| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
SPy_0019 |
Streptococcus pyogenes M1 GAS |
900379
|
|
15674263
|
SPy_0019 |
AE004092 |
NP_268436 |
putative secreted protein |
Virulence factor |
MUTATION: SPy_0019 (cdhA) mutant has severe cell division, growth defects and is attenuated in mice [Ref6929:Pancholi et al., 2010]. |
20643653
|
|
|
nga |
Streptococcus pyogenes M1 GAS |
900488
|
|
15674370
|
SPy_0165 |
|
NP_268544.1 |
NAD glycohydrolase |
Virulence factor |
MUTATION: nga mutant is attenuated in mice [Ref6930:Tatsuno et al., 2010]. |
20470439
|
|
|
speJ from Streptococcus pyogenes M1 GAS |
Streptococcus pyogenes M1 GAS |
900684
|
|
15674561
|
SPy_0436 |
|
NP_268735.1 |
putative exotoxin (superantigen) |
Virulence factor |
TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS [Ref6931:McCormick et al., 2001]. |
11179302
|
|
|
sagA from Streptococcus pyogenes M1 GAS |
Streptococcus pyogenes M1 GAS |
900920
|
|
15674789
|
SPy_0738 |
|
NP_268963.1 |
streptolysin S associated protein |
Virulence factor |
MUTATION: sagA mutant is attenuated in mice [Ref6932:Betschel et al., 1998]. |
9529097
|
|
|
lsp from Streptococcus pyogenes M1 GAS |
Streptococcus pyogenes M1 GAS |
900995
|
|
15674864
|
SPy_0826 |
|
NP_269038.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. |
19398546
|
|
|
dltA from Streptococcus pyogenes M1 GAS |
Streptococcus pyogenes M1 GAS |
901401
|
|
15675261
|
SPy_1312 |
|
NP_269435.1 |
D-alanine--poly(phosphoribitol) ligase subunit 1 |
Virulence factor |
MUTATION: dltA mutant was diminished in its ability to adhere to and invade cultured human pharyngeal epithelial cells [Ref6934:Kristian et al., 2005]. |
16166534
|
|
|
scpA from Streptococcus pyogenes M1 GAS |
Streptococcus pyogenes M1 GAS |
901674
|
|
15675796
|
SPy_2010 |
|
NP_269970.1 |
C5A peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
sic |
Streptococcus pyogenes M1 GAS |
901676
|
|
15675798
|
SPy_2016 |
|
NP_269972.1 |
inhibitor of complement-mediated lysis |
Virulence factor |
MUTATION: sic mutant was phagocytosed and killed by human polymorphonuclear leukocytes significantly better than the wild-type strain [Ref6936:Hoe et al., 2002]. |
12032337
|
|
|
emm1 |
Streptococcus pyogenes M1 GAS |
901677
|
|
15675799
|
SPy_2018 |
|
NP_269973.1 |
M protein type 1 |
Virulence factor |
MUTATION: emm1 mutant had greatly reduced invasion of HeLa cells [Ref6937:Dombek et al., 1999]. |
10048029
|
|
|
mga from Streptococcus pyogenes M1 GAS |
Streptococcus pyogenes M1 GAS |
901678
|
|
15675800
|
SPy_2019 |
|
NP_269974.1 |
M protein trans-acting positive regulator |
Virulence factor |
MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. |
18588968
|
|
|
speB from Streptococcus pyogenes M1 GAS |
Streptococcus pyogenes M1 GAS |
901690
|
|
15675811
|
SPy_2039 |
|
NP_269985.1 |
pyrogenic exotoxin B |
Virulence factor |
MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains [Ref6939:Chiang-Ni and Wu, 2008]. |
18796357
|
|
|
gidA from Streptococcus pyogenes M1 GAS |
Streptococcus pyogenes M1 GAS |
901831
|
|
15675920
|
SPy_2185 |
|
NP_270094.1 |
tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA |
Virulence factor |
MUTATION: gidA mutant is highly attenuated in the murine ulcer model of soft tissue infection [Ref6940:Cho and Caparon, 2008]. |
18426891
|
|
|
SPy_1633 |
Streptococcus pyogenes M1 GAS |
901885
|
|
15675508
