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spoT from Yersinia pestis KIM 10

Victor ID 759
Gene Name spoT from Yersinia pestis KIM 10
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
NCBI Gene ID 1145050
NCBI Protein GI 22124023
Locus Tag y0103
Protein Accession NP_667446.1
Other Database IDs UniProtKB-ID: Q7CLB1_YERPE
UniRef100: UniRef100_A4TSE8
UniRef90: UniRef90_P0AG25
UniRef50: UniRef50_P0AG25
UniParc: UPI00000DCD6C
EMBL: AE009952
EMBL: AE017042
EMBL: AL590842
EMBL-CDS: AAM83697.1
EMBL-CDS: AAS60320.1
EMBL-CDS: CAL18728.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
RefSeq_NT: NC_003143.1
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
GenomeReviews: AL590842_GR
KEGG: ype:YPO0038
KEGG: ypk:y0103
KEGG: ypm:YP_0039
HOGENOM: HBG594146
OMA: ARTAIRH
ProtClustDB: PRK11092
BioCyc
Taxonomy ID 187410
Gene Starting Position 108966
Gene Ending Position 111074
Gene Strand (Orientation) +
Protein Name bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
DNA Sequence 
>gi|22123922:108966-111074 Yersinia pestis KIM 10 chromosome, complete genome
TTTGTACCTGTTTGAAAGCCTGAATCTGCTGATTCAACGTTACCTGCCAGAGGAGCAGATTAAGCGCCTC
AAACAGGCATATCTTGTCGCACGTGATGCTCACGAGGGGCAGACACGCTCCAGCGGTGAGCCTTATATCA
CTCACCCGGTTGCTGTGGCCTGTATTCTCGCGGAGATGCGGCTCGACTACGAAACCTTAATGGCGGCGCT
ATTACATGACGTCATTGAAGATACACCTGCTACATATCAAGATATGGAACAGCTGTTTGGGAAAAGCGTA
GCCGAGTTAGTCGAGGGTGTATCTAAACTCGATAAACTGAACTTCCGTGACAAGAAAGAAGCCCAGGCGG
AAAACTTCCGCAAAATGATCATGGCAATGGTGCAAGACATCCGCGTCATTTTGATCAAACTGGCTGACCG
TACACACAATATGCGCACACTGGGCTCTTTGCGCCCGGATAAACGTCGGCGCATTGCTCGCGAAACCCTT
GAGATATACAGCCCACTAGCCCACCGGCTGGGTATTCATCATTTAAAAACCGAGCTGGAAGAGCTGGGTT
TTGAAGCACTCTATCCCAATCGTTACCGCGTCATTAAAGAAGTGGTAAAAGCCGCGCGCGGTAACCGCAA
AGAGATGATTCAGAAGATCCTCGCGGAGATTGAAGGGCGCTTGACCGAGGCTGGCATTCCTTGCCGGGTC
AGTGGCCGTGAGAAGCATCTGTATTCCATCTACTGCAAGATGCACCTGAAAGAACAGCGCTTCCATTCCA
TCATGGATATCTATGCTTTTCGGGTTATCGTCAAAGAAGTCGATACTTGCTACCGCGTGTTGGGGCAGGC
TCATAGCCTGTATAAACCCCGCCCTGGGCGCGTAAAAGACTATATCGCTATCCCTAAAGCTAACGGCTAC
CAATCATTACATACGTCATTAATCGGTCCCCATGGCGTACCGGTAGAAGTACAAATCCGTACTGAAGATA
TGGACCAGATGGCCGAAATGGGGGTTGCTGCACACTGGGCTTATAAAGAACAAGGTGAGTCCGGTACCAC
GGCTCAAATCCGTGCTCAGCGGTGGATGCAAAGCTTGCTGGAGTTACAACAAAGCGCGGGTAGCTCATTT
