAGGTGATGTTATTCACCGATGCATTGGAAAAATATCA
GCATTTATTGGAAAAAGACCGTATCCTGATAGCCACCGGACAGGTCAGCTTTGATGACTTTAGTGGTGGG
CTTAAAATGACCGCCCGTGAGTTAATGGACATCAGTGAAGCTCGTGAAAAATATGCAAGTGGGCTTGCTA
TCTCGCTGACTGACAGGCAAATTGATGACCAGCTTTTGAACCGTCTCCGTCAGTCGTTGGAACCCCATCG
AGCGGGGACGATCCCAGTACATCTTTATTACCAACGGGAAGATGCTCGCGCCCGGCTGCGGTTTGGAGCC
ACATGGCGCGTGACGCCCACCGATCGCTTATTAATCGATTTGCGAACGTTGGTAGGTAATGAGCAAGTGG
AACTGGAATTTGACTA
Protein Sequence 
>gi|218928227|ref|YP_002346102.1| DNA polymerase III subunit alpha [Yersinia pestis CO92] MIQSTHFWYLDMAEPRFVHLRVHSDYSMIDGLAKIGPLVKRAAALGMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFYVQSEILGDELAHLTVLARNNEGYQNLTLLISEAYQRGYGAAGPIIDRDWLIKHKEGLILLSGGRMGDVGKFLLRGNQVQVDQCLAFYQEHFPDCYYLELIRTGRPDEENYLHAAVALATERGLPVVATNDVRFIDESDFDAHEIRVAIHDGFTLVDPKRPKNYSPQQFMRDEEQMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQFPTGEMSTEDFLVEKAKQGLEERLEFLFPDPEVRLQKRPEYDERLDIELKVINQMGFPGYFLIVMEFIQWSKDNGVPVGPGRGSGAGSLVAYALKITDIDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDLVIEHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPLDPGMTLEKAFAAEPQLAEIYEADEEVRALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNNPVTQFDKNDVEYAGLVKFDFLGLRTLTIINWALEMINARRAKTGLEPIDIASIPLEDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREAISYPDIEWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYSLGGADMLRRAMGKKNPAEMAKQRSVFEDGAKNQGIDGELAIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAILEARKEGGYFKELFDLCARVDTKKLNKRILEKLIMSGAFDRLGPHRAALMSSLGDALKAADQHAKAEAIGQVDMFGVLADAPEQVEQSYANVPPWQEQVVLDGERETLGLYLTGHPITQYLKEIERYAGGMRLKDMHPTDRGKMTTAVGLVIAARVMVTKRGNRIGICTLDDRSGRLEVMLFTDALEKYQHLLEKDRILIATGQVSFDDFSGGLKMTARELMDISEAREKYASGLAISLTDRQIDDQLLNRLRQSLEPHRAGTIPVHLYYQREDARARLRFGATWRVTPTDRLLIDLRTLVGNEQVELEFD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: dnaE mutant is attenuated in mice (Flashner et al., 2004).
References
Flashner et al., 2004: Flashner Y, Mamroud E, Tidhar A, Ber R, Aftalion M, Gur D, Lazar S, Zvi A, Bino T, Ariel N, Velan B, Shafferman A, Cohen S. Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates. Infection and immunity. 2004; 72(2); 908-915. [PubMed: 14742535].