|
SPy_1633 |
AE004092 |
NP_269682 |
hypothetical protein |
Virulence factor |
MUTATION: SPy_1633 (cvfA) mutant is attenuated in mice [Ref6941:Kang et al., 2010]. |
20385762
|
|
|
SPy_1718 |
Streptococcus pyogenes M1 GAS |
901955
|
|
15675569
|
SPy_1718 |
AE004092 |
NP_269743 |
putative esterase |
Virulence factor |
MUTATION: SPy_1718 (sse) mutant is attenuated in mice [Ref6942:Zhu et al., 2009]. |
19805529
|
|
|
fba from Streptococcus pyogenes M1 GAS |
Streptococcus pyogenes M1 GAS |
902096
|
|
15675705
|
SPy_1889 |
|
NP_269879.1 |
fructose-bisphosphate aldolase |
Virulence factor |
MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection [Ref6943:Terao et al., 2001]. |
11679068
|
|
|
spyM18_1239 |
Streptococcus pyogenes MGAS8232 |
993646
|
|
19746214
|
spyM18_1239 |
|
NP_607350.1 |
putative exotoxin precursor (SpeM) |
Virulence factor |
TOXIN: Purified SpeM is pyrogenic and mitogenic for rabbit splenocytes and human peripheral blood mononuclear cells in picogram amounts. SpeM was lethal in one model of streptococcal toxic shock [Ref6952:Smoot et al., 2002]. |
12438391
|
|
|
spyM18_1238 |
Streptococcus pyogenes MGAS8232 |
994087
|
|
19746213
|
spyM18_1238 |
|
NP_607349.1 |
putative exotoxin precursor (SpeL) |
Virulence factor |
TOXIN: Purified SpeL is pyrogenic and mitogenic for rabbit splenocytes and human peripheral blood mononuclear cells in picogram amounts. SpeL was lethal in two animal models of streptococcal toxic shock [Ref6952:Smoot et al., 2002]. |
12438391
|
|
|
mga from Streptococcus pyogenes MGAS8232 |
Streptococcus pyogenes MGAS8232 |
994370
|
|
19746912
|
spyM18_2077 |
|
NP_608048.1 |
positive regulatory protein Mga |
Virulence factor |
MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. |
18588968
|
|
|
scpA from Streptococcus pyogenes MGAS8232 |
Streptococcus pyogenes MGAS8232 |
994764
|
|
19746910
|
spyM18_2074 |
|
NP_608046.1 |
C5A peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
speA |
Streptococcus pyogenes MGAS8232 |
995014
|
|
19745506
|
spyM18_0393 |
|
NP_606642.1 |
exotoxin type A precursor |
Virulence factor |
TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits [Ref6953:Lee and Schlievert, 1989]. |
2504778
|
|
|
sagA from Streptococcus pyogenes MGAS8232 |
Streptococcus pyogenes MGAS8232 |
995250
|
|
19745828
|
spyM18_0799 |
|
NP_606964.1 |
streptolysin S associated protein |
Virulence factor |
MUTATION: sagA mutant is attenuated in mice [Ref6932:Betschel et al., 1998]. |
9529097
|
|
|
SpyM3_0013 |
Streptococcus pyogenes MGAS315 |
1008327
|
|
21909549
|
SpyM3_0013 |
|
NP_663817.1 |
putative amino acid permease |
Virulence factor |
MUTATION: SpyM3_0013 mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. |
19223485
|
|
|
SpyM3_0104 |
Streptococcus pyogenes MGAS315 |
1008418
|
|
21909640
|
SpyM3_0104 |
AE014074 |
NP_663908 |
protein F2 like fibronectin-binding protein |
Virulence factor |
MUTATION: F2 like fibronectin-binding protein mutant had attenuated attachment to to HEp-2 epithelial cells [Ref6955:Kreikemeyer et al., 2004]. |
14749329
|
|
|
slo |
Streptococcus pyogenes MGAS315 |
1008444
|
|
21909666
|
SpyM3_0130 |
|
NP_663934.1 |
streptolysin O |
Virulence factor |
MUTATION: slo mutant was attenuated in mice [Ref6956:Limbago et al., 2000]. |
11035749
|
|
|
atmB |
Streptococcus pyogenes MGAS315 |
1008547
|
|
21909769
|
SpyM3_0233 |
|
NP_664037.1 |
