Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

yopB from Yersinia pestis CA88-4125

Victor ID 2483
Gene Name yopB from Yersinia pestis CA88-4125
Sequence Strain (Species/Organism) Yersinia pestis CA88-4125
NCBI Gene ID 5236069
NCBI Protein GI 149192710
Locus Tag YPE_4225
Protein Accession YP_001293942.1
Other Database IDs UniProtKB-ID: A6M3U3_YERPE
UniRef100: UniRef100_O68698
UniRef90: UniRef90_Q06114
UniRef50: UniRef50_Q06114
UniParc: UPI00000D607E
EMBL: CP000722
EMBL-CDS: ABR14858.1
RefSeq_NT: NC_009595.1
OMA: IFGWISA
ProtClustDB: CLSK862122
Taxonomy ID 412420
Plasmid No pCD1
Gene Starting Position 55515
Gene Ending Position 56720
Gene Strand (Orientation) +
Protein Name putative secreted pore/translocation protein
DNA Sequence 
>gi|149192647:55515-56720 Yersinia pestis CA88-4125 plasmid pCD1, complete sequence
CATGAGTGCGTTGATAACCCATGACCGCTCAACGCCAGTAACTGGAAGTCTACTTCCCTACGTCGAGACA
CCAGCGCCCGCCCCCCTTCAGACCCAACAAGTCGCGGGAGAACTGAAGGATAAAAATGGCGGGGTGAGTT
CTCAGGGCGTACAGCTCCCTGCACCACTAGCAGTGGTTGCCAGCCAAGTTACTGAAGGACAACAGCAAGA
AGTCACTAAATTATTGGAGTCGGTCACCCGCGGCGCGGCAGGATCTCAACTGATATCAAATTATGTTTCA
GTGCTAACGAAGTTTACGCTTGCTTCACCTGATACATTTGAGATTGAGTTAGGTAAGCTAGTTTCTAATT
TAGAAGAAGTACGCAAAGACATAAAAATCGCTGATATTCAGCGTCTTCATGAACAAAACATGAAGAAAAT
TGAAGAGAATCAAGAGAAAATCAAAGAAACAGAAGAGAATGCCAAGCAAGTCAAGAAATCCGGCATCGCA
TCAAAGATTTTTGGCTGGCTCAGCGCCATAGCCTCAGTGATTGTCGGTGCCATCATGGTGGCCTCAGGGG
TAGGAGCCGTTGCCGGTGCAATGATGGTTGCCTCAGGCGTAATTGGGATGGCGAATATGGCAGTGAAACA
AGCGGCGGAAGATGGCCTGATATCCCAAGAGGCAATGAAAATATTAGGGCCGATACTCACTGCGATTGAA
GTCGCATTGACTGTAGTTTCAACCGTAATGACCTTTGGCGGTTCGGCACTAAAATGCCTGGCTAATATTG
GCGCAAAACTCGGTGCTAACACCGCAAGTCTTGTGGCTAAAGGAGCCGAGTTTTCGGCCAAAGTTGCCCA
AATTTCGACAGGCATATCAAACACTGTCGGGAGTGCAGTGACTAAATTAGGGGGCAGTTTTGCTGGTTTA
ACAATGAGCCATGCAATCCGTACAGGATCACAGGCAACACAAGTCGCCGTTGGTGTGGGCAGCGGAATAA
CTCAGACCATCAATAATAAAAAGCAAGCTGATTTACAACATAATAACGCTGATTTGGCCTTGAACAAGGC
AGACATGGCAGCGTTACAAAGTATTATTGACCGACTCAAAGAAGAGTTATCCCATTTGTCAGAGTCACAT
CAACAAGTGATGGAACTGATTTTCCAGATGATTAATGCAAAAGGTGACATGCTGCATAATTTGGCCGGCA
GACCCCATACTGTTTA
Protein Sequence 
>gi|149192710|ref|YP_001293942.1| putative secreted pore/translocation protein [Yersinia pestis CA88-4125] MSALITHDRSTPVTGSLLPYVETPAPAPLQTQQVAGELKDKNGGVSSQGVQLPAPLAVVASQVTEGQQQEVTKLLESVTRGAAGSQLISNYVSVLTKFTLASPDTFEIELGKLVSNLEEVRKDIKIADIQRLHEQNMKKIEENQEKIKETEENAKQVKKSGIASKIFGWLSAIASVIVGAIMVASGVGAVAGAMMVASGVIGMANMAVKQAAEDGLISQEAMKILGPILTAIEVALTVVSTVMTFGGSALKCLANIGAKLGANTASLVAKGAEFSAKVAQISTGISNTVGSAVTKLGGSFAGLTMSHAIRTGSQATQVAVGVGSGITQTINNKKQADLQHNNADLALNKADMAALQSIIDRLKEELSHLSESHQQVMELIFQMINAKGDMLHNLAGRPHTV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells (HÃ¥kansson et al., 1996).
References
Håkansson et al., 1996: Håkansson S, Schesser K, Persson C, Galyov EE, Rosqvist R, Homblé F, Wolf-Watz H. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity. The EMBO journal. 1996; 15(21); 5812-5823. [PubMed: 8918459].