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yopT from Yersinia pestis KIM 10

Victor ID 2533
Gene Name yopT from Yersinia pestis KIM 10
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
NCBI Gene ID 2700511
NCBI Protein GI 31795299
Locus Tag YKCD1p48
Protein Accession NP_857758.1
Other Database IDs UniProtKB-ID: YOPT_YERPE
UniRef100: UniRef100_O68703
UniRef90: UniRef90_A1JU65
UniRef50: UniRef50_A1JU65
UniParc: UPI00000D1251
EMBL: AF074612
EMBL: AF053946
EMBL: AL117189
EMBL: AE017043
EMBL-CDS: AAC69833.1
EMBL-CDS: AAC62582.1
EMBL-CDS: CAB54897.1
EMBL-CDS: AAS58582.1
RefSeq_NT: NC_003131.1
RefSeq_NT: NC_004836.1
RefSeq_NT: NC_004839.1
RefSeq_NT: NC_005813.1
MEROPS: C58.001
GenomeReviews: AE017043_GR
GenomeReviews: AL117189_GR
KEGG: ype:YPCD1.20
KEGG: ypm:YP_pCD67
HOGENOM: HBG624384
OMA: PISS
Taxonomy ID 187410
Plasmid No pCD1
Gene Starting Position 34859
Gene Ending Position 35827
Gene Strand (Orientation) -
Protein Name secreted effector protein
DNA Sequence 
>gi|31795262:34859-35827 Yersinia pestis KIM plasmid pCD1, complete sequence
ATTAAACCTCCTTGGAGTCAAATGTTAACACTCTAAAACGCTGCCCCACCCCCAGAGGATAATGATACAT
AGAATTACCCCAGAATGAGTTAGTAAACCATTTGCGGAACTTTTCCTTATCAGAAAAGTGGAATTCACCG
AAATTGGGATCGAAGAAAGTAACACCACTCTTTTCGTTGACATACGCCGCTATGGCGTGGGCTGACATTT
GGCCTGAGAGATGTATTTTTTTATAACCGTAACCTATCCCATGAGTATCAAGGATAGCGTTTAATAATTG
ATCCAGCCCTTCTGATTCCGTCGTACCAGTAACATCAACTGGACGCAGTAAGCAATGCCGTTCAATCATA
CGTTCTGATATGCCATTTTTCTTGAACCAATCTAGTGTTACCTCATCTTGATCAACGTCTGCTTTACAAC
CATCTATTTGCAACTGTTTAATTGAGTAAAGTGTATCGATCTGGAATTTCCCCTTACGCCCGCCAACATA
GAGCTGGTCAAATAAGCTTTGGCCTTGTGCATGGCTCCTGATCCAATGTGCACATAAAGCCTCACAGACA
CCGCTAGCAGTGTCTGAATGTTTTATTATTTTATGAAGAAAAGCCCCTTTGGTCTGAGCAAACTTGAAAT
TGATGTTACCTCCGTAATTTGCAACAGACTCTCTCACCGCGGGCACACGAGTGCTGAGTACAAAATGTAT
CATGCGATACATAATCATACTGAAGGTAAAGCTGCTGCGTTGGTTAGCTTTGCCGTCGCTGGTCAACTTT
CTATCCAGCATAGAACGGCCTGACTGGTTATGTTTTATGGTGGCTGATAACTTTTTCTGCAGGTTTGAGT
GTGACAGTGCTGTTTCCACTTTCACTCGGTGTGCGCCAATCACCCCTTCGGTGAGGGTAGCTGATTGAAG
GTTTTCACCGGCAGAATAATTCGATAGTTGAATATGGTAGTGTCCGTGAATACTGTTCA
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT (Iriarte and Cornelis, 1998).
References
Iriarte and Cornelis, 1998: Iriarte M, Cornelis GR. YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells. Molecular microbiology. 1998; 29(3); 915-929. [PubMed: 9723929].