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phoP from Yersinia pestis biovar Microtus str. 91001

Victor ID 2553
Gene Name phoP from Yersinia pestis biovar Microtus str. 91001
Sequence Strain (Species/Organism) Yersinia pestis biovar Microtus str. 91001
NCBI Gene ID 2765857
NCBI Protein GI 45441575
Locus Tag YP_1764
Protein Accession NP_993114.1
Other Database IDs UniProtKB-ID: Q74UF9_YERPE
UniRef100: UniRef100_A4TLN7
UniRef90: UniRef90_D5B7T7
UniRef50: UniRef50_Q5PMJ1
UniParc: UPI00000BA5E2
EMBL: AE017042
EMBL-CDS: AAS61991.1
RefSeq_NT: NC_005810.1
HSSP: P08402
GenomeReviews: AE017042_GR
KEGG: ypm:YP_1764
HOGENOM: HBG753323
ProtClustDB: PRK10816
Taxonomy ID 229193
Gene Starting Position 1956158
Gene Ending Position 1956829
Gene Strand (Orientation) -
Protein Name DNA-binding response regulator in two-component regulatory system with PhoQ
DNA Sequence 
>gi|45439865:1956158-1956829 Yersinia pestis biovar Microtus str. 91001 chromosome, complete genome
TCTAGTTGACGTCAAAACGATATCCCTGACCACGAATAGTCGTAATGACTTCACCCTGATGTTCTGCCAG
CAGTTTTTTACGTAGTCGACCCATTAATACATCGATAGTATGGCTCTCTCGCAATTCCGCATCCGGATAA
AGTTGTAGCATCAACGTATCCTTACTAACGACTTTCCCTGCGTTGCGGATAAGGGTTTCAATGATAGTGT
ATTCAAATGCCGTCAGTTTAATTTGTTGTTGGTTAACACATAACTCACGGCGTGAAAGGTCAATCTGGAA
GGGCGGTAGCTCAATAATTTGGGAGGCCAGGCCAATATTCCGCCGCATCAGTGCTTGCATCCGGGCAATG
ACCTCTTCCAGATGGAACGGTTTGGTCACATAATCGTCGGCACCGGCTTCCAGTACAGCGACTTTATCTT
GCCAGCTTTCCCGTGCGGTCAGGACCAAAATGGGTAAGTTTTCTTGATGGCTACGCCAGCGACGGATAAG
GCTTAACCCGTCTTCACCGGGCAAACCAAGATCGATAATAGCAATGTCGGGGGCATGCTCTTGTAAGAAA
TAGTCTGCTTCTTTAGCATCTTCCGCGGCATCAACCTGATGGCCCATTTCACGCATTTGCACTGTCAGAT
GGTGACGCAACAACGCGTTATCTTCCACAACCAGAACCCGCA
Protein Sequence 
>gi|45441575|ref|NP_993114.1| DNA-binding transcriptional regulator PhoP [Yersinia pestis biovar Microtus str. 91001] MRVLVVEDNALLRHHLTVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIIDLGLPGEDGLSLIRRWRSHQENLPILVLTARESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNIGLASQIIELPPFQIDLSRRELCVNQQQIKLTAFEYTIIETLIRNAGKVVSKDTLMLQLYPDAELRESHTIDVLMGRLRKKLLAEHQGEVITTIRGQGYRFDVN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain (Oyston et al., 2000).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Oyston et al., 2000: Oyston PC, Dorrell N, Williams K, Li SR, Green M, Titball RW, Wren BW. The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis. Infection and immunity. 2000; 68(6); 3419-3425. [PubMed: 10816493].