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phoP from Yersinia pestis Angola

Victor ID 1954
Gene Name phoP from Yersinia pestis Angola
Sequence Strain (Species/Organism) Yersinia pestis Angola
NCBI Gene ID 5801327
NCBI Protein GI 162418657
Locus Tag YpAngola_A2855
Protein Accession YP_001607237.1
Other Database IDs UniProtKB-ID: A9R0L9_YERPG
UniRef100: UniRef100_A4TLN7
UniRef90: UniRef90_D5B7T7
UniRef50: UniRef50_Q5PMJ1
UniParc: UPI00000BA5E2
EMBL: CP000901
EMBL-CDS: ABX85420.1
RefSeq_NT: NC_010159.1
GenomeReviews: CP000901_GR
KEGG: ypg:YpAngola_A2855
HOGENOM: HBG753323
OMA: HIEEVVA
ProtClustDB: PRK10816
BioCyc: YPES349746:YPANGOLA_A2855-MONOMER
Taxonomy ID 349746
Gene Starting Position 2995685
Gene Ending Position 2996356
Gene Strand (Orientation) +
Protein Name transcriptional regulatory protein PhoP
DNA Sequence 
>gi|162418099:2995685-2996356 Yersinia pestis Angola, complete genome
TATGCGGGTTCTGGTTGTGGAAGATAACGCGTTGTTGCGTCACCATCTGACAGTGCAAATGCGTGAAATG
GGCCATCAGGTTGATGCCGCGGAAGATGCTAAAGAAGCAGACTATTTCTTACAAGAGCATGCCCCCGACA
TTGCTATTATCGATCTTGGTTTGCCCGGTGAAGACGGGTTAAGCCTTATCCGTCGCTGGCGTAGCCATCA
AGAAAACTTACCCATTTTGGTCCTGACCGCACGGGAAAGCTGGCAAGATAAAGTCGCTGTACTGGAAGCC
GGTGCCGACGATTATGTGACCAAACCGTTCCATCTGGAAGAGGTCATTGCCCGGATGCAAGCACTGATGC
GGCGGAATATTGGCCTGGCCTCCCAAATTATTGAGCTACCGCCCTTCCAGATTGACCTTTCACGCCGTGA
GTTATGTGTTAACCAACAACAAATTAAACTGACGGCATTTGAATACACTATCATTGAAACCCTTATCCGC
AACGCAGGGAAAGTCGTTAGTAAGGATACGTTGATGCTACAACTTTATCCGGATGCGGAATTGCGAGAGA
GCCATACTATCGATGTATTAATGGGTCGACTACGTAAAAAACTGCTGGCAGAACATCAGGGTGAAGTCAT
TACGACTATTCGTGGTCAGGGATATCGTTTTGACGTCAACTA
Protein Sequence 
>gi|162418657|ref|YP_001607237.1| DNA-binding transcriptional regulator PhoP [Yersinia pestis Angola] MRVLVVEDNALLRHHLTVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIIDLGLPGEDGLSLIRRWRSHQENLPILVLTARESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNIGLASQIIELPPFQIDLSRRELCVNQQQIKLTAFEYTIIETLIRNAGKVVSKDTLMLQLYPDAELRESHTIDVLMGRLRKKLLAEHQGEVITTIRGQGYRFDVN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain (Oyston et al., 2000).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Oyston et al., 2000: Oyston PC, Dorrell N, Williams K, Li SR, Green M, Titball RW, Wren BW. The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis. Infection and immunity. 2000; 68(6); 3419-3425. [PubMed: 10816493].