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msbB from Yersinia pestis KIM 10

Victor ID 779
Gene Name msbB from Yersinia pestis KIM 10
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
NCBI Gene ID 1147194
NCBI Protein GI 22126133
Locus Tag y2247
Protein Accession NP_669556.1
Other Database IDs UniProtKB-ID: Q7CIC3_YERPE
UniRef100: UniRef100_A4TJJ5
UniRef90: UniRef90_A1JRH3
UniRef50: UniRef50_P59198
UniParc: UPI00000DCD1B
EMBL: AE009952
EMBL: AE017042
EMBL: AL590842
EMBL-CDS: AAM85807.1
EMBL-CDS: AAS62124.1
EMBL-CDS: CAL20698.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
RefSeq_NT: NC_003143.1
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
GenomeReviews: AL590842_GR
KEGG: ype:YPO2063
KEGG: ypk:y2247
KEGG: ypm:YP_1906
HOGENOM: HBG730280
OMA: VPLFPVY
ProtClustDB: PRK08943
BioCyc
Taxonomy ID 187410
Gene Starting Position 2476837
Gene Ending Position 2477799
Gene Strand (Orientation) -
Protein Name lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase
DNA Sequence 
>gi|22123922:2476837-2477799 Yersinia pestis KIM 10 chromosome, complete genome
CCTAAAGATCTTTGCGCACATAGGGCTCGGTTTCACCCTCTTTCCGGGTTTTTAACAGCTTTAAGATCCA
TGTATATTGCTCTGGATTCGGCTTAACCAACAACTCCACTTCCTCATTCATCCGGCGGGCAATATAGGCG
TCATCAGCATCCGCCAAATCATCCATTGGCGGACGGATATAGATATCAAGACGATGCTCTCTATAATTAT
AAACAGGGAACATCGGTACAATGGCCGCACGGCAGACTTTCATTAAACGGCCTATTGCCGGTAATGTCGC
CTTATAGGTCGCGAAGAAATCAACAAATTCACTTTGCTCAGGACCATAATCTTCATCAGGTAAGTAGTAA
CCCCAGAATCCTTGGCGTACTGAACTGATAAAAGGTTTGATGCCACTTTCGCGGGCATGGATCCGACCAC
CGAAATGTAAACGCGCACTGTTCCATAGATAGTCCACCAATGGATTACGTTGATGATGGAACATACCTGC
AACTGGCTTGCCCTGCTCCGCTAGCAGCATAGCCGGAATATCAATGGACCAGGCATGGGGGACCAACAAA
ATAACATTACGCTCTTGTTGTTGCAGCTCATCCAGTATTTCCTGTCCATGCCAGTGCACGCGAGTCAGCA
CTTTTTTCGGATCACGAAAACAAAGTTCTGCCATCATCATTAACGGTTGAGCTGCGGTAGCAAACATCTG
GTCAATAATGTGTTCGCGTTCAGACTCGGGTAACTCAGGCATACAATAAAGAAGATTAATACGAGCGCGA
CGACGGGCGCTTTTAGCAAATTTCCCAGCGAGACGCCCTATGCCAGCTAATAAAGGATCACGGAATTTGG
GTGGAATATAAGCGAGCGCCGCAATCGCTCCAGCACCTAACCAAACCCCCCAGAAACGCGGATGGAGGAA
GGTTTTCTGAAATACCGGAATAAAACCAGTTGCGTCATTTTTTTCTTTGTGCA
Protein Sequence 
>gi|22126133|ref|NP_669556.1| lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase [Yersinia pestis KIM10+] MHKEKNDATGFIPVFQKTFLHPRFWGVWLGAGAIAALAYIPPKFRDPLLAGIGRLAGKFAKSARRRARINLLYCMPELPESEREHIIDQMFATAAQPLMMMAELCFRDPKKVLTRVHWHGQEILDELQQQERNVILLVPHAWSIDIPAMLLAEQGKPVAGMFHHQRNPLVDYLWNSARLHFGGRIHARESGIKPFISSVRQGFWGYYLPDEDYGPEQSEFVDFFATYKATLPAIGRLMKVCRAAIVPMFPVYNYREHRLDIYIRPPMDDLADADDAYIARRMNEEVELLVKPNPEQYTWILKLLKTRKEGETEPYVRKDL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lpxM (msbB) mutant is avirulent in mice and guinea pigs (Feodorova et al., 2007).
COG COG1560M, under M: Cell wall/membrane/envelope biogenesis
References
Feodorova et al., 2007: Feodorova VA, Pan'kina LN, Savostina EP, Sayapina LV, Motin VL, Dentovskaya SV, Shaikhutdinova RZ, Ivanov SA, Lindner B, Kondakova AN, Bystrova OV, Kocharova NA, Senchenkova SN, Holst O, Pier GB, Knirel YA, Anisimov AP. A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Vaccine. 2007; 25(44); 7620-7628. [PubMed: 17913308].