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yopT from Yersinia pestis CO92

Victor ID 1120
Gene Name yopT from Yersinia pestis CO92
Sequence Strain (Species/Organism) Yersinia pestis CO92
NCBI Gene ID 1172665
NCBI Protein GI 16082709
Locus Tag YPCD1.20
Protein Accession NP_395155.1
Other Database IDs UniProtKB-ID: YOPT_YERPE
UniRef100: UniRef100_O68703
UniRef90: UniRef90_A1JU65
UniRef50: UniRef50_A1JU65
UniParc: UPI00000D1251
EMBL: AF074612
EMBL: AF053946
EMBL: AL117189
EMBL: AE017043
EMBL-CDS: AAC69833.1
EMBL-CDS: AAC62582.1
EMBL-CDS: CAB54897.1
EMBL-CDS: AAS58582.1
RefSeq_NT: NC_003131.1
RefSeq_NT: NC_004836.1
RefSeq_NT: NC_004839.1
RefSeq_NT: NC_005813.1
MEROPS: C58.001
GenomeReviews: AE017043_GR
GenomeReviews: AL117189_GR
KEGG: ype:YPCD1.20
KEGG: ypm:YP_pCD67
HOGENOM: HBG624384
OMA: PISS
Taxonomy ID 214092
Plasmid No pCD1
Gene Starting Position 12609
Gene Ending Position 13577
Gene Strand (Orientation) +
Protein Name Yop targeted effector
DNA Sequence 
>gi|16082691:12609-13577 Yersinia pestis CO92 plasmid pCD1, complete sequence
GATGAACAGTATTCACGGACACTACCATATTCAACTATCGAATTATTCTGCCGGTGAAAACCTTCAATCA
GCTACCCTCACCGAAGGGGTGATTGGCGCACACCGAGTGAAAGTGGAAACAGCACTGTCACACTCAAACC
TGCAGAAAAAGTTATCAGCCACCATAAAACATAACCAGTCAGGCCGTTCTATGCTGGATAGAAAGTTGAC
CAGCGACGGCAAAGCTAACCAACGCAGCAGCTTTACCTTCAGTATGATTATGTATCGCATGATACATTTT
GTACTCAGCACTCGTGTGCCCGCGGTGAGAGAGTCTGTTGCAAATTACGGAGGTAACATCAATTTCAAGT
TTGCTCAGACCAAAGGGGCTTTTCTTCATAAAATAATAAAACATTCAGACACTGCTAGCGGTGTCTGTGA
GGCTTTATGTGCACATTGGATCAGGAGCCATGCACAAGGCCAAAGCTTATTTGACCAGCTCTATGTTGGC
GGGCGTAAGGGGAAATTCCAGATCGATACACTTTACTCAATTAAACAGTTGCAAATAGATGGTTGTAAAG
CAGACGTTGATCAAGATGAGGTAACACTAGATTGGTTCAAGAAAAATGGCATATCAGAACGTATGATTGA
ACGGCATTGCTTACTGCGTCCAGTTGATGTTACTGGTACGACGGAATCAGAAGGGCTGGATCAATTATTA
AACGCTATCCTTGATACTCATGGGATAGGTTACGGTTATAAAAAAATACATCTCTCAGGCCAAATGTCAG
CCCACGCCATAGCGGCGTATGTCAACGAAAAGAGTGGTGTTACTTTCTTCGATCCCAATTTCGGTGAATT
CCACTTTTCTGATAAGGAAAAGTTCCGCAAATGGTTTACTAACTCATTCTGGGGTAATTCTATGTATCAT
TATCCTCTGGGGGTGGGGCAGCGTTTTAGAGTGTTAACATTTGACTCCAAGGAGGTTTA
Protein Sequence 
>gi|16082709|ref|NP_395155.1| Yop targeted effector [Yersinia pestis CO92] MNSIHGHYHIQLSNYSAGENLQSATLTEGVIGAHRVKVETALSHSNLQKKLSATIKHNQSGRSMLDRKLTSDGKANQRSSFTFSMIMYRMIHFVLSTRVPAVRESVANYGGNINFKFAQTKGAFLHKIIKHSDTASGVCEALCAHWIRSHAQGQSLFDQLYVGGRKGKFQIDTLYSIKQLQIDGCKADVDQDEVTLDWFKKNGISERMIERHCLLRPVDVTGTTESEGLDQLLNAILDTHGIGYGYKKIHLSGQMSAHAIAAYVNEKSGVTFFDPNFGEFHFSDKEKFRKWFTNSFWGNSMYHYPLGVGQRFRVLTFDSKEV
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT (Iriarte and Cornelis, 1998).
References
Iriarte and Cornelis, 1998: Iriarte M, Cornelis GR. YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells. Molecular microbiology. 1998; 29(3); 915-929. [PubMed: 9723929].