GAATTTATTGAAAGCGTGAAATCTGATTTATTCCCTGATGAGATCTACGTTTTCACCCCGGAAGGGCGCA
TTGTGGAATTACCGGCTGGTGCCACACCGGTCGATTTTGCCTATGTTGTGCATACCGATATCGGCCATGC
CTGCGTAGGTGCCCGCGTTGATCGTCAGCCGTACCCGCTCTCTCAGCCACTGAGTAGTGGCCAGACGGTT
GAGATTATTACCGCTCCAGGAGCCAGACCAAATGCTGCCTGGCTGAATTTTGTCGTCAGTTCAAAAGCGC
GAGCCAAAATACGTCAATTACTGAAAAATCTTAAACGTGATGAATCGGTCAGCCTTGGTCGCCGGTTACT
GAATCATGCATTAGGAAATGGGCGTAAACTCTCTGATATTTCTGAAGAAAATATCAAACACGAGTTGGAT
AGAATGAAACTGGCTACGGTAGATGACTTGCTGGCAGAAATTGGTTTAGGTAATGCCATGAGCGTAGTGG
TGGCTAAAAACCTATTGGGCGATCCATCAACACTGGGCACCTCTGCTTCTGGTACCCGCAAGTTACCGAT
CAAAGGTGCCGATGGCGTACTTATCACGTTTGCCAAGTGCTGCCGTCCAATCCCTGGTGACCCTATTATC
GCCCATATCAGCCCAGGTAAAGGGTTGGTTATTCATCACGAATCTTGTCGGAATATCCGTGGTTACCAGA
AAGAGCCTGAGAAATTTATGGCTGTAGAATGGGACCAAGAGACTGAACAAGAGTTTATTGCCGAAATTAA
AGTCGATATGTTTAACCAACAAGGTGCGCTTGCCAATCTGACCGCCGCGATTAACGCCGCCGAATCCAAT
ATTCAGAGTTTGAATACAGAAGAAAAAGATGGCCGGGTATACAGCGCCTTTATTCGCCTGACCACTCGGA
ACCGGGTCCATCTGGCTAACATTATGCGTAAAATCCGTATCATGCCAGATGTGGTTAAAGTTAGCCGTAA
TCGCAATTA
Protein Sequence 
>gi|22124023|ref|NP_667446.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase [Yersinia pestis KIM10+] MYLFESLNLLIQRYLPEEQIKRLKQAYLVARDAHEGQTRSSGEPYITHPVAVACILAEMRLDYETLMAALLHDVIEDTPATYQDMEQLFGKSVAELVEGVSKLDKLNFRDKKEAQAENFRKMIMAMVQDIRVILIKLADRTHNMRTLGSLRPDKRRRIARETLEIYSPLAHRLGIHHLKTELEELGFEALYPNRYRVIKEVVKAARGNRKEMIQKILAEIEGRLTEAGIPCRVSGREKHLYSIYCKMHLKEQRFHSIMDIYAFRVIVKEVDTCYRVLGQAHSLYKPRPGRVKDYIAIPKANGYQSLHTSLIGPHGVPVEVQIRTEDMDQMAEMGVAAHWAYKEQGESGTTAQIRAQRWMQSLLELQQSAGSSFEFIESVKSDLFPDEIYVFTPEGRIVELPAGATPVDFAYVVHTDIGHACVGARVDRQPYPLSQPLSSGQTVEIITAPGARPNAAWLNFVVSSKARAKIRQLLKNLKRDESVSLGRRLLNHALGNGRKLSDISEENIKHELDRMKLATVDDLLAEIGLGNAMSVVVAKNLLGDPSTLGTSASGTRKLPIKGADGVLITFAKCCRPIPGDPIIAHISPGKGLVIHHESCRNIRGYQKEPEKFMAVEWDQETEQEFIAEIKVDMFNQQGALANLTAAINAAESNIQSLNTEEKDGRVYSAFIRLTTRNRVHLANIMRKIRIMPDVVKVSRNRN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009).
COG COG0317TK, under T: Signal transduction mechanisms; K: Transcription
References
Sun et al., 2009: Sun W, Roland KL, Branger CG, Kuang X, Curtiss R 3rd. The role of relA and spoT in Yersinia pestis KIM5 pathogenicity. PloS one. 2009; 4(8); e6720. [PubMed: 19701461].