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yopH from Yersinia pestis biovar Microtus str. 91001

Victor ID 2501
Gene Name yopH from Yersinia pestis biovar Microtus str. 91001
Sequence Strain (Species/Organism) Yersinia pestis biovar Microtus str. 91001
NCBI Gene ID 2767526
NCBI Protein GI 45478518
Locus Tag YP_pCD17
Protein Accession NP_995345.1
Other Database IDs UniProtKB-ID: Q7ARH8_YERPE
UniRef100: UniRef100_P08538
UniRef90: UniRef90_P08538
UniRef50: UniRef50_P15273
UniParc: UPI00000D1266
EMBL: AE017043
EMBL: AL117189
EMBL-CDS: AAS58536.1
EMBL-CDS: CAB54944.1
RefSeq_NT: NC_003131.1
RefSeq_NT: NC_005813.1
PDB: 1QZ0
GenomeReviews: AE017043_GR
GenomeReviews: AL117189_GR
KEGG: ype:YPCD1.67c
KEGG: ypm:YP_pCD17
HOGENOM: HBG299062
OMA: SAHEIAN
ProtClustDB: CLSK862151
BioCyc: YPES214092:YPCD1.67C-MONOMER
Taxonomy ID 229193
Plasmid No pCD1
Gene Starting Position 12346
Gene Ending Position 13752
Gene Strand (Orientation) +
Protein Name putative protein-tyrosine phosphatase Yop effector YopH
DNA Sequence 
>gi|45478502:12346-13752 Yersinia pestis biovar Microtus str. 91001 plasmid pCD1, complete sequence
CATGAACTTATCATTAAGCGATCTTCATCGTCAGGTATCTCGATTGGTGCAGCAAGAGAGCGGTGATTGT
ACCGGGAAATTAAGAGGTAACGTTGCTGCCAATAAAGAAACTACCTTTCAAGGTTTGACCATAGCCAGTG
GAGCCAGAGAGTCAGAAAAAGTATTTGCTCAAACTGTACTAAGCCACGTAGCAAATGTTGTTCTAACTCA
AGAAGATACCGCTAAGCTATTGCAAAGTACGGTAAAGCATAATTTGAATAATTATGACTTAAGAAGTGTC
GGCAATGGTAATAGTGTACTTGTCAGTTTACGTAGTGACCAAATGACACTACAAGACGCCAAAGTGCTGT
TGGAGGCCGCATTGCGACAAGAGTCGGGAGCGAGGGGGCATGTATCATCTCATTCACATTCAGCCCTTCA
CGCACCGGGAACCCCGGTGCGTGAAGGACTGCGTTCACATCTAGACCCCAGAACTCCACCGTTGCCACCG
CGTGAACGACCACACACTTCTGGCCATCACGGGGCTGGCGAAGCCAGAGCCACCGCACCAAGCACTGTTT
CTCCTTATGGCCCAGAAGCGCGCGCAGAACTCAGCAGCCGCCTCACCACATTGCGCAATACGCTGGCGCC
AGCAACGAATGATCCGCGTTACTTACAAGCCTGCGGCGGTGAAAAGCTAAACCGATTTAGAGATATTCAA
TGCTGTCGGCAAACCGCAGTACGCGCCGATCTTAATGCCAATTACATCCAGGTCGGTAACACTCGTACCA
TAGCGTGCCAGTATCCGCTACAATCTCAACTTGAAAGCCATTTCCGTATGCTGGCAGAAAACCGAACGCC
AGTGTTGGCTGTTTTAGCGTCCAGTTCTGAGATAGCCAATCAAAGATTCGGTATGCCAGATTATTTCCGC
CAGAGTGGTACCTATGGCAGTATCACTGTAGAGTCTAAAATGACTCAGCAAGTTGGTCTCGGTGACGGGA
TTATGGCAGATATGTATACTTTAACGATTCGTGAAGCGGGTCAAAAAACAATCTCTGTTCCTGTGGTTCA
TGTTGGCAATTGGCCCGATCAGACCGCAGTCAGCTCTGAAGTTACCAAGGCACTCGCTTCACTGGTAGAT
CAAACAGCAGAAACAAAACGCAATATGTATGAAAGCAAAGGAAGTTCAGCGGTAGGAGATGACTCCAAAT
TACGGCCGGTAATACATTGCCGTGCGGGTGTTGGCCGTACTGCGCAACTGATTGGCGCAATGTGCATGAA
TGATAGTCGTAATAGTCAGTTAAGCGTAGAAGATATGGTCAGCCAAATGCGAGTACAAAGAAATGGTATT
ATGGTACAAAAAGATGAGCAACTTGATGTTCTGATTAAGTTGGCTGAAGGACAAGGGCGACCATTATTAA
ATAGCTA
Protein Sequence 
>gi|45478518|ref|NP_995345.1| putative protein-tyrosine phosphatase Yop effector YopH [Yersinia pestis biovar Microtus str. 91001] MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANVVLTQEDTAKLLQSTVKHNLNNYDLRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSALHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVGDDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis (Andersson et al., 1996).
COG COG5599T, under T: Signal transduction mechanisms
References
Andersson et al., 1996: Andersson K, Carballeira N, Magnusson KE, Persson C, Stendahl O, Wolf-Watz H, Fällman M. YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis. Molecular microbiology. 1996; 20(5); 1057-1069. [PubMed: 8809758].