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y3857

Victor ID 795
Gene Name y3857
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
NCBI Gene ID 1148804
NCBI Protein GI 22127728
Locus Tag y3857
Genbank Accession AE009952
Protein Accession NP_671151
Other Database IDs UniProtKB-ID: Q7CG03_YERPE
UniRef100: UniRef100_D1Q1W2
UniRef90: UniRef90_D1Q1W2
UniRef50: UniRef50_B2K6K5
UniParc: UPI00000DCB51
EMBL: AE009952
EMBL: AE017042
EMBL: AL590842
EMBL-CDS: AAM87402.1
EMBL-CDS: AAS63500.1
EMBL-CDS: CAL22553.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
RefSeq_NT: NC_003143.1
HSSP: O69771
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
GenomeReviews: AL590842_GR
KEGG: ype:YPO3973
KEGG: ypk:y3857
KEGG: ypm:YP_3335
HOGENOM: HBG598843
OMA: TYAEDTR
ProtClustDB: CL
Taxonomy ID 187410
Gene Starting Position 4295302
Gene Ending Position 4296639
Gene Strand (Orientation) -
Protein Name metalloprotease
Protein pI 5.88
Protein Weight 48029.23
Protein Length 445
Protein Note residues 41 to 439 of 445 are 45.49 pct identical to residues 57 to 477 of 477 from GenPept : >emb|CAC39217.1| (AJ318052) metalloprotease p1 [Yersinia ruckeri]
DNA Sequence 
>gi|22123922:4295302-4296639 Yersinia pestis KIM 10 chromosome, complete genome
TTTATGCCGTCAGTGACGTACTTAAAATAAAGTCATTGGCGGTGAAATGGTGCCTGCCGGTAAATTTAAT
CATCATATCGCACTCGCTGACTTGAGCGTCAAAATCAATCATAAGATAAGTTATGTCCGCCACTTCATTA
TATTGCTGCCCCATCTCTGTTTGACCGTTAAAACTTAATCTATCGACAAAAATAACACGGTCGGTTGAGG
GCATTAATTGCGACAAATCTATCTTGTCACGGCCTGATTTAAAATCATGAATAGTATCGGGCGAGGTGGT
CATTGAATCTCTGGCACTGGCATAGCGGAAAGTATTATTGCCCCCGTTACCCCAAAGTTGATCAGATCCG
CCGTTACCGGTCAAAATATTATTGGTGTGATTGCCGATAATATCATCATGGCCACTGCCGCCGATGGCAT
TTTCAATCGTAACATCCGCTGCAATAGACACATTTCCTTTTAGTCCACCAACATCAGAAAAACAGAGTTC
GTTAAGATTAATCATTTGATTTTGCTTATAGCCAGAGAAGTCAAAAGTATCATTGCCGCCAGCATCCCAG
ACACAGAAAATCAACGCATCACTGGCGTGGGTGGCGGTGAAATGATCTCTATAACTCGTCGAGTTGAAGC
CATAAACGGTATCACCGGTGCGGGTGTGTAGATTGGCCCCATACAGATACTGGATTGCGGCGATATCGTA
CATTTGTGGTGTGGATAAGTAATGTTGGCCATAATTTGCACCTGAACCCTGTTCGGATAAATAGCTCATT
ACACTCATTTGCTGTGTATAGCCATGGGGGGCATGAGAATGACCCAACCCCAGAGCATGGCCGATCTCAT
GTGTTAATACTCCGCCACCATCATTTAATCTGCTGGGATGTTGGTTATCGCTGAAACTGTAATTAATCCA
TATTGGGCTGAAGCTACCTGGATTAGGATAATAGGCATAACCTGCCACATTACTTGGGCGCTGAAAATTT
AAAAATAGAATATTGGCGGAGGAGTCTGCTGATGCTTCGGTGAAGGAGATGTTGGCTACATCAGCCCAAG
ATTGCATCGCGATTTTTGCCTGATGGATTTGGGCTGGATTAAATAATGAGATGTAAGCGTTCTGTTGGAA
TGTTCGATCATAATCCCATAATGTATAGGCTCGACTAAATGAATATGTCAGGTTTGTATTTTTATTATGA
ATGGTGTTTTCTTTCCATGACTGACGGCTAGATATTTGTGGTGCTATAACACCTTTAACTTCATTCTTAT
AATGAATGCCTCTACGCATGACCTGTTCATTTTTAATTATAGTATTGCTGTATTCCCTGGAGTAACTCAT
AAACATCA
Protein Sequence 
>gi|22127728|ref|NP_671151.1| metalloprotease [Yersinia pestis KIM 10]
MMFMSYSREYSNTIIKNEQVMRRGIHYKNEVKGVIAPQISSRQSWKENTIHNKNTNLTYSFSRAYTLWDY
DRTFQQNAYISLFNPAQIHQAKIAMQSWADVANISFTEASADSSANILFLNFQRPSNVAGYAYYPNPGSF
SPIWINYSFSDNQHPSRLNDGGGVLTHEIGHALGLGHSHAPHGYTQQMSVMSYLSEQGSGANYGQHYLST
PQMYDIAAIQYLYGANLHTRTGDTVYGFNSTSYRDHFTATHASDALIFCVWDAGGNDTFDFSGYKQNQMI
NLNELCFSDVGGLKGNVSIAADVTIENAIGGSGHDDIIGNHTNNILTGNGGSDQLWGNGGNNTFRYASAR
DSMTTSPDTIHDFKSGRDKIDLSQLMPSTDRVIFVDRLSFNGQTEMGQQYNEVADITYLMIDFDAQVSEC
DMMIKFTGRHHFTANDFILSTSLTA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: y3857 mutant is attenuated in mice (Flashner et al., 2004).
COG COG2931Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Flashner et al., 2004: Flashner Y, Mamroud E, Tidhar A, Ber R, Aftalion M, Gur D, Lazar S, Zvi A, Bino T, Ariel N, Velan B, Shafferman A, Cohen S. Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates. Infection and immunity. 2004; 72(2); 908-915. [PubMed: 14742535].