ABC transporter substrate-binding protein |
Virulence factor |
MUTATION: atmB mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. |
19223485
|
|
|
SpyM3_0385 |
Streptococcus pyogenes MGAS315 |
1008699
|
|
21909921
|
SpyM3_0385 |
AE014074 |
NP_664189 |
UDP-glucose 6-dehydrogenase |
Virulence factor |
MUTATION: SpyM3_0385 mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. |
19223485
|
|
|
SpyM3_0386 |
Streptococcus pyogenes MGAS315 |
1008700
|
|
21909922
|
SpyM3_0386 |
AE014074 |
NP_664190 |
putative efflux protein |
Virulence factor |
MUTATION: SpyM3_0386 mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. |
19223485
|
|
|
lsp from Streptococcus pyogenes MGAS315 |
Streptococcus pyogenes MGAS315 |
1008870
|
|
21910092
|
SpyM3_0556 |
|
NP_664360.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. |
19398546
|
|
|
salT |
Streptococcus pyogenes MGAS315 |
1009964
|
|
21911185
|
SpyM3_1649 |
|
NP_665453.1 |
putative salivaricin A modification enzyme |
Virulence factor |
MUTATION: salT mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. |
19223485
|
|
|
scpA from Streptococcus pyogenes MGAS315 |
Streptococcus pyogenes MGAS315 |
1010041
|
|
21911262
|
SpyM3_1726 |
|
NP_665530.1 |
C5A peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
emm3 |
Streptococcus pyogenes MGAS315 |
1010042
|
|
21911263
|
SpyM3_1727 |
|
NP_665531.1 |
antiphagocytic M protein, type 3 |
Virulence factor |
MUTATION: emm3 mutant has reduced adherence to and internalization into HEp-2 cells compared to the wild type [Ref6957:Eyal et al., 2003]. |
14522456
|
|
|
mga from Streptococcus pyogenes MGAS315 |
Streptococcus pyogenes MGAS315 |
1010043
|
|
21911264
|
SpyM3_1728 |
|
NP_665532.1 |
M protein trans-acting positive regulator, multi-gene activator |
Virulence factor |
MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. |
18588968
|
|
|
speB from Streptococcus pyogenes MGAS315 |
Streptococcus pyogenes MGAS315 |
1010057
|
|
21911278
|
SpyM3_1742 |
|
NP_665546.1 |
pyrogenic exotoxin B |
Virulence factor |
MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains [Ref6939:Chiang-Ni and Wu, 2008]. |
18796357
|
|
|
SpyM3_1795 |
Streptococcus pyogenes MGAS315 |
1010110
|
|
21911331
|
SpyM3_1795 |
AE014074 |
NP_665599 |
hypothetical protein |
Virulence factor |
MUTATION: SpyM3_1795 mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. |
19223485
|
|
|
hasA |
Streptococcus pyogenes MGAS315 |
1010166
|
|
21911387
|
SpyM3_1851 |
|
NP_665655.1 |
hyaluronan synthase |
Virulence factor |
MUTATION: hasA mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. |
19223485
|
|
|
SPs0560 |
Streptococcus pyogenes SSI-1 |
1065796
|
|
28895472
|
SPs0560 |
|
NP_801822.1 |
SpeA precursor |
Virulence factor |
TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits [Ref6953:Lee and Schlievert, 1989]. |
2504778
|
|
|
M6_Spy0741 |
Streptococcus pyogenes MGAS10394 |
2941480
|
|
50914087
|
M6_Spy0741 |
|
YP_060059.1 |
SpeA variant |
Virulence factor |
TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits [Ref6953:Lee and Schlievert, 1989]. |
2504778
|
|
|
speJ from Streptococcus pyogenes MGAS6180 |
Streptococcus pyogenes MGAS6180 |
3573258
|
|
71903011
|
M28_Spy0345 |
|
YP_279814.1 |
exotoxin type J precursor |
Virulence factor |
TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS [Ref6931:McCormick et al., 2001]. |
11179302
