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purH from Yersinia pestis CO92

Victor ID 1174
Gene Name purH from Yersinia pestis CO92
Sequence Strain (Species/Organism) Yersinia pestis CO92
NCBI Gene ID 1176554
NCBI Protein GI 16123865
Locus Tag YPO3728
Protein Accession NP_407178.1
Other Database IDs UniProtKB-ID: PUR9_YERPE
UniRef100: UniRef100_A7FNG6
UniRef90: UniRef90_A1JIJ7
UniRef50: UniRef50_A9IZD0
UniParc: UPI00000CDA75
EMBL: AL590842
EMBL: AE009952
EMBL: AE017042
EMBL-CDS: CAL22315.1
EMBL-CDS: AAM84091.1
EMBL-CDS: AAS63261.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
RefSeq_NT: NC_003143.1
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
GenomeReviews: AL590842_GR
KEGG: ype:YPO3728
KEGG: ypk:y0502
KEGG: ypm:YP_3091
HOGENOM: HBG498048
OMA: ASDGFFP
ProtClustDB: PRK00881
BioCyc:
Taxonomy ID 214092
Gene Starting Position 4181117
Gene Ending Position 4182706
Gene Strand (Orientation) +
Protein Name bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
DNA Sequence 
>gi|16120353:4181117-4182706 Yersinia pestis CO92 chromosome, complete genome
CATGCAACAACGCCGTCCAATCCGCCGTGCTCTACTCAGTGTGTCTGACAAAGCAGGTATCATCGAATTC
GCCCAAGCACTTTCTCAACGCGGTATCGAGTTACTTTCCACCGGTGGGACTGCCCGCCTGCTGGCTGATG
CTGGTTTACCCGTTACCGAAGTGTCTGACTACACCGGTTTCCCGGAAATGATGGATGGACGTGTGAAGAC
TTTGCATCCAAAGGTGCATGGTGGGATTTTAGGTCGTCGTGGTCAGGATGATGGCATCATGGCTCAACAT
GGCATTCAGCCCATTGATATTGTCGTCGTTAATTTATATCCCTTCGCCCAGACGGTTGCCCGCCCGGATT
GCTCGTTGGAAGATGCGGTTGAGAATATTGATATTGGTGGCCCAACCATGGTTCGCTCTGCGGCCAAGAA
CCATAAAGATGTCGCCATCGTGGTGAAGAGTAGCGACTACCCCGCCATTATTACTGAGCTTGATAATAAT
GATGGTTCGTTGACTTACCCCACCCGCTTCAATCTGGCCATTAAAGCTTTCGAACACACCGCCGCCTACG
ACAGCATGATCGCCAACTACTTCGGCACACTGGTGCCACCTTATCATGGTGATACGGAACAGCCTTCCGG
CCACTTCCCTCGCACCCTAAATCTTAACTATATAAAGAAGCAGGATATGCGTTACGGTGAAAACAGCCAC
CAGCAAGCTGCCTTCTATATAGAAGAAGATGTCAAAGAGGCATCCGTTGCCACTGCCCAGCAATTACAAG
GGAAAGCCCTCTCTTATAACAATATTGCGGATACCGATGCCGCGCTGGAATGCGTGAAAGAGTTCAGTGA
ACCAGCCTGTGTGATCGTTAAACATGCCAACCCATGCGGTGTGGCTATCGGTGATTCTATTCTTGCCGCT
TATGAACGTGCCTATCAAACCGATCCAACCTCAGCTTTCGGTGGCATCATCGCCTTTAACCGTGAATTGG
ATGCAGCAACGGCCAGCGCGATCATCAGCCGCCAGTTTGTCGAAGTGATCATTGCGCCAACAGTCAGCTC
TGATGCATTGGCATTGCTTGCAGCTAAACAAAATGTCCGAGTCCTGACTTGTGGCCAGTGGCAAGCACGT
TCAGCAGGTTTAGATTTCAAACGTGTTAATGGGGGTTTGCTGGTACAAGAACGCGATTTAGGTATGGTGA
CGGCGGCCGACCTTCGCGTGGTTTCCAAGCGTCAGCCTACCGAACAGGAACTGCGTGATGCGCTGTTCTG
CTGGAAAGTGGCTAAGTTTGTTAAATCCAATGCGATTGTCTATGCCCGCGATAACATGACAATCGGTATA
GGTGCCGGCCAAATGAGCCGCGTGTACTCTGCGAAAATAGCCGGTATCAAGGCCGCAGATGAAGGGCTGG
AAGTGGCTGGCTCAGCCATGGCCTCTGATGCCTTCTTCCCGTTCCGTGATGGTATTGATGCCGCCGCGGC
TGTGGGCATTACTTGTGTCATCCAACCGGGCGGCTCAATTCGTGATGATGAAGTCATCGCGGCTGCTGAT
GAACACAGTATTGCCATGATCTTCACCGACATGCGCCATTTCCGTCATTA
Protein Sequence 
>gi|218930733|ref|YP_002348608.1| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Yersinia pestis CO92] MQQRRPIRRALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDGIMAQHGIQPIDIVVVNLYPFAQTVARPDCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYPAIITELDNNDGSLTYPTRFNLAIKAFEHTAAYDSMIANYFGTLVPPYHGDTEQPSGHFPRTLNLNYIKKQDMRYGENSHQQAAFYIEEDVKEASVATAQQLQGKALSYNNIADTDAALECVKEFSEPACVIVKHANPCGVAIGDSILAAYERAYQTDPTSAFGGIIAFNRELDAATASAIISRQFVEVIIAPTVSSDALALLAAKQNVRVLTCGQWQARSAGLDFKRVNGGLLVQERDLGMVTAADLRVVSKRQPTEQELRDALFCWKVAKFVKSNAIVYARDNMTIGIGAGQMSRVYSAKIAGIKAADEGLEVAGSAMASDAFFPFRDGIDAAAAVGITCVIQPGGSIRDDEVIAAADEHSIAMIFTDMRHFRH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purH mutant is attenuated in mice (Flashner et al., 2004).
References
Flashner et al., 2004: Flashner Y, Mamroud E, Tidhar A, Ber R, Aftalion M, Gur D, Lazar S, Zvi A, Bino T, Ariel N, Velan B, Shafferman A, Cohen S. Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates. Infection and immunity. 2004; 72(2); 908-915. [PubMed: 14742535].