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phoP from Yersinia pestis CO92

Victor ID 1145
Gene Name phoP from Yersinia pestis CO92
Sequence Strain (Species/Organism) Yersinia pestis CO92
NCBI Gene ID 1174473
NCBI Protein GI 16121902
Locus Tag YPO1634
Protein Accession NP_405215.1
Other Database IDs UniProtKB-ID: P74992_YERPE
UniRef100: UniRef100_D5B7T7
UniRef90: UniRef90_D5B7T7
UniRef50: UniRef50_Q5PMJ1
UniParc: UPI00000DC749
EMBL: AE009952
EMBL: Y08758
EMBL: AL590842
EMBL-CDS: AAM85362.1
EMBL-CDS: CAA70004.1
EMBL-CDS: CAL20279.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_003143.1
HSSP: P08402
GenomeReviews: AE009952_GR
GenomeReviews: AL590842_GR
KEGG: ype:YPO1634
KEGG: ypk:y1794
HOGENOM: HBG753323
OMA: HIEEVVA
ProtClustDB: PRK10816
BioCyc: YPES187410:Y1794-MONOMER
Taxonomy ID 214092
Gene Starting Position 1859916
Gene Ending Position 1860587
Gene Strand (Orientation) -
Protein Name DNA-binding response regulator in two-component regulatory system with PhoQ
DNA Sequence 
>gi|16120353:1859916-1860587 Yersinia pestis CO92 chromosome, complete genome
TCTAGTTGACGTCAAAACGATATCCCTGACTACGAATAGTCGTAATGACTTCACCCTGATGTTCTGCCAG
CAGTTTTTTACGTAGTCGACCCATTAATACATCGATAGTATGGCTCTCTCGCAATTCCGCATCCGGATAA
AGTTGTAGCATCAACGTATCCTTACTAACGACTTTCCCTGCGTTGCGGATAAGGGTTTCAATGATAGTGT
ATTCAAATGCCGTCAGTTTAATTTGTTGTTGGTTAACACATAACTCACGGCGTGAAAGGTCAATCTGGAA
GGGCGGTAGCTCAATAATTTGGGAGGCCAGGCCAATATTCCGCCGCATCAGTGCTTGCATCCGGGCAATG
ACCTCTTCCAGATGGAACGGTTTGGTCACATAATCGTCGGCACCGGCTTCCAGTACAGCGACTTTATCTT
GCCAGCTTTCCCGTGCGGTCAGGACCAAAATGGGTAAGTTTTCTTGATGGCTACGCCAGCGACGGATAAG
GCTTAACCCGTCTTCACCGGGCAAACCAAGATCGATAATAGCAATGTCGGGGGCATGCTCTTGTAAGAAA
TAGTCTGCTTCTTTAGCATCTTCCGCGGCATCAACCTGATGGCCCATTTCACGCATTTGCACTGTCAGAT
GGTGACGCAACAACGCGTTATCTTCCACAACCAGAACCCGCA
Protein Sequence 
>gi|218928770|ref|YP_002346645.1| DNA-binding transcriptional regulator PhoP [Yersinia pestis CO92] MRVLVVEDNALLRHHLTVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIIDLGLPGEDGLSLIRRWRSHQENLPILVLTARESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNIGLASQIIELPPFQIDLSRRELCVNQQQIKLTAFEYTIIETLIRNAGKVVSKDTLMLQLYPDAELRESHTIDVLMGRLRKKLLAEHQGEVITTIRSQGYRFDVN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain (Oyston et al., 2000).
References
Oyston et al., 2000: Oyston PC, Dorrell N, Williams K, Li SR, Green M, Titball RW, Wren BW. The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis. Infection and immunity. 2000; 68(6); 3419-3425. [PubMed: 10816493].