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yopB from Yersinia pestis Angola

Victor ID 1932
Gene Name yopB from Yersinia pestis Angola
Sequence Strain (Species/Organism) Yersinia pestis Angola
NCBI Gene ID 5798275
NCBI Protein GI 162417812
Locus Tag YpAngola_B0030
Protein Accession YP_001604461.1
Other Database IDs UniProtKB-ID: A9R9H2_YERPG
UniRef100: UniRef100_O68698
UniRef90: UniRef90_Q06114
UniRef50: UniRef50_Q06114
UniParc: UPI00000D607E
EMBL: CP000902
EMBL-CDS: ABX88779.1
RefSeq_NT: NC_010157.1
GenomeReviews: CP000902_GR
KEGG: ypg:YpAngola_B0030
HOGENOM: HBG299048
OMA: IFGWISA
ProtClustDB: CLSK862122
BioCyc: YPES349746:YPANGOLA_B0030-MONOMER
Taxonomy ID 349746
Plasmid No new_pCD
Gene Starting Position 17872
Gene Ending Position 19077
Gene Strand (Orientation) -
Protein Name translocator protein YopB
DNA Sequence 
>gi|162417732:17872-19077 Yersinia pestis Angola plasmid new_pCD, complete sequence
CTTAAACAGTATGGGGTCTGCCGGCCAAATTATGCAGCATGTCACCTTTTGCATTAATCATCTGGAAAAT
CAGTTCCATCACTTGTTGATGTGACTCTGACAAATGGGATAACTCTTCTTTGAGTCGGTCAATAATACTT
TGTAACGCTGCCATGTCTGCCTTGTTCAAGGCCAAATCAGCGTTATTATGTTGTAAATCAGCTTGCTTTT
TATTATTGATGGTCTGAGTTATTCCGCTGCCCACACCAACGGCGACTTGTGTTGCCTGTGATCCTGTACG
GATTGCATGGCTCATTGTTAAACCAGCAAAACTGCCCCCTAATTTAGTCACTGCACTCCCGACAGTGTTT
GATATGCCTGTCGAAATTTGGGCAACTTTGGCCGAAAACTCGGCTCCTTTAGCCACAAGACTTGCGGTGT
TAGCACCGAGTTTTGCGCCAATATTAGCCAGGCATTTTAGTGCCGAACCGCCAAAGGTCATTACGGTTGA
AACTACAGTCAATGCGACTTCAATCGCAGTGAGTATCGGCCCTAATATTTTCATTGCCTCTTGGGATATC
AGGCCATCTTCCGCCGCTTGTTTCACTGCCATATTCGCCATCCCAATTACGCCTGAGGCAACCATCATTG
CACCGGCAACGGCTCCTACCCCTGAGGCCACCATGATGGCACCGACAATCACTGAGGCTATGGCGCTGAG
CCAGCCAAAAATCTTTGATGCGATGCCGGATTTCTTGACTTGCTTGGCATTCTCTTCTGTTTCTTTGATT
TTCTCTTGATTCTCTTCAATTTTCTTCATGTTTTGTTCATGAAGACGCTGAATATCAGCGATTTTTATGT
CTTTGCGTACTTCTTCTAAATTAGAAACTAGCTTACCTAACTCAATCTCAAATGTATCAGGTGAAGCAAG
CGTAAACTTCGTTAGCACTGAAACATAATTTGATATCAGTTGAGATCCTGCCGCGCCGCGGGTGACCGAC
TCCAATAATTTAGTGACTTCTTGCTGTTGTCCTTCAGTAACTTGGCTGGCAACCACTGCTAGTGGTGCAG
GGAGCTGTACGCCCTGAGAACTCACCCCGCCATTTTTATCCTTCAGTTCTCCCGCGACTTGTTGGGTCTG
AAGGGGGGCGGGCGCTGGTGTCTCGACGTAGGGAAGTAGACTTCCAGTTACTGGCGTTGAGCGGTCATGG
GTTATCAACGCACTCA
Protein Sequence 
>gi|162417812|ref|YP_001604461.1| translocator protein YopB [Yersinia pestis Angola] MSALITHDRSTPVTGSLLPYVETPAPAPLQTQQVAGELKDKNGGVSSQGVQLPAPLAVVASQVTEGQQQEVTKLLESVTRGAAGSQLISNYVSVLTKFTLASPDTFEIELGKLVSNLEEVRKDIKIADIQRLHEQNMKKIEENQEKIKETEENAKQVKKSGIASKIFGWLSAIASVIVGAIMVASGVGAVAGAMMVASGVIGMANMAVKQAAEDGLISQEAMKILGPILTAIEVALTVVSTVMTFGGSALKCLANIGAKLGANTASLVAKGAEFSAKVAQISTGISNTVGSAVTKLGGSFAGLTMSHAIRTGSQATQVAVGVGSGITQTINNKKQADLQHNNADLALNKADMAALQSIIDRLKEELSHLSESHQQVMELIFQMINAKGDMLHNLAGRPHTV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells (HÃ¥kansson et al., 1996).
COG COG5613S, under S: Function unknown
References
Håkansson et al., 1996: Håkansson S, Schesser K, Persson C, Galyov EE, Rosqvist R, Homblé F, Wolf-Watz H. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity. The EMBO journal. 1996; 15(21); 5812-5823. [PubMed: 8918459].