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ypkA from Yersinia pestis CA88-4125

Victor ID 2489
Gene Name ypkA from Yersinia pestis CA88-4125
Sequence Strain (Species/Organism) Yersinia pestis CA88-4125
NCBI Gene ID 5236112
NCBI Protein GI 149192671
Locus Tag YPE_4182
Protein Accession YP_001293903.1
Other Database IDs UniProtKB-ID: A6M3Q4_YERPE
UniRef100: UniRef100_Q9RI12
UniRef90: UniRef90_Q9RI12
UniRef50: UniRef50_Q9RI12
UniParc: UPI00000D1292
EMBL: CP000722
EMBL-CDS: ABR14819.1
RefSeq_NT: NC_009595.1
OMA: VGELNIE
ProtClustDB: CLSK862113
Taxonomy ID 412420
Plasmid No pCD1
Gene Starting Position 23282
Gene Ending Position 25480
Gene Strand (Orientation) +
Protein Name Protein kinase, host Rho GTPase toxin
DNA Sequence 
>gi|149192647:23282-25480 Yersinia pestis CA88-4125 plasmid pCD1, complete sequence
CATGAAAAGCGTGAAAATCATGGGAACTATGCCACCGTCGATCTCCCTCGCCAAAGCTCATGAGCGCATC
AGCCAACATTGGCAAAATCCTGTCGGTGAGCTCAATATCGGAGGAAAACGGTATAGAATTATCGATAATC
AAGTGTTGCGCTTGAACCCCCACAGTGGTTTTTCTCTCTTTCGAGAAGGGGTTGGTAAGATCTTTTCGGG
GAAGATGTTTAACTTTTCAATTGCTCGTAACCTTACTGACACACTCCATGCGGCCCAGAAAACGACTTCG
CAGGAGCTAAGGTCTGATATCCCCAATGCTCTCAGTAATCTCTTTGGAGCCAAGCCACAGACCGAACTGC
CGCTGGGTTGGAAAGGGGAGCCCTTGTCAGGAGCTCCGGATCTTGAAGGGATGCGAGTGGCTGAAACCGA
TAAGTTTGCCGAGGGCGAAAGCCATATTAGTATAATAGAAACTAAGGATAAGCAGCGGTTGGTAGCTAAG
ATTGAACGCTCCATTGCCGAGGGGCATTTGTTCGCAGAACTGGAGGCTTATAAACACATCTATAAAACCG
CGGGCAAACATCCTAATCTTGCCAATGTTCATGGCATGGCTGTGGTGCCATACGGTAACCGTAAGGAGGA
AGCATTGCTGATGGATGAGGTGGATGGTTGGCGTTGTTCTGACACACTAAGAACCCTCGCCGATAGCTGG
AAGCAAGGAAAGATCAATAGTGAAGCCTACTGGGGAACGATCAAGTTTATTGCCCATCGGCTATTAGATG
TAACCAATCACCTTGCCAAGGCAGGGGTAGTACATAACGATATCAAACCCGGTAATGTGGTATTTGACCG
CGCTAGCGGAGAGCCCGTTGTTATTGATCTAGGATTACACTCTCGTTCAGGGGAACAACCTAAGGGGTTT
ACAGAATCCTTCAAAGCGCCGGAGCTTGGAGTAGGAAACCTAGGCGCATCAGAAAAGAGCGATGTTTTTC
TCGTAGTGTCAACCCTTCTACATTGTATCGAAGGTTTTGAGAAAAATCCGGAGATAAAGCCTAATCAAGG
ACTGAGATTCATTACCTCAGAACCAGCGCACGTAATGGATGAGAATGGTTATCCAATCCATCGACCTGGT
ATAGCTGGAGTCGAGACAGCCTATACACGCTTCATCACAGACATCCTTGGCGTTTCCGCTGACTCAAGAC
CTGATTCCAACGAAGCCAGACTCCACGAGTTCTTGAGCGACGGAACTATCGACGAGGAGTCGGCCAAGCA
