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yopE from Yersinia pestis CA88-4125

Victor ID 2490
Gene Name yopE from Yersinia pestis CA88-4125
Sequence Strain (Species/Organism) Yersinia pestis CA88-4125
NCBI Gene ID 5236139
NCBI Protein GI 149192652
Locus Tag YPE_4152
Protein Accession YP_001293884.1
Other Database IDs UniProtKB-ID: A6M3N5_YERPE
UniRef100: UniRef100_P31493
UniRef90: UniRef90_P31493
UniRef50: UniRef50_P31493
UniParc: UPI000013BCAD
EMBL: CP000722
EMBL-CDS: ABR14800.1
RefSeq_NT: NC_009595.1
OMA: KSEQYAN
ProtClustDB: CLSK862154
Taxonomy ID 412420
Plasmid No pCD1
Gene Starting Position 2389
Gene Ending Position 3048
Gene Strand (Orientation) -
Protein Name Translocated host-GTPase-activating protein
DNA Sequence 
>gi|149192647:2389-3048 Yersinia pestis CA88-4125 plasmid pCD1, complete sequence
ATCACATCAATGACAGTAATTTCTGCATCTGTTGCGCCAGCCCTTTGATCTCATTTGCTGCCTGCGTTAG
ATCAACGCCACTGGCGACGTACGCGCTGGCCGCCCCACCAATAGTTCCCCACTGCGAGAAGGGAATACCA
CAAACAGGCGTGTTTAAGATGGCACTGGCCTCAGCTTGCAATTCCCCACCACAAAACTGCATCAGCCCTT
GGCATTGAGTGATACTGCCACGAAGAGGGCCGCTGCCCGTAGCGAACTGATCATGATTTTTCTGCAGCAT
CTCTGCATCCAAGCTATTCAACTGCTGCATGTATTTTGGCAGCGTCTCAGCAGCAAGTTGCTTGATACTG
TCACTGAAAGACGTAGGACTTGGCATTTGTGCAGGTGTGGGTGCTGGTGTCACCACCGGTTTATGGCTCC
CCTCCGAGAACATGCGTTGGATAAACCCAATCACAGAGTGGGCCACTGATGATAACCTCTCAATGATACG
GCTGGCTAAGCTGGAACCCTGAGGGCTTTCAGTGCGCCCGGCCAGATTGTTTGCATATTGATCACTTGTT
TGCTGTGAGACTGAGCGCCCAGACATTTCTCCTACGCTGCTAGATCCTGACACAGATGTCGGCAGGGGCA
GTGATGTAGAAATAAATGATGATATTTTCA
Protein Sequence 
>gi|149192652|ref|YP_001293884.1| translocated host-GTPase-activating protein [Yersinia pestis CA88-4125] MKISSFISTSLPLPTSVSGSSSVGEMSGRSVSQQTSDQYANNLAGRTESPQGSSLASRIIERLSSVAHSVIGFIQRMFSEGSHKPVVTPAPTPAQMPSPTSFSDSIKQLAAETLPKYMQQLNSLDAEMLQKNHDQFATGSGPLRGSITQCQGLMQFCGGELQAEASAILNTPVCGIPFSQWGTIGGAASAYVASGVDLTQAANEIKGLAQQMQKLLSLM
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice (Rosqvist et al., 1990).
References
Rosqvist et al., 1990: Rosqvist R, Forsberg A, Rimpiläinen M, Bergman T, Wolf-Watz H. The cytotoxic protein YopE of Yersinia obstructs the primary host defence. Molecular microbiology. 1990; 4(4); 657-667. [PubMed: 2191183].