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dnaE from Yersinia pestis KIM 10

Victor ID 791
Gene Name dnaE from Yersinia pestis KIM 10
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
NCBI Gene ID 1148067
NCBI Protein GI 22126996
Locus Tag y3120
Protein Accession NP_670419.1
Other Database IDs UniProtKB-ID: Q7CH18_YERPE
UniRef100: UniRef100_A9R381
UniRef90: UniRef90_A9R381
UniRef50: UniRef50_Q89AN8
UniParc: UPI00000DCA59
EMBL: AE009952
EMBL: AE017042
EMBL: AL590842
EMBL-CDS: AAM86670.1
EMBL-CDS: AAS62975.1
EMBL-CDS: CAL19724.1
RefSeq_NT: NC_004088.1
RefSeq_NT: NC_005810.1
RefSeq_NT: NC_003143.1
GenomeReviews: AE009952_GR
GenomeReviews: AE017042_GR
GenomeReviews: AL590842_GR
KEGG: ype:YPO1059
KEGG: ypk:y3120
KEGG: ypm:YP_2791
HOGENOM: HBG734490
OMA: QIVTFGT
ProtClustDB: PRK05673
BioCyc
Taxonomy ID 187410
Gene Starting Position 3430446
Gene Ending Position 3433961
Gene Strand (Orientation) -
Protein Name DNA polymerase III subunit alpha
DNA Sequence 
>gi|22123922:3430446-3433961 Yersinia pestis KIM 10 chromosome, complete genome
TTTAGTCAAATTCCAGTTCCACTTGCTCATTACCTACCAACGTTCGCAAATCGATTAATAAGCGATCGGT
GGGCGTCACGCGCCATGTGGCTCCAAACCGCAGCCGGGCGCGAGCATCTTCCCGTTGGTAATAAAGATGT
ACTGGGATCGTCCCCGCTCGATGGGGTTCCAACGACTGACGGAGACGGTTCAAAAGCTGGTCATCAATTT
GCCTGTCAGTCAGCGAGATAGCAAGCCCACTTGCATATTTTTCACGAGCTTCACTGATGTCCATTAACTC
ACGGGCGGTCATTTTAAGCCCACCACTAAAGTCATCAAAGCTGACCTGTCCGGTGGCTATCAGGATACGG
TCTTTTTCCAATAAATGCTGATATTTTTCCAATGCATCGGTGAATAACATCACCTCCAGACGACCAGAGC
GGTCATCTAGCGTACAAATACCAATGCGATTACCACGTTTTGTGACCATAACCCTTGCCGCGATCACCAA
CCCCACTGCGGTGGTCATTTTGCCCCGATCCGTCGGATGCATATCCTTCAAACGCATCCCACCGGCATAG
CGTTCGATTTCCTTGAGGTACTGAGTGATCGGATGGCCAGTTAAATACAGCCCCAGCGTTTCCCGTTCAC
CATCTAAAACAACCTGCTCCTGCCATGGCGGCACATTGGCATAGGATTGCTCAACCTGCTCAGGCGCGTC
GGCTAATACACCAAACATATCTACCTGACCAATTGCTTCGGCTTTAGCATGTTGATCTGCGGCTTTAAGC
GCATCCCCGAGAGAACTCATCAATGCTGCACGGTGTGGCCCCAAACGGTCAAATGCACCGGACATGATCA
GTTTTTCTAAAATACGCTTGTTAAGCTTTTTGGTATCGACACGGGCGCATAGGTCAAATAACTCTTTAAA
ATAGCCCCCCTCTTTACGCGCCTCCAGAATGGCTTCTATCGGCCCCTCACCTACACCTTTAATGGCACCA
ATACCATAAACAATTTCGCCATCATCGTTTACATGGAAATGGTACAAACCGCTGTTGATGTCAGGGGGCA