|
|
|
scpA from Streptococcus pyogenes MGAS6180 |
Streptococcus pyogenes MGAS6180 |
3574429
|
|
71904362
|
M28_Spy1700 |
|
YP_281165.1 |
C5A peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
mga from Streptococcus pyogenes MGAS6180 |
Streptococcus pyogenes MGAS6180 |
3574433
|
|
71904366
|
M28_Spy1704 |
|
YP_281169.1 |
M protein trans-acting positive regulator (Mga) |
Virulence factor |
MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. |
18588968
|
|
|
lsp from Streptococcus pyogenes MGAS6180 |
Streptococcus pyogenes MGAS6180 |
3574788
|
|
71903283
|
M28_Spy0617 |
|
YP_280086.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. |
19398546
|
|
|
gidA from Streptococcus pyogenes MGAS5005 |
Streptococcus pyogenes MGAS5005 |
3571047
|
|
71911651
|
M5005_Spy_1838 |
|
YP_283201.1 |
tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA |
Virulence factor |
MUTATION: gidA mutant is highly attenuated in the murine ulcer model of soft tissue infection [Ref6940:Cho and Caparon, 2008]. |
18426891
|
|
|
speB from Streptococcus pyogenes MGAS5005 |
Streptococcus pyogenes MGAS5005 |
3571136
|
|
71911548
|
M5005_Spy_1735 |
|
YP_283098.1 |
streptococcal pyrogenic exotoxin B |
Virulence factor |
MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains [Ref6939:Chiang-Ni and Wu, 2008]. |
18796357
|
|
|
scpA from Streptococcus pyogenes MGAS5005 |
Streptococcus pyogenes MGAS5005 |
3571155
|
|
71911528
|
M5005_Spy_1715 |
|
YP_283078.1 |
C5A peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
mga from Streptococcus pyogenes MGAS5005 |
Streptococcus pyogenes MGAS5005 |
3571160
|
|
71911533
|
M5005_Spy_1720 |
|
YP_283083.1 |
trans-acting positive regulator |
Virulence factor |
MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. |
18588968
|
|
|
smeZ |
Streptococcus pyogenes MGAS5005 |
3571180
|
|
71911515
|
M5005_Spy_1702 |
|
YP_283065.1 |
mitogenic exotoxin Z |
Virulence factor |
MUTATION: smeZ mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. |
19223485
|
|
|
fba from Streptococcus pyogenes MGAS5005 |
Streptococcus pyogenes MGAS5005 |
3571297
|
|
71911420
|
M5005_Spy_1607 |
|
YP_282970.1 |
fructose-bisphosphate aldolase |
Virulence factor |
MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection [Ref6943:Terao et al., 2001]. |
11679068
|
|
|
M5005_Spy_1305 |
Streptococcus pyogenes MGAS5005 |
3571619
|
|
71911118
|
M5005_Spy_1305 |
|
YP_282668.1 |
two-component response regulator |
Virulence factor |
MUTATION: In a murine skin infection model, an insertion mutation in the response regulator gene, trxR (M5005_Spy_1305), led to a significant reduction in lesion size, lesion severity, and lethality [Ref6967:Leday et al., 2008]. |
18678666
|
|
|
grab |
Streptococcus pyogenes MGAS5005 |
3571808
|
|
71910919
|
M5005_Spy_1106 |
|
YP_282469.1 |
protein G-related alpha 2M-binding protein |
Virulence factor |
MUTATION: grab mutant is attenuated in mice when injected intraperitoneally [Ref6968:Rasmussen et al., 1999]. |
10336419
|
|
|
dltA from Streptococcus pyogenes MGAS5005 |
Streptococcus pyogenes MGAS5005 |
3571853
|
|
71910886
|
M5005_Spy_1073 |
|
YP_282436.1 |
D-alanine--poly(phosphoribitol) ligase subunit 1 |
Virulence factor |
MUTATION: dltA mutant was diminished in its ability to adhere to and invade cultured human pharyngeal epithelial cells [Ref6934:Kristian et al., 2005]. |
16166534
|
|