GATCCTAAAAGATACCCTAACCGGAGAAATGAGCCCATTATCTACTGATGTAAGGCGGATAACACCCAAG
AAGCTTCGGGAGCTATCTGATTTGCTTAGGACGCATTTGAGCAGTGCAGCAACTAAGCAATTGGATATGG
GGGGGGTTTTGTCGGATCTTGATACCATGTTGGTGGCACTCGACAAGGCCGAACGCGAGGGGGGAGTAGA
CAAGGATCAGTTGAAGAGTTTTAACAGTTTGATTCTGAAGACTTACAGAGTGATTGAAGACTATGTCAAA
GGCAGAGAAGGGGATACCAAGAATTCCAGTACGGAAGTATCCCCCTATCATCGCAGTAACTTTATGCTAT
CGATCGTCGAACCTTCACTGCAGAGGATCCAGAAGCATCTGGACCAGACACACTCTTTTTCTGATATCGG
TTCACTAGTGCGCGCACATAAGCACCTGGAAACGCTTTTAGAGGTCTTAGTCACCTTGTCACAGCAAGGG
CAGCCCGTGTCCTCTGAAACCTACGGCTTCCTGAATCGATTAACTGAGGCTAAGATCACCTTGTCGCAGC
AATTGAATACTCTCCAGCAGCAGCAGGAGAGTGCGAAAGCGCAATTATCTATTCTGATTAATCGTTCAGG
TTCTTGGGCCGATGTTGCTCGTCAGTCCCTGCAGCGTTTTGACAGTACCCGGCCTGTAGTGAAATTCGGC
ACTGAGCAGTATACCGCAATTCACCGTCAGATGATGGCGGCCCATGCAGCTATTACGCTACAGGAGGTAT
CGGAGTTTACTGATGATATGCGAAACTTTACAGTGGACTCTATTCCACTACTGATTCAACTTGGACGAAG
CAGTTTAATGGATGAGCATTTGGTTGAACAGAGAGAAAAGTTGCGAGAGCTGACGACCATCGCCGAGCGA
CTGAACCGGTTGGAGCGGGAATGGATGTG
Protein Sequence 
>gi|149192671|ref|YP_001293903.1| protein kinase, host Rho GTPase toxin [Yersinia pestis CA88-4125] MKSVKIMGTMPPSISLAKAHERISQHWQNPVGELNIGGKRYRIIDNQVLRLNPHSGFSLFREGVGKIFSGKMFNFSIARNLTDTLHAAQKTTSQELRSDIPNALSNLFGAKPQTELPLGWKGEPLSGAPDLEGMRVAETDKFAEGESHISIIETKDKQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRKEEALLMDEVDGWRCSDTLRTLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGVVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTESFKAPELGVGNLGASEKSDVFLVVSTLLHCIEGFEKNPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSDGTIDEESAKQILKDTLTGEMSPLSTDVRRITPKKLRELSDLLRTHLSSAATKQLDMGGVLSDLDTMLVALDKAEREGGVDKDQLKSFNSLILKTYRVIEDYVKGREGDTKNSSTEVSPYHRSNFMLSIVEPSLQRIQKHLDQTHSFSDIGSLVRAHKHLETLLEVLVTLSQQGQPVSSETYGFLNRLTEAKITLSQQLNTLQQQQESAKAQLSILINRSGSWADVARQSLQRFDSTRPVVKFGTEQYTAIHRQMMAAHAAITLQEVSEFTDDMRNFTVDSIPLLIQLGRSSLMDEHLVEQREKLRELTTIAERLNRLEREWM
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice (Galyov et al., 1993).
References
Galyov et al., 1993: Galyov EE, HÃ¥kansson S, Forsberg A, Wolf-Watz H. A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant. Nature. 1993; 361(6414); 730-732. [PubMed: 8441468].