GAATTTTCAGCCCCATACGCCAGCATTCATCGACCAAGCCGACCACTTTGTCCGTATTATCCATATCAGC
GGTCATTACTGCAGCCATAAATTCAGCCGGATAATGGGCTTTTAACCACAACGTTTGATAGGAGACTAAT
GCATAAGCTGCCGAGTGAGATTTGTTAAAACCGTAACCTGCAAATTTCTCAACCAGGTCAAAGATTTTAA
TCGCCAGCTCACCATCAATACCCTGATTTTTCGCACCATCTTCAAATACAGAACGCTGCTTAGCCATCTC
AGCAGGGTTTTTCTTACCCATGGCACGACGCAACATGTCCGCACCACCCAGTGAGTAGCCGGACAGAACC
TGCGCAATTTGCATGACCTGTTCCTGATACAAGATAATGCCGTAGGTCGGCTCAAGCACAGGTTTCAAGG
ATTCATGTTGCCACTCAATATCTGGGTAAGATATCGCTTCCCGGCCGTGTTTACGGTCAATAAAGTTATC
AACCATCCCTGATTGTAACGGACCGGGACGAAATAACGCCACTAAGGCGATCATGTCCTCGAAGCAGTCG
GGCTTCAGGCGCTTGATCAAGTCTTTCATCCCTCTGGATTCCAGCTGGAATACTGCTGTCGTTTCCGAAC
GTTGCAGCATATCGAAGCTTTTTTTATCCTCCAGCGGAATAGAGGCGATATCAATGGGTTCCAATCCAGT
TTTAGCGCGCCGGGCGTTAATCATCTCCAACGCCCAATTAATGATGGTTAGTGTACGTAGACCGAGGAAG
TCAAACTTCACCAGCCCAGCATATTCCACATCATTTTTATCAAACTGCGTAACTGGGTTATTGCCTTCCG
CATCACAATAGAGTGGGGCAAAATCGGTAATCTTAGTGGGGGCAATAACCACGCCTCCAGCATGTTTCCC
GGCGTTTCGCGTTACTCCTTCCAGCTTACGCGCCATATCAATTAGCGCCCTGACCTCTTCATCAGCTTCA
TAAATTTCAGCTAGCTGTGGCTCCGCTGCAAACGCTTTTTCCAGTGTCATCCCCGGATCGAGTGGGATTA
ATTTTGAGATCCGATCAACAAAGCCATAGGGATGGCCTAATACACGGCCGACATCGCGGATGACCGCTTT
AGCCGCCATGGTACCGAAGGTAATTATCTGGGAAACCGCATCGCGGCCATACATTTCCGCCACGTGTTCG
ATCACCAGATCACGTTTCTCCATACAGAAGTCAACGTCGAAGTCAGGCATCGATACACGTTCCGGATTAA
GGAAGCGCTCGAACAGTAGATCAAATTCCAGTGGGTCAATATCAGTAATTTTCAGGGCATAAGCCACCAA
TGAGCCTGCACCAGAGCCACGCCCCGGCCCCACCGGTACGCCGTTATCTTTCGACCACTGGATAAACTCC
ATTACAATCAGGAAGTAACCAGGGAAGCCCATTTGGTTGATAACTTTGAGCTCGATATCCAGACGTTCAT
CATATTCTGGCCGTTTTTGCAGCCTAACCTCAGGGTCCGGAAACAGAAATTCCAAACGTTCTTCCAAACC
TTGTTTGGCTTTTTCTACCAGAAAATCTTCTGTACTCATCTCCCCTGTGGGGAACTGCGGTAAGAAATAT
TCCCCAAGGCGAATAGTGACATTACAGCGTTTGGCTATCTCAACGCTGTTGATCAACGCTTCTGGAATAT
CAGCGAACAGCTCACACATCTGTTCTTCATCGCGCATAAACTGCTGAGGGCTGTAATTCTTCGGCCGTTT
AGGATCGACCAATGTAAAACCATCATGGATAGCGACACGGATTTCATGGGCATCAAAATCCGATTCATCA
ATAAAACGCACATCATTGGTCGCAACGACAGGTAAACCACGCTCAGTGGCCAATGCCACGGCAGCATGAA
GATAGTTTTCTTCGTCTGGACGCCCGGTTCGAATAAGTTCGAGGTAATAGCAGTCTGGAAAGTGTTCCTG
ATAAAAGGCGAGACATTGATCAACCTGAACCTGGTTACCCCGTAGCAGAAATTTGCCCACATCCCCCATT
CGGCCACCAGACAGCAGAATGAGTCCTTCTTTATGTTTGATCAGCCAATCGCGATCAATGATAGGACCCG
