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yopT from Yersinia pestis CA88-4125

Victor ID 2480
Gene Name yopT from Yersinia pestis CA88-4125
Sequence Strain (Species/Organism) Yersinia pestis CA88-4125
NCBI Gene ID 5236062
NCBI Protein GI 149192716
Locus Tag YPE_4232
Protein Accession YP_001293948.1
Other Database IDs UniProtKB-ID: A6M3U9_YERPE
UniRef100: UniRef100_O68703
UniRef90: UniRef90_A1JU65
UniRef50: UniRef50_A1JU65
UniParc: UPI00000D1251
EMBL: CP000722
EMBL-CDS: ABR14864.1
RefSeq_NT: NC_009595.1
OMA: PISSINH
ProtClustDB: CLSK862118
Taxonomy ID 412420
Plasmid No pCD1
Gene Starting Position 63375
Gene Ending Position 64343
Gene Strand (Orientation) -
Protein Name Translocated cysteine protease/Rho GTPase toxin
DNA Sequence 
>gi|149192647:63375-64343 Yersinia pestis CA88-4125 plasmid pCD1, complete sequence
ATTAAACCTCCTTGGAGTCAAATGTTAACACTCTAAAACGCTGCCCCACCCCCAGAGGATAATGATACAT
AGAATTACCCCAGAATGAGTTAGTAAACCATTTGCGGAACTTTTCCTTATCAGAAAAGTGGAATTCACCG
AAATTGGGATCGAAGAAAGTAACACCACTCTTTTCGTTGACATACGCCGCTATGGCGTGGGCTGACATTT
GGCCTGAGAGATGTATTTTTTTATAACCGTAACCTATCCCATGAGTATCAAGGATAGCGTTTAATAATTG
ATCCAGCCCTTCTGATTCCGTCGTACCAGTAACATCAACTGGACGCAGTAAGCAATGCCGTTCAATCATA
CGTTCTGATATGCCATTTTTCTTGAACCAATCTAGTGTTACCTCATCTTGATCAACGTCTGCTTTACAAC
CATCTATTTGCAACTGTTTAATTGAGTAAAGTGTATCGATCTGGAATTTCCCCTTACGCCCGCCAACATA
GAGCTGGTCAAATAAGCTTTGGCCTTGTGCATGGCTCCTGATCCAATGTGCACATAAAGCCTCACAGACA
CCGCTAGCAGTGTCTGAATGTTTTATTATTTTATGAAGAAAAGCCCCTTTGGTCTGAGCAAACTTGAAAT
TGATGTTACCTCCGTAATTTGCAACAGACTCTCTCACCGCGGGCACACGAGTGCTGAGTACAAAATGTAT
CATGCGATACATAATCATACTGAAGGTAAAGCTGCTGCGTTGGTTAGCTTTGCCGTCGCTGGTCAACTTT
CTATCCAGCATAGAACGGCCTGACTGGTTATGTTTTATGGTGGCTGATAACTTTTTCTGCAGGTTTGAGT
GTGACAGTGCTGTTTCCACTTTCACTCGGTGTGCGCCAATCACCCCTTCGGTGAGGGTAGCTGATTGAAG
GTTTTCACCGGCAGAATAATTCGATAGTTGAATATGGTAGTGTCCGTGAATACTGTTCA
Protein Sequence 
>gi|149192716|ref|YP_001293948.1| translocated cysteine protease/Rho GTPase toxin [Yersinia pestis CA88-4125] MNSIHGHYHIQLSNYSAGENLQSATLTEGVIGAHRVKVETALSHSNLQKKLSATIKHNQSGRSMLDRKLTSDGKANQRSSFTFSMIMYRMIHFVLSTRVPAVRESVANYGGNINFKFAQTKGAFLHKIIKHSDTASGVCEALCAHWIRSHAQGQSLFDQLYVGGRKGKFQIDTLYSIKQLQIDGCKADVDQDEVTLDWFKKNGISERMIERHCLLRPVDVTGTTESEGLDQLLNAILDTHGIGYGYKKIHLSGQMSAHAIAAYVNEKSGVTFFDPNFGEFHFSDKEKFRKWFTNSFWGNSMYHYPLGVGQRFRVLTFDSKEV
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT (Iriarte and Cornelis, 1998).
References
Iriarte and Cornelis, 1998: Iriarte M, Cornelis GR. YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells. Molecular microbiology. 1998; 29(3); 915-929. [PubMed: 9723929].