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YPO3973

Victor ID 1175
Gene Name YPO3973
Sequence Strain (Species/Organism) Yersinia pestis CO92
NCBI Gene ID 1176811
NCBI Protein GI 16124100
Locus Tag YPO3973
Protein Accession NP_407413.1
Other Database IDs UniProtKB-ID: Q7CG03_YERPE
UniRef100: UniRef100_D1Q1W2
UniRef90: UniRef90_D1Q1W2
UniRef50: UniRef50_B2K6K5
UniParc: UPI00000DCB51
EMBL: AE009952
EMBL: AE017042
EMBL: AL590842
EMBL-CDS: AAM87402.1
EMBL-CDS: AAS63500.1
EMBL-CDS: CAL22553.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
RefSeq_NT: NC_003143.1
HSSP: O69771
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
GenomeReviews: AL590842_GR
KEGG: ype:YPO3973
KEGG: ypk:y3857
KEGG: ypm:YP_3335
HOGENOM: HBG598843
OMA: TYAEDTR
ProtClustDB: CL
Taxonomy ID 214092
Gene Starting Position 4472442
Gene Ending Position 4473779
Gene Strand (Orientation) +
Protein Name metalloprotease
DNA Sequence 
>gi|16120353:4472442-4473779 Yersinia pestis CO92 chromosome, complete genome
GGTGATGTTTATGAGTTACTCCAGGGAATACAGCAATACTATAATTAAAAATGAACAGGTCATGCGTAGA
GGCATTCATTATAAGAATGAAGTTAAAGGTGTTATAGCACCACAAATATCTAGCCGTCAGTCATGGAAAG
AAAACACCATTCATAATAAAAATACAAACCTGACATATTCATTTAGTCGAGCCTATACATTATGGGATTA
TGATCGAACATTCCAACAGAACGCTTACATCTCATTATTTAATCCAGCCCAAATCCATCAGGCAAAAATC
GCGATGCAATCTTGGGCTGATGTAGCCAACATCTCCTTCACCGAAGCATCAGCAGACTCCTCCGCCAATA
TTCTATTTTTAAATTTTCAGCGCCCAAGTAATGTGGCAGGTTATGCCTATTATCCTAATCCAGGTAGCTT
CAGCCCAATATGGATTAATTACAGTTTCAGCGATAACCAACATCCCAGCAGATTAAATGATGGTGGCGGA
GTATTAACACATGAGATCGGCCATGCTCTGGGGTTGGGTCATTCTCATGCCCCCCATGGCTATACACAGC
AAATGAGTGTAATGAGCTATTTATCCGAACAGGGTTCAGGTGCAAATTATGGCCAACATTACTTATCCAC
ACCACAAATGTACGATATCGCCGCAATCCAGTATCTGTATGGGGCCAATCTACACACCCGCACCGGTGAT
ACCGTTTATGGCTTCAACTCGACGAGTTATAGAGATCATTTCACCGCCACCCACGCCAGTGATGCGTTGA
TTTTCTGTGTCTGGGATGCTGGCGGCAATGATACTTTTGACTTCTCTGGCTATAAGCAAAATCAAATGAT
TAATCTTAACGAACTCTGTTTTTCTGATGTTGGTGGACTAAAAGGAAATGTGTCTATTGCAGCGGATGTT
ACGATTGAAAATGCCATCGGCGGCAGTGGCCATGATGATATTATCGGCAATCACACCAATAATATTTTGA
CCGGTAACGGCGGATCTGATCAACTTTGGGGTAACGGGGGCAATAATACTTTCCGCTATGCCAGTGCCAG
AGATTCAATGACCACCTCGCCCGATACTATTCATGATTTTAAATCAGGCCGTGACAAGATAGATTTGTCG
CAATTAATGCCCTCAACCGACCGTGTTATTTTTGTCGATAGATTAAGTTTTAACGGTCAAACAGAGATGG
GGCAGCAATATAATGAAGTGGCGGACATAACTTATCTTATGATTGATTTTGACGCTCAAGTCAGCGAGTG
CGATATGATGATTAAATTTACCGGCAGGCACCATTTCACCGCCAATGACTTTATTTTAAGTACGTCACTG
ACGGCATA
Protein Sequence 
>gi|218930968|ref|YP_002348843.1| metalloprotease [Yersinia pestis CO92] MMFMSYSREYSNTIIKNEQVMRRGIHYKNEVKGVIAPQISSRQSWKENTIHNKNTNLTYSFSRAYTLWDYDRTFQQNAYISLFNPAQIHQAKIAMQSWADVANISFTEASADSSANILFLNFQRPSNVAGYAYYPNPGSFSPIWINYSFSDNQHPSRLNDGGGVLTHEIGHALGLGHSHAPHGYTQQMSVMSYLSEQGSGANYGQHYLSTPQMYDIAAIQYLYGANLHTRTGDTVYGFNSTSYRDHFTATHASDALIFCVWDAGGNDTFDFSGYKQNQMINLNELCFSDVGGLKGNVSIAADVTIENAIGGSGHDDIIGNHTNNILTGNGGSDQLWGNGGNNTFRYASARDSMTTSPDTIHDFKSGRDKIDLSQLMPSTDRVIFVDRLSFNGQTEMGQQYNEVADITYLMIDFDAQVSECDMMIKFTGRHHFTANDFILSTSLTA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: YPO3973 mutant is attenuated in mice (Flashner et al., 2004).
References
Flashner et al., 2004: Flashner Y, Mamroud E, Tidhar A, Ber R, Aftalion M, Gur D, Lazar S, Zvi A, Bino T, Ariel N, Velan B, Shafferman A, Cohen S. Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates. Infection and immunity. 2004; 72(2); 908-915. [PubMed: 14742535].