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purH from Yersinia pestis biovar Microtus str. 91001

Victor ID 2552
Gene Name purH from Yersinia pestis biovar Microtus str. 91001
Sequence Strain (Species/Organism) Yersinia pestis biovar Microtus str. 91001
NCBI Gene ID 2765673
NCBI Protein GI 45442845
Locus Tag YP_3091
Protein Accession NP_994384.1
Other Database IDs UniProtKB-ID: PUR9_YERPE
UniRef100: UniRef100_A7FNG6
UniRef90: UniRef90_A1JIJ7
UniRef50: UniRef50_A9IZD0
UniParc: UPI00000CDA75
EMBL: AL590842
EMBL: AE009952
EMBL: AE017042
EMBL-CDS: CAL22315.1
EMBL-CDS: AAM84091.1
EMBL-CDS: AAS63261.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
RefSeq_NT: NC_003143.1
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
GenomeReviews: AL590842_GR
KEGG: ype:YPO3728
KEGG: ypk:y0502
KEGG: ypm:YP_3091
HOGENOM: HBG498048
OMA: ASDGFFP
ProtClustDB: PRK00881
BioCyc:
Taxonomy ID 229193
Gene Starting Position 3441736
Gene Ending Position 3443370
Gene Strand (Orientation) +
Protein Name bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
DNA Sequence 
>gi|45439865:3441736-3443370 Yersinia pestis biovar Microtus str. 91001 chromosome, complete genome
ATTGATAATGAAGAAAACTGCGACTCCAAATCCAAGGGATAAAACCATGCAACAACGCCGTCCAATCCGC
CGTGCTCTACTCAGTGTGTCTGACAAAGCAGGTATCATCGAATTCGCCCAAGCACTTTCTCAACGCGGTA
TCGAGTTACTTTCCACCGGTGGGACTGCCCGCCTGCTGGCTGATGCTGGTTTACCCGTTACCGAAGTGTC
TGACTACACCGGTTTCCCGGAAATGATGGATGGACGTGTGAAGACTTTGCATCCAAAGGTGCATGGTGGG
ATTTTAGGTCGTCGTGGTCAGGATGATGGCATCATGGCTCAACATGGCATTCAGCCCATTGATATTGTCG
TCGTTAATTTATATCCCTTCGCCCAGACGGTTGCCCGCCCGGATTGCTCGTTGGAAGATGCGGTTGAGAA
TATTGATATTGGTGGCCCAACCATGGTTCGCTCTGCGGCCAAGAACCATAAAGATGTCGCCATCGTGGTG
AAGAGTAGCGACTACCCCGCCATTATTACTGAGCTTGATAATAATGATGGTTCGTTGACTTACCCCACCC
GCTTCAATCTGGCCATTAAAGCTTTCGAACACACCGCCGCCTACGACAGCATGATCGCCAACTACTTCGG
CACACTGGTGCCACCTTATCATGGTGATACGGAACAGCCTTCCGGCCACTTCCCTCGCACCCTAAATCTT
AACTATATAAAGAAGCAGGATATGCGTTACGGTGAAAACAGCCACCAGCAAGCTGCCTTCTATATAGAAG
AAGATGTCAAAGAGGCATCCGTTGCCACTGCCCAGCAATTACAAGGGAAAGCCCTCTCTTATAACAATAT
TGCGGATACCGATGCCGCGCTGGAATGCGTGAAAGAGTTCAGTGAACCAGCCTGTGTGATCGTTAAACAT
GCCAACCCATGCGGTGTGGCTATCGGTGATTCTATTCTTGCCGCTTATGAACGTGCCTATCAAACCGATC
CAACCTCAGCTTTCGGTGGCATCATCGCCTTTAACCGTGAATTGGATGCAGCAACGGCCAGCGCGATCAT
CAGCCGCCAGTTTGTCGAAGTGATCATTGCGCCAACAGTCAGCTCTGATGCATTGGCATTGCTTGCAGCT
AAACAAAATGTCCGAGTCCTGACTTGTGGCCAGTGGCAAGCACGTTCAGCAGGTTTAGATTTCAAACGTG
TTAATGGGGGTTTGCTGGTACAAGAACGCGATTTAGGTATGGTGACGGCGGCCGACCTTCGCGTGGTTTC
CAAGCGTCAGCCTACCGAACAGGAACTGCGTGATGCGCTGTTCTGCTGGAAAGTGGCTAAGTTTGTTAAA
TCCAATGCGATTGTCTATGCCCGCGATAACATGACAATCGGTATAGGTGCCGGCCAAATGAGCCGCGTGT
ACTCTGCGAAAATAGCCGGTATCAAGGCCGCAGATGAAGGGCTGGAAGTGGCTGGCTCAGCCATGGCCTC
TGATGCCTTCTTCCCGTTCCGTGATGGTATTGATGCCGCCGCGGCTGTGGGCATTACTTGTGTCATCCAA
CCGGGCGGCTCAATTCGTGATGATGAAGTCATCGCGGCTGCTGATGAACACAGTATTGCCATGATCTTCA
CCGACATGCGCCATTTCCGTCATTA
Protein Sequence 
>gi|45442845|ref|NP_994384.1| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Yersinia pestis biovar Microtus str. 91001] MIMKKTATPNPRDKTMQQRRPIRRALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDGIMAQHGIQPIDIVVVNLYPFAQTVARPDCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYPAIITELDNNDGSLTYPTRFNLAIKAFEHTAAYDSMIANYFGTLVPPYHGDTEQPSGHFPRTLNLNYIKKQDMRYGENSHQQAAFYIEEDVKEASVATAQQLQGKALSYNNIADTDAALECVKEFSEPACVIVKHANPCGVAIGDSILAAYERAYQTDPTSAFGGIIAFNRELDAATASAIISRQFVEVIIAPTVSSDALALLAAKQNVRVLTCGQWQARSAGLDFKRVNGGLLVQERDLGMVTAADLRVVSKRQPTEQELRDALFCWKVAKFVKSNAIVYARDNMTIGIGAGQMSRVYSAKIAGIKAADEGLEVAGSAMASDAFFPFRDGIDAAAAVGITCVIQPGGSIRDDEVIAAADEHSIAMIFTDMRHFRH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purH mutant is attenuated in mice (Flashner et al., 2004).
COG COG0138F, under F: Nucleotide transport and metabolism
References
Flashner et al., 2004: Flashner Y, Mamroud E, Tidhar A, Ber R, Aftalion M, Gur D, Lazar S, Zvi A, Bino T, Ariel N, Velan B, Shafferman A, Cohen S. Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates. Infection and immunity. 2004; 72(2); 908-915. [PubMed: 14742535].