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yopD from Yersinia pestis CA88-4125

Victor ID 2482
Gene Name yopD from Yersinia pestis CA88-4125
Sequence Strain (Species/Organism) Yersinia pestis CA88-4125
NCBI Gene ID 5236068
NCBI Protein GI 149192711
Locus Tag YPE_4226
Protein Accession YP_001293943.1
Other Database IDs UniProtKB-ID: A6M3U4_YERPE
UniRef100: UniRef100_Q06131
UniRef90: UniRef90_Q06131
UniRef50: UniRef50_Q06131
UniParc: UPI00000D606B
EMBL: CP000722
EMBL-CDS: ABR14859.1
RefSeq_NT: NC_009595.1
OMA: MAVVSGV
ProtClustDB: CLSK862121
Taxonomy ID 412420
Plasmid No pCD1
Gene Starting Position 56739
Gene Ending Position 57659
Gene Strand (Orientation) +
Protein Name putative secreted pore/translocation protein
DNA Sequence 
>gi|149192647:56739-57659 Yersinia pestis CA88-4125 plasmid pCD1, complete sequence
CATGACAATAAATATCAAGACAGACAGCCCAATTATCACGACCGGTTCACAGCTTGATGCCATCACTACA
GAGACAGTCAAGCAAAGCGGTGAGATTAAAAAAACAGAAGACACCCGTCATGAAGCACAAGCAATAAAGA
GTAGCGAGGCAAGCTTATCTCGGTCACAGGTGCCAGAATTGATCAAACCGAGCCAGGGAATCAATGTTGC
ATTACTGAGTAAAAGCCAGGGTGATCTTAATGGTACTTTAAGTATCTTGTTGTTGCTGTTGGAACTGGCA
CGTAAAGCGCGAGAAATGGGTTTGCAACAAAGGGATATAGAAAATAAAGCTACTATTACTGCCCAAAAGG
AGCAGGTAGCGGAGATGGTCAGCGGTGCAAAACTGATGATCGCCATGGCGGTGGTGTCTGGCATCATGGC
TGCTACTTCTACGGTTGCTAGTGCTTTTTCTATAGCGAAAGAGGTGAAAATAGTTAAACAGGAACAAATT
CTAAACAGTAATATTGCTGGCCGCGAACAACTTATTGATACAAAAATGCAGCAAATGAGTAACATTGGTG
ATAAAGCGGTAAGCAGAGAGGATATCGGGAGAATATGGAAACCAGAGCAGGTAGCGGATCAAAATAAGCT
GGCATTATTGGATAAAGAATTCAGAATGACCGACTCAAAAGCCAATGCGTTTAATGCCGCAACGCAGCCG
TTAGGACAAATGGCAAACAGTGCGATTCAAGTTCATCAAGGGTATTCTCAAGCCGAGGTCAAAGAGAAAG
AAGTCAATGCAAGTATTGCTGCCAACGAGAAGCAAAAAGCCGAAGAGGCGATGAACTATAATGATAACTT
TATGAAAGATGTCCTGCGCTTGATTGAACAATATGTTAGCAGTCATACTCACGCCATGAAAGCCGCTTTT
GGTGTTGTCTG
Protein Sequence 
>gi|149192711|ref|YP_001293943.1| putative secreted pore/translocation protein [Yersinia pestis CA88-4125] MTINIKTDSPIITTGSQLDAITTETVKQSGEIKKTEDTRHEAQAIKSSEASLSRSQVPELIKPSQGINVALLSKSQGDLNGTLSILLLLLELARKAREMGLQQRDIENKATITAQKEQVAEMVSGAKLMIAMAVVSGIMAATSTVASAFSIAKEVKIVKQEQILNSNIAGREQLIDTKMQQMSNIGDKAVSREDIGRIWKPEQVADQNKLALLDKEFRMTDSKANAFNAATQPLGQMANSAIQVHQGYSQAEVKEKEVNASIAANEKQKAEEAMNYNDNFMKDVLRLIEQYVSSHTHAMKAAFGVV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells (Rosqvist et al., 1991).
References
Rosqvist et al., 1991: Rosqvist R, Forsberg A, Wolf-Watz H. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption. Infection and immunity. 1991; 59(12); 4562-4569. [PubMed: 1937815].