|
lsp from Streptococcus pyogenes MGAS5005 |
Streptococcus pyogenes MGAS5005 |
3572266
|
|
71910450
|
M5005_Spy_0637 |
|
YP_282000.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. |
19398546
|
|
|
sagA from Streptococcus pyogenes MGAS5005 |
Streptococcus pyogenes MGAS5005 |
3572347
|
|
71910375
|
M5005_Spy_0562 |
|
YP_281925.1 |
streptolysin S precursor |
Virulence factor |
MUTATION: sagA mutant is attenuated in mice [Ref6932:Betschel et al., 1998]. |
9529097
|
|
|
ccpA |
Streptococcus pyogenes MGAS5005 |
3572479
|
|
71910237
|
M5005_Spy_0424 |
|
YP_281787.1 |
catabolite control protein A |
Virulence factor |
MUTATION: ccpA mutant is attenuated in mice [Ref6969:Shelburne et al., 2010]. |
20333240
|
|
|
speJ from Streptococcus pyogenes MGAS5005 |
Streptococcus pyogenes MGAS5005 |
3572567
|
|
71910169
|
M5005_Spy_0356 |
|
YP_281719.1 |
exotoxin type J precursor |
Virulence factor |
TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS [Ref6931:McCormick et al., 2001]. |
11179302
|
|
|
covS |
Streptococcus pyogenes MGAS5005 |
3572612
|
|
71910097
|
M5005_Spy_0283 |
|
YP_281647.1 |
transmembrane histidine kinase |
Virulence factor |
MUTATION: covS mutant has reduced capacity to bind to epithelial cell layers [Ref6970:Hollands et al., 2010]. |
20507231
|
|
|
oppA |
Streptococcus pyogenes MGAS5005 |
3572677
|
|
71910063
|
M5005_Spy_0249 |
|
YP_281613.1 |
oligopeptide-binding protein |
Virulence factor |
MUTATION: oppA mutant caused less mortality and tissue damage than the wild-type strain when inoculated into BALB/c mice via an air pouch [Ref6971:Wang et al., 2005]. |
15845494
|
|
|
perR |
Streptococcus pyogenes MGAS5005 |
3572745
|
|
71909975
|
M5005_Spy_0161 |
|
YP_281525.1 |
ferric uptake regulation protein |
Virulence factor |
MUTATION: perR mutant is attenuated in mouse air sac model [Ref6972:Ricci et al., 2002]. |
12183543
|
|
|
lsp from Streptococcus pyogenes MGAS9429 |
Streptococcus pyogenes MGAS9429 |
4060566
|
|
94988323
|
MGAS9429_Spy0692 |
|
YP_596424.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. |
19398546
|
|
|
scpA from Streptococcus pyogenes MGAS9429 |
Streptococcus pyogenes MGAS9429 |
4061049
|
|
94989350
|
MGAS9429_Spy1720 |
|
YP_597451.1 |
C5A peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
scpA from Streptococcus pyogenes MGAS10270 |
Streptococcus pyogenes MGAS10270 |
4063044
|
|
94991291
|
MGAS10270_Spy1782 |
|
YP_599391.1 |
C5A peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
lsp from Streptococcus pyogenes MGAS10270 |
Streptococcus pyogenes MGAS10270 |
4063392
|
|
94990202
|
MGAS10270_Spy0693 |
|
YP_598302.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. |
19398546
|
|
|
fba from Streptococcus pyogenes MGAS10270 |
Streptococcus pyogenes MGAS10270 |
4064175
|
|
94991185
|
MGAS10270_Spy1676 |
|
YP_599285.1 |
fructose-bisphosphate aldolase |
Virulence factor |
MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection [Ref6943:Terao et al., 2001]. |
11679068
|
|
|
scpA from Streptococcus pyogenes MGAS2096 |
Streptococcus pyogenes MGAS2096 |
4064563
|
|
94993241
|
MGAS2096_Spy1744 |
|
YP_601340.1 |
C5A peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
lsp from Streptococcus pyogenes MGAS2096 |
Streptococcus pyogenes MGAS2096 |
4065311
|
|
94992200
|
MGAS2096_Spy0703 |
|
YP_600299.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. |
19398546
