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guaA

Victor ID 1163
Gene Name guaA
Sequence Strain (Species/Organism) Yersinia pestis CO92
NCBI Gene ID 1175694
NCBI Protein GI 16123062
Locus Tag YPO2870
Protein Accession NP_406375.1
Other Database IDs UniProtKB-ID: GUAA_YERPE
UniRef100: UniRef100_Q1C5J6
UniRef90: UniRef90_A7ZPV1
UniRef50: UniRef50_Q3JR65
UniParc: UPI000012BD7B
EMBL: AL590842
EMBL: AE009952
EMBL: AE017042
EMBL-CDS: CAL21481.1
EMBL-CDS: AAM84936.1
EMBL-CDS: AAS62924.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
RefSeq_NT: NC_003143.1
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
GenomeReviews: AL590842_GR
KEGG: ype:YPO2870
KEGG: ypk:y1363
KEGG: ypm:YP_2736
HOGENOM: HBG391775
OMA: MKLVEPL
ProtClustDB: PRK00074
BioCyc:
Taxonomy ID 214092
Gene Starting Position 3203460
Gene Ending Position 3205037
Gene Strand (Orientation) -
Protein Name bifunctional GMP synthase/glutamine amidotransferase protein
DNA Sequence 
>gi|16120353:3203460-3205037 Yersinia pestis CO92 chromosome, complete genome
ATCATTCCCACTCAATCGTTGCAGGTGGCTTGCCGCTGATATCATAAACTACGCGCGAGATACCATTGAC
TTCATTAATGATGCGGTTTGAAACGCGGCCAAGGAAGTCGTATGGCAGATGTGCCCAATGTGCAGTCATG
AAATCAACCGTCTCTACCGCACGCAGAGAGACAACCCAATCATATTTACGGCCATCACCCATCACACCGA
CTGAACGTACTGGCAGGAAGACAGTGAAAGCCTGGCTAACTTTATTGTACAAATCAGCTTTGTGCAGCTC
TTCAATAAAGATAGCGTCAGCACGGCGCAGCAAATCGCAATACTCTTTCTTCACTTCGCCCAATACGCGC
ACACCTAAGCCCGGCCCTGGGAAAGGATGGCGGTACAGCATGTCGTATGGCAAGCCAAGCTCCAGACCAA
TCTTGCGCACTTCATCTTTAAACAGCTCTTTCAGCGGCTCAACCAGGCCCAGCTTCATCTCTTTTGGCAA
ACCGCCCACATTGTGGTGAGATTTAATCACATGCGCTTTACCGGTAGCTGATGCAGCCGATTCGATCACA
TCAGGGTAAATCGTACCCTGTGCCAACCATTTCACCTGCTCTTGTTTACAGGCTTCTTCGTCGAAGAGTT
CGACAAAGACACGGCCAATGATTTTACGTTTCGCTTCTGGTTCGTCCACTCCCGTCAGTGCCGAAAGGAA
GCGATCCTCTGCCGCCACATGGACAATATTCAGGCCAAATTTATCGCCAAACATTTCCAAGACCTGATCT
GCTTCGTTTAAGCGTAATAGGCCGTTATCCACGAATACACAGGTCAGGCGTTTACCGATAGCGCGGTGCA
ACAACATGGCCGTCACTGAAGAGTCGACACCGCCACTTAACCCCAAGATCACATGATCGTCGCCGATTTG
CTCACGCAAACGGACAATTGCATCTTCGATAATGGTGGCAGATGTCCATAGCGCTTCGCAGCCACAGATA
CCCAGCACGAAACGCTCCAACAAACGCAGGCCTTGCTTGGTGTGTGTCACTTCAGGATGGAACTGGACAC
CATAAAAACGTTTTTCTTCGTTAGCCATAATGGCAAACGGACAGGTATCCGTGCTGGCAACCGTGACAAA
ATCAGCAGGGATCTCCGCAACTTTGTCACCGTGACTCATCCAAACATCCAATACGGCTTCGCCTGCCGGA
TTGATGGCATCTTTGATATCACGGATCAGCGCGCTGTCAGCTTTAATTTCAACTTGCGCATAACCAAATT
CACGCTGATTTGAACTCTCAACTTTACCGCCCAATTGTATCGCCATGGTCTGCATGCCATAGCACACACC
CAACACCGGTACACCAGCCGTAAACACATAGTCTGGTGCGCGCGGGCTACCGTTTTCTATCGTACTTTCA
GGGCTACCAGAGAGGATGATACCACTTGGATTAAATTCACGGATTTGGGCTTCGGTGACATCCCATGCCC
ATAGTTCACAATAGACACCAATCTCACGCACACGACGCGCCAATAATTGGGTGTACTGCGAGCCGAAATC
AAGAATAAGGATGCGATGCTTATGGATATTTTTTGTCA
Protein Sequence 
>gi|218929930|ref|YP_002347805.1| GMP synthase [Yersinia pestis CO92] MTKNIHKHRILILDFGSQYTQLLARRVREIGVYCELWAWDVTEAQIREFNPSGIILSGSPESTIENGSPRAPDYVFTAGVPVLGVCYGMQTMAIQLGGKVESSNQREFGYAQVEIKADSALIRDIKDAINPAGEAVLDVWMSHGDKVAEIPADFVTVASTDTCPFAIMANEEKRFYGVQFHPEVTHTKQGLRLLERFVLGICGCEALWTSATIIEDAIVRLREQIGDDHVILGLSGGVDSSVTAMLLHRAIGKRLTCVFVDNGLLRLNEADQVLEMFGDKFGLNIVHVAAEDRFLSALTGVDEPEAKRKIIGRVFVELFDEEACKQEQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: guaBA operon mutant is highly attenuated in mice (Oyston et al., 2010).
References
Oyston et al., 2010: Oyston PC, Mellado-Sanchez G, Pasetti MF, Nataro JP, Titball RW, Atkins HS. A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection. Microbial pathogenesis. 2010; 48(5); 191-195. [PubMed: 20096773].