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yopB from Yersinia pestis biovar Microtus str. 91001

Victor ID 2498
Gene Name yopB from Yersinia pestis biovar Microtus str. 91001
Sequence Strain (Species/Organism) Yersinia pestis biovar Microtus str. 91001
NCBI Gene ID 2767487
NCBI Protein GI 45478555
Locus Tag YP_pCD54
Protein Accession NP_995382.1
Other Database IDs UniProtKB-ID: Q7ARJ0_YERPE
UniRef100: UniRef100_O68698
UniRef90: UniRef90_Q06114
UniRef50: UniRef50_Q06114
UniParc: UPI00000D607E
EMBL: AE017043
EMBL: AL117189
EMBL-CDS: AAS58573.1
EMBL-CDS: CAB54906.1
RefSeq_NT: NC_003131.1
RefSeq_NT: NC_005813.1
GenomeReviews: AE017043_GR
GenomeReviews: AL117189_GR
KEGG: ype:YPCD1.29c
KEGG: ypm:YP_pCD54
HOGENOM: HBG299048
OMA: IFGWISA
ProtClustDB: CLSK862122
BioCyc: YPES214092:YPCD1.29C-MONOMER
Taxonomy ID 229193
Plasmid No pCD1
Gene Starting Position 39420
Gene Ending Position 40625
Gene Strand (Orientation) +
Protein Name putative Yop targeting protein YopB
DNA Sequence 
>gi|45478502:39420-40625 Yersinia pestis biovar Microtus str. 91001 plasmid pCD1, complete sequence
CATGAGTGCGTTGATAACCCATGACCGCTCAACGCCAGTAACTGGAAGTCTACTTCCCTACGTCGAGACA
CCAGCGCCCGCCCCCCTTCAGACCCAACAAGTCGCGGGAGAACTGAAGGATAAAAATGGCGGGGTGAGTT
CTCAGGGCGTACAGCTCCCTGCACCACTAGCAGTGGTTGCCAGCCAAGTTACTGAAGGACAACAGCAAGA
AGTCACTAAATTATTGGAGTCGGTCACCCGCGGCGCGGCAGGATCTCAACTGATATCAAATTATGTTTCA
GTGCTAACGAAGTTTACGCTTGCTTCACCTGATACATTTGAGATTGAGTTAGGTAAGCTAGTTTCTAATT
TAGAAGAAGTACGCAAAGACATAAAAATCGCTGATATTCAGCGTCTTCATGAACAAAACATGAAGAAAAT
TGAAGAGAATCAAGAGAAAATCAAAGAAACAGAAGAGAATGCCAAGCAAGTCAAGAAATCCGGCATCGCA
TCAAAGATTTTTGGCTGGCTCAGCGCCATAGCCTCAGTGATTGTCGGTGCCATCATGGTGGCCTCAGGGG
TAGGAGCCGTTGCCGGTGCAATGATGGTTGCCTCAGGCGTAATTGGGATGGCGAATATGGCAGTGAAACA
AGCGGCGGAAGATGGCCTGATATCCCAAGAGGCAATGAAAATATTAGGGCCGATACTCACTGCGATTGAA
GTCGCATTGACTGTAGTTTCAACCGTAATGACCTTTGGCGGTTCGGCACTAAAATGCCTGGCTAATATTG
GCGCAAAACTCGGTGCTAACACCGCAAGTCTTGTGGCTAAAGGAGCCGAGTTTTCGGCCAAAGTTGCCCA
AATTTCGACAGGCATATCAAACACTGTCGGGAGTGCAGTGACTAAATTAGGGGGCAGTTTTGCTGGTTTA
ACAATGAGCCATGCAATCCGTACAGGATCACAGGCAACACAAGTCGCCGTTGGTGTGGGCAGCGGAATAA
CTCAGACCATCAATAATAAAAAGCAAGCTGATTTACAACATAATAACGCTGATTTGGCCTTGAACAAGGC
AGACATGGCAGCGTTACAAAGTATTATTGACCGACTCAAAGAAGAGTTATCCCATTTGTCAGAGTCACAT
CAACAAGTGATGGAACTGATTTTCCAGATGATTAATGCAAAAGGTGACATGCTGCATAATTTGGCCGGCA
GACCCCATACTGTTTA
Protein Sequence 
>gi|45478555|ref|NP_995382.1| putative Yop targeting protein YopB [Yersinia pestis biovar Microtus str. 91001] MSALITHDRSTPVTGSLLPYVETPAPAPLQTQQVAGELKDKNGGVSSQGVQLPAPLAVVASQVTEGQQQEVTKLLESVTRGAAGSQLISNYVSVLTKFTLASPDTFEIELGKLVSNLEEVRKDIKIADIQRLHEQNMKKIEENQEKIKETEENAKQVKKSGIASKIFGWLSAIASVIVGAIMVASGVGAVAGAMMVASGVIGMANMAVKQAAEDGLISQEAMKILGPILTAIEVALTVVSTVMTFGGSALKCLANIGAKLGANTASLVAKGAEFSAKVAQISTGISNTVGSAVTKLGGSFAGLTMSHAIRTGSQATQVAVGVGSGITQTINNKKQADLQHNNADLALNKADMAALQSIIDRLKEELSHLSESHQQVMELIFQMINAKGDMLHNLAGRPHTV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells (HÃ¥kansson et al., 1996).
COG COG5613S, under S: Function unknown
References
Håkansson et al., 1996: Håkansson S, Schesser K, Persson C, Galyov EE, Rosqvist R, Homblé F, Wolf-Watz H. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity. The EMBO journal. 1996; 15(21); 5812-5823. [PubMed: 8918459].