|
|
|
fba from Streptococcus pyogenes MGAS10750 |
Streptococcus pyogenes MGAS10750 |
4066760
|
|
94995059
|
MGAS10750_Spy1663 |
|
YP_603157.1 |
fructose-bisphosphate aldolase |
Virulence factor |
MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection [Ref6943:Terao et al., 2001]. |
11679068
|
|
|
scpA from Streptococcus pyogenes MGAS10750 |
Streptococcus pyogenes MGAS10750 |
4066822
|
|
94995203
|
MGAS10750_Spy1807 |
|
YP_603301.1 |
C5A peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
lsp from Streptococcus pyogenes MGAS10750 |
Streptococcus pyogenes MGAS10750 |
4067861
|
|
94994122
|
MGAS10750_Spy0726 |
|
YP_602220.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. |
19398546
|
|
|
lsp from Streptococcus pyogenes str. Manfredo |
Streptococcus pyogenes str. Manfredo |
4963525
|
|
139473996
|
SpyM51170 |
|
YP_001128712.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. |
19398546
|
|
|
scpA from Streptococcus pyogenes str. Manfredo |
Streptococcus pyogenes str. Manfredo |
4964259
|
|
139474482
|
SpyM51681 |
|
YP_001129198.1 |
C5A peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
fba from Streptococcus pyogenes NZ131 |
Streptococcus pyogenes NZ131 |
6985084
|
|
209560042
|
Spy49_1559c |
|
YP_002286514.1 |
fructose-bisphosphate aldolase |
Virulence factor |
MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection [Ref6943:Terao et al., 2001]. |
11679068
|
|
|
ska |
Streptococcus pyogenes NZ131 |
6985239
|
|
209560110
|
Spy49_1630 |
|
YP_002286582.1 |
Streptokinase |
Virulence factor |
MUTATION: ska mutant was attenuated in mouse acute poststreptococcal glomerulonephritis model [Ref6988:Nordstrand et al., 2000]. |
10678902
|
|
|
scpA from Streptococcus pyogenes NZ131 |
Streptococcus pyogenes NZ131 |
6985276
|
|
209560146
|
Spy49_1669c |
|
YP_002286618.1 |
C5a peptidase precursor |
Virulence factor |
MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. |
9119483
|
|
|
mga from Streptococcus pyogenes NZ131 |
Streptococcus pyogenes NZ131 |
6985280
|
|
209560150
|
Spy49_1673c |
|
YP_002286622.1 |
M protein trans-acting positive regulator (Mga) |
Virulence factor |
MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. |
18588968
|
|
|
speB from Streptococcus pyogenes NZ131 |
Streptococcus pyogenes NZ131 |
6985296
|
|
209560166
|
Spy49_1690c |
|
YP_002286638.1 |
Strepotococcal cysteine protease (Streptopain) / Streptococcal pyrogenic exotoxin B (SpeB) |
Virulence factor |
MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains [Ref6939:Chiang-Ni and Wu, 2008]. |
18796357
|
|
|
sagA from Streptococcus pyogenes NZ131 |
Streptococcus pyogenes NZ131 |
6985582
|
|
209559117
|
Spy49_0568 |
|
YP_002285589.1 |
Streptolysin S associated protein (SagA) |
Virulence factor |
MUTATION: sagA mutant is attenuated in mice [Ref6989:Eberhard et al., 2001]. |
11801184
|
|
|
lsp from Streptococcus pyogenes NZ131 |
Streptococcus pyogenes NZ131 |
6985658
|
|
209559191
|
Spy49_0647 |
|
YP_002285663.1 |
lipoprotein signal peptidase |
Virulence factor |
MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. |
19398546
|
|
|
hyaluronic acid capsule |
Streptococcus pyogenes |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: A mutant acapsular strain TX72 (with a mutation in hasA) was avirulent in mice and sensitive to phagocytic killing in vitro [Ref7307:Wessels et al., 1994]. |
8300204
|
