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yopD from Yersinia pestis KIM 10

Victor ID 2516
Gene Name yopD from Yersinia pestis KIM 10
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
NCBI Gene ID 1149313
NCBI Protein GI 31795494
Locus Tag Y0053
Protein Accession NP_857949.1
Other Database IDs UniProtKB-ID: O68699_YERPE
UniRef100: UniRef100_Q06131
UniRef90: UniRef90_Q06131
UniRef50: UniRef50_Q06131
UniParc: UPI00000D606B
EMBL: AF053946
EMBL: AF074612
EMBL-CDS: AAC62577.1
EMBL-CDS: AAC69802.1
RefSeq_NT: NC_004836.1
RefSeq_NT: NC_004839.1
HSSP: Q06131
OMA: MAVVSGV
ProtClustDB: CLSK862121
Taxonomy ID 187410
Plasmid No pCD1
Gene Starting Position 40619
Gene Ending Position 41539
Gene Strand (Orientation) +
Protein Name secreted effector protein
DNA Sequence 
>gi|31795449:40619-41539 Yersinia pestis KIM plasmid pCD1, complete sequence
CATGACAATAAATATCAAGACAGACAGCCCAATTATCACGACCGGTTCACAGCTTGATGCCATCACTACA
GAGACAGTCAAGCAAAGCGGTGAGATTAAAAAAACAGAAGACACCCGTCATGAAGCACAAGCAATAAAGA
GTAGCGAGGCAAGCTTATCTCGGTCACAGGTGCCAGAATTGATCAAACCGAGCCAGGGAATCAATGTTGC
ATTACTGAGTAAAAGCCAGGGTGATCTTAATGGTACTTTAAGTATCTTGTTGTTGCTGTTGGAACTGGCA
CGTAAAGCGCGAGAAATGGGTTTGCAACAAAGGGATATAGAAAATAAAGCTACTATTACTGCCCAAAAGG
AGCAGGTAGCGGAGATGGTCAGCGGTGCAAAACTGATGATCGCCATGGCGGTGGTGTCTGGCATCATGGC
TGCTACTTCTACGGTTGCTAGTGCTTTTTCTATAGCGAAAGAGGTGAAAATAGTTAAACAGGAACAAATT
CTAAACAGTAATATTGCTGGCCGCGAACAACTTATTGATACAAAAATGCAGCAAATGAGTAACATTGGTG
ATAAAGCGGTAAGCAGAGAGGATATCGGGAGAATATGGAAACCAGAGCAGGTAGCGGATCAAAATAAGCT
GGCATTATTGGATAAAGAATTCAGAATGACCGACTCAAAAGCCAATGCGTTTAATGCCGCAACGCAGCCG
TTAGGACAAATGGCAAACAGTGCGATTCAAGTTCATCAAGGGTATTCTCAAGCCGAGGTCAAAGAGAAAG
AAGTCAATGCAAGTATTGCTGCCAACGAGAAGCAAAAAGCCGAAGAGGCGATGAACTATAATGATAACTT
TATGAAAGATGTCCTGCGCTTGATTGAACAATATGTTAGCAGTCATACTCACGCCATGAAAGCCGCTTTT
GGTGTTGTCTG
Protein Sequence 
>gi|31795494|ref|NP_857949.1| Yop targeting negative regulator [Yersinia pestis] MTINIKTDSPIITTGSQLDAITTETVKQSGEIKKTEDTRHEAQAIKSSEASLSRSQVPELIKPSQGINVALLSKSQGDLNGTLSILLLLLELARKAREMGLQQRDIENKATITAQKEQVAEMVSGAKLMIAMAVVSGIMAATSTVASAFSIAKEVKIVKQEQILNSNIAGREQLIDTKMQQMSNIGDKAVSREDIGRIWKPEQVADQNKLALLDKEFRMTDSKANAFNAATQPLGQMANSAIQVHQGYSQAEVKEKEVNASIAANEKQKAEEAMNYNDNFMKDVLRLIEQYVSSHTHAMKAAFGVV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells (Rosqvist et al., 1991).
References
Rosqvist et al., 1991: Rosqvist R, Forsberg A, Wolf-Watz H. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption. Infection and immunity. 1991; 59(12); 4562-4569. [PubMed: 1937815].