CAGCGCCATAACCCCGTTGGTAGGCTTCTGAGATCAATAAAGTCAGATTTTGATAGCCTTCATTATTGCG
AGCCAAAACCGTGAGGTGAGCTAATTCATCACCCAGTATTTCACTTTGTACGTAGAAGTCAGCACCGATG
ATGGGTTTAATCCCCGCACCATGCGCGCTGCCGTAGAATTTCACCAGGCCACAGAGGTTAGTAAAATCGG
TAATAGCCAGAGCAGGCATACCTAATGCAGCAGCTCTTTTCACCAAAGGTCCAATCTTAGCTAATCCATC
GATCATGGAATAATCGCTATGAACACGCAGGTGGACAAAACGAGGTTCGGCCATATCCAGATACCAGAAA
TGAGTGGATTGAATCA
Protein Sequence 
>gi|22126996|ref|NP_670419.1| DNA polymerase III subunit alpha [Yersinia pestis KIM10+] MIQSTHFWYLDMAEPRFVHLRVHSDYSMIDGLAKIGPLVKRAAALGMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFYVQSEILGDELAHLTVLARNNEGYQNLTLLISEAYQRGYGAAGPIIDRDWLIKHKEGLILLSGGRMGDVGKFLLRGNQVQVDQCLAFYQEHFPDCYYLELIRTGRPDEENYLHAAVALATERGLPVVATNDVRFIDESDFDAHEIRVAIHDGFTLVDPKRPKNYSPQQFMRDEEQMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQFPTGEMSTEDFLVEKAKQGLEERLEFLFPDPEVRLQKRPEYDERLDIELKVINQMGFPGYFLIVMEFIQWSKDNGVPVGPGRGSGAGSLVAYALKITDIDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDLVIEHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPLDPGMTLEKAFAAEPQLAEIYEADEEVRALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNNPVTQFDKNDVEYAGLVKFDFLGLRTLTIINWALEMINARRAKTGLEPIDIASIPLEDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREAISYPDIEWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYSLGGADMLRRAMGKKNPAEMAKQRSVFEDGAKNQGIDGELAIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAILEARKEGGYFKELFDLCARVDTKKLNKRILEKLIMSGAFDRLGPHRAALMSSLGDALKAADQHAKAEAIGQVDMFGVLADAPEQVEQSYANVPPWQEQVVLDGERETLGLYLTGHPITQYLKEIERYAGGMRLKDMHPTDRGKMTTAVGLVIAARVMVTKRGNRIGICTLDDRSGRLEVMLFTDALEKYQHLLEKDRILIATGQVSFDDFSGGLKMTARELMDISEAREKYASGLAISLTDRQIDDQLLNRLRQSLEPHRAGTIPVHLYYQREDARARLRFGATWRVTPTDRLLIDLRTLVGNEQVELEFD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: dnaE mutant is attenuated in mice (Flashner et al., 2004).
COG COG0587L, under L: Replication, recombination and repair
References
Flashner et al., 2004: Flashner Y, Mamroud E, Tidhar A, Ber R, Aftalion M, Gur D, Lazar S, Zvi A, Bino T, Ariel N, Velan B, Shafferman A, Cohen S. Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates. Infection and immunity. 2004; 72(2); 908-915. [PubMed: 14742535].