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yopB from Yersinia pestis KIM 10

Victor ID 2515
Gene Name yopB from Yersinia pestis KIM 10
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
NCBI Gene ID 1149312
NCBI Protein GI 31795493
Locus Tag Y0052
Protein Accession NP_857948.1
Other Database IDs UniProtKB-ID: O68698_YERPE
UniRef100: UniRef100_O68698
UniRef90: UniRef90_Q06114
UniRef50: UniRef50_Q06114
UniParc: UPI00000D607E
EMBL: AF053946
EMBL: AF074612
EMBL-CDS: AAC62576.1
EMBL-CDS: AAC69801.1
RefSeq_NT: NC_004836.1
RefSeq_NT: NC_004839.1
OMA: IFGWISA
ProtClustDB: CLSK862122
Taxonomy ID 187410
Plasmid No pCD1
Gene Starting Position 39395
Gene Ending Position 40600
Gene Strand (Orientation) +
Protein Name secreted effector protein
DNA Sequence 
>gi|31795449:39395-40600 Yersinia pestis KIM plasmid pCD1, complete sequence
CATGAGTGCGTTGATAACCCATGACCGCTCAACGCCAGTAACTGGAAGTCTACTTCCCTACGTCGAGACA
CCAGCGCCCGCCCCCCTTCAGACCCAACAAGTCGCGGGAGAACTGAAGGATAAAAATGGCGGGGTGAGTT
CTCAGGGCGTACAGCTCCCTGCACCACTAGCAGTGGTTGCCAGCCAAGTTACTGAAGGACAACAGCAAGA
AGTCACTAAATTATTGGAGTCGGTCACCCGCGGCGCGGCAGGATCTCAACTGATATCAAATTATGTTTCA
GTGCTAACGAAGTTTACGCTTGCTTCACCTGATACATTTGAGATTGAGTTAGGTAAGCTAGTTTCTAATT
TAGAAGAAGTACGCAAAGACATAAAAATCGCTGATATTCAGCGTCTTCATGAACAAAACATGAAGAAAAT
TGAAGAGAATCAAGAGAAAATCAAAGAAACAGAAGAGAATGCCAAGCAAGTCAAGAAATCCGGCATCGCA
TCAAAGATTTTTGGCTGGCTCAGCGCCATAGCCTCAGTGATTGTCGGTGCCATCATGGTGGCCTCAGGGG
TAGGAGCCGTTGCCGGTGCAATGATGGTTGCCTCAGGCGTAATTGGGATGGCGAATATGGCAGTGAAACA
AGCGGCGGAAGATGGCCTGATATCCCAAGAGGCAATGAAAATATTAGGGCCGATACTCACTGCGATTGAA
GTCGCATTGACTGTAGTTTCAACCGTAATGACCTTTGGCGGTTCGGCACTAAAATGCCTGGCTAATATTG
GCGCAAAACTCGGTGCTAACACCGCAAGTCTTGTGGCTAAAGGAGCCGAGTTTTCGGCCAAAGTTGCCCA
AATTTCGACAGGCATATCAAACACTGTCGGGAGTGCAGTGACTAAATTAGGGGGCAGTTTTGCTGGTTTA
ACAATGAGCCATGCAATCCGTACAGGATCACAGGCAACACAAGTCGCCGTTGGTGTGGGCAGCGGAATAA
CTCAGACCATCAATAATAAAAAGCAAGCTGATTTACAACATAATAACGCTGATTTGGCCTTGAACAAGGC
AGACATGGCAGCGTTACAAAGTATTATTGACCGACTCAAAGAAGAGTTATCCCATTTGTCAGAGTCACAT
CAACAAGTGATGGAACTGATTTTCCAGATGATTAATGCAAAAGGTGACATGCTGCATAATTTGGCCGGCA
GACCCCATACTGTTTA
Protein Sequence 
>gi|31795493|ref|NP_857948.1| Yop targeting protein [Yersinia pestis] MSALITHDRSTPVTGSLLPYVETPAPAPLQTQQVAGELKDKNGGVSSQGVQLPAPLAVVASQVTEGQQQEVTKLLESVTRGAAGSQLISNYVSVLTKFTLASPDTFEIELGKLVSNLEEVRKDIKIADIQRLHEQNMKKIEENQEKIKETEENAKQVKKSGIASKIFGWLSAIASVIVGAIMVASGVGAVAGAMMVASGVIGMANMAVKQAAEDGLISQEAMKILGPILTAIEVALTVVSTVMTFGGSALKCLANIGAKLGANTASLVAKGAEFSAKVAQISTGISNTVGSAVTKLGGSFAGLTMSHAIRTGSQATQVAVGVGSGITQTINNKKQADLQHNNADLALNKADMAALQSIIDRLKEELSHLSESHQQVMELIFQMINAKGDMLHNLAGRPHTV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells (HÃ¥kansson et al., 1996).
References
Håkansson et al., 1996: Håkansson S, Schesser K, Persson C, Galyov EE, Rosqvist R, Homblé F, Wolf-Watz H. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity. The EMBO journal. 1996; 15(21); 5812-5823. [PubMed: 8918459].