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yopT from Yersinia pestis Angola

Victor ID 1934
Gene Name yopT from Yersinia pestis Angola
Sequence Strain (Species/Organism) Yersinia pestis Angola
NCBI Gene ID 5798299
NCBI Protein GI 162417779
Locus Tag YpAngola_B0016
Protein Accession YP_001604449.1
Other Database IDs UniProtKB-ID: A9R9G0_YERPG
UniRef100: UniRef100_O68703
UniRef90: UniRef90_A1JU65
UniRef50: UniRef50_A1JU65
UniParc: UPI00000D1251
EMBL: CP000902
EMBL-CDS: ABX88746.1
RefSeq_NT: NC_010157.1
GenomeReviews: CP000902_GR
KEGG: ypg:YpAngola_B0016
HOGENOM: HBG624384
OMA: PISSINH
ProtClustDB: CLSK862118
BioCyc: YPES349746:YPANGOLA_B0016-MONOMER
Taxonomy ID 349746
Plasmid No new_pCD
Gene Starting Position 10375
Gene Ending Position 11343
Gene Strand (Orientation) +
Protein Name cysteine protease YopT
DNA Sequence 
>gi|162417732:10375-11343 Yersinia pestis Angola plasmid new_pCD, complete sequence
GATGAACAGTATTCACGGACACTACCATATTCAACTATCGAATTATTCTGCCGGTGAAAACCTTCAATCA
GCTACCCTCACCGAAGGGGTGATTGGCGCACACCGAGTGAAAGTGGAAACAGCACTGTCACACTCAAACC
TGCAGAAAAAGTTATCAGCCACCATAAAACATAACCAGTCAGGCCGTTCTATGCTGGATAGAAAGTTGAC
CAGCGACGGCAAAGCTAACCAACGCAGCAGCTTTACCTTCAGTATGATTATGTATCGCATGATACATTTT
GTACTCAGCACTCGTGTGCCCGCGGTGAGAGAGTCTGTTGCAAATTACGGAGGTAACATCAATTTCAAGT
TTGCTCAGACCAAAGGGGCTTTTCTTCATAAAATAATAAAACATTCAGACACTGCTAGCGGTGTCTGTGA
GGCTTTATGTGCACATTGGATCAGGAGCCATGCACAAGGCCAAAGCTTATTTGACCAGCTCTATGTTGGC
GGGCGTAAGGGGAAATTCCAGATCGATACACTTTACTCAATTAAACAGTTGCAAATAGATGGTTGTAAAG
CAGACGTTGATCAAGATGAGGTAACACTAGATTGGTTCAAGAAAAATGGCATATCAGAACGTATGATTGA
ACGGCATTGCTTACTGCGTCCAGTTGATGTTACTGGTACGACGGAATCAGAAGGGCTGGATCAATTATTA
AACGCTATCCTTGATACTCATGGGATAGGTTACGGTTATAAAAAAATACATCTCTCAGGCCAAATGTCAG
CCCACGCCATAGCGGCGTATGTCAACGAAAAGAGTGGTGTTACTTTCTTCGATCCCAATTTCGGTGAATT
CCACTTTTCTGATAAGGAAAAGTTCCGCAAATGGTTTACTAACTCATTCTGGGGTAATTCTATGTATCAT
TATCCTCTGGGGGTGGGGCAGCGTTTTAGAGTGTTAACATTTGACTCCAAGGAGGTTTA
Protein Sequence 
>gi|162417779|ref|YP_001604449.1| cysteine protease YopT [Yersinia pestis Angola] MNSIHGHYHIQLSNYSAGENLQSATLTEGVIGAHRVKVETALSHSNLQKKLSATIKHNQSGRSMLDRKLTSDGKANQRSSFTFSMIMYRMIHFVLSTRVPAVRESVANYGGNINFKFAQTKGAFLHKIIKHSDTASGVCEALCAHWIRSHAQGQSLFDQLYVGGRKGKFQIDTLYSIKQLQIDGCKADVDQDEVTLDWFKKNGISERMIERHCLLRPVDVTGTTESEGLDQLLNAILDTHGIGYGYKKIHLSGQMSAHAIAAYVNEKSGVTFFDPNFGEFHFSDKEKFRKWFTNSFWGNSMYHYPLGVGQRFRVLTFDSKEV
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT (Iriarte and Cornelis, 1998).
References
Iriarte and Cornelis, 1998: Iriarte M, Cornelis GR. YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells. Molecular microbiology. 1998; 29(3); 915-929. [PubMed: 9723929].