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emm1

Victor ID 4279
Gene Name emm1
Sequence Strain (Species/Organism) Streptococcus pyogenes M1 GAS
NCBI Gene ID 901677
NCBI Protein GI 15675799
Locus Tag SPy_2018
Protein Accession NP_269973.1
Other Database IDs UniProtKB-ID: Q99XV0_STRP1
UniRef100: UniRef100_Q99XV0
UniRef90: UniRef90_Q05464
UniRef50: UniRef50_P19401
UniParc: UPI00000C7EF7
EMBL: AE004092
EMBL-CDS: AAK34694.1
RefSeq_NT: NC_002737.1
EnsemblGenome: EBSTRG00000000024.
EnsemblGenome_TRS: EBSTRT00000000024
EnsemblGenome_PRO: EBSTRP00000000024
GenomeReviews: AE004092_GR
KEGG: spy:SPy_2018
HOGENOM: HBG702666
OMA: VERHYLR
ProtClustDB: CLSK390980
BioCyc: SPYO160490:SPY2018-MONOMER
Taxonomy ID 160490
Gene Starting Position 1683786
Gene Ending Position 1685240
Gene Strand (Orientation) -
Protein Name M protein type 1
DNA Sequence 
>gi|15674250:1683786-1685240 Streptococcus pyogenes M1 GAS chromosome, complete genome
CTTAGTTTTCTTCTTTGCGTTTTACAACTGCTGCTACTCCAGCTGTTGCCATAACAGTAAGGGCTGCCGC
TGTGAAGAATGGGTTAGCTGTTTCACCTGTTGATGGTAACTGTCTCTTAGTTTCCTTCATTGGTGCTTTG
TTTTGGTTAGGTTTTGTACCTGCTTGTGGTGCTTGACCTTTACCTGGAACAGCTTTGTTTCCTGGTTTTG
TATCAGGGGTTTGTGAGTCTGATGCTTTTCCAGCTCTTAGTTTTGCAAGTTCTTCAGCTTGTTTCGCTAA
TTGTTCTTTGAGTGCTTTTGCTTCTGCTTCAAGTTTTGCTTGTAGTTCAGCTTTTTCTTTTTCTGTTAAT
TTCTTGCTTTCTTCAAGCTCTTTGTTAAGTTTTTCAAGAGCAGCTAATTTGCTGTTTGCTTCTTCTAAAG
CTTTTTCAACTTGTTTCTTAGCTTCACGTGATGCGTCCAAGTCACGGCGAAGGCCTTGACGGCTTGCGTC
TGAGATTTGTTTTTCTTCTTTAACCTTATCAAGTTCAGCAGTCAAGTTTGCTAAATCTTTTTCAACCTGT
TTCTTAGCTTCACGTGATGCGTCCAAGTCACGGCGAAGGCCTTGACGGCTTGCGTCTGAGATTTGTTTGT
CTTCTTTAACCTTATCAAGTTCAGCAGTCAAGTTTGCTAAATCTTTTTCAACCTGTTTCTTAGCTTCACG
TGATGCGTCCAAGTCACGACGAAGGCTTTGACGACTTGCGTCTGAGATTTGTTTTTCTTCCTCAAGTTTT
GCTTTTTCGATCGTTAGCTGCTCTTTTTCAGATGAAAGTTGATCAAGTTCAAGTTTTGCATTGCCTAAAA
GATTACGATTAATCTCTTGTTCTCTAGTAATCGTTTCTAACTCTTTTTCTAAGACGTTAGCTCTATTATA
GTCCTGACTCGCTTGGTCTATCGCTAATTCAAGAGCTTTCTTTTTCTCTTCTAACTCTTTTTCTAAAGCG
GTAGCTCTATGGTAGTCCCGACTTGCCTGGTCTATCGCTAATTCAAGAGCTTCCTTTTTCTCTTCTAACT
CTTTTTCAAGTCTTTGTCTATCCCAACTTGTTGATTCCTTTGCTAAGTCATAGTCTTGTTGTAGTTCTTT
TAATTTAGTTTCTAAATCTTTACGCTGGTCTTCTAAGGCTTGTTTTGCTTTTTCAAGTTCTTCAGCTCTC
TTAAAATCTCTTCCTGCAACTTCCATTGCATTCTCTAATCTCGCTTTTAAGTCCTTGTTTTCGTAACGTA
AACGTATATTTTGTATTGCGGGATTGTTTGCTGCAAGATCTTCTATAACTTCCCTAGGATTACCATCACC
GTTAGCCTTAACCTCTGTTTGATTCGCAAAACCTGCCCCTAAAACAGTCAAAGCTACCGCTACTGAAGCC
GTTCCTGTTTTTAATTTTCTAAGCGAATAGTGTCTATTCGTGTTATTTTTAGCCA
Protein Sequence 
>gi|15675799|ref|NP_269973.1| M protein type 1 [Streptococcus pyogenes M1 GAS] MAKNNTNRHYSLRKLKTGTASVAVALTVLGAGFANQTEVKANGDGNPREVIEDLAANNPAIQNIRLRYENKDLKARLENAMEVAGRDFKRAEELEKAKQALEDQRKDLETKLKELQQDYDLAKESTSWDRQRLEKELEEKKEALELAIDQASRDYHRATALEKELEEKKKALELAIDQASQDYNRANVLEKELETITREQEINRNLLGNAKLELDQLSSEKEQLTIEKAKLEEEKQISDASRQSLRRDLDASREAKKQVEKDLANLTAELDKVKEDKQISDASRQGLRRDLDASREAKKQVEKDLANLTAELDKVKEEKQISDASRQGLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEQLAKQAEELAKLRAGKASDSQTPDTKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAAVVKRKEEN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: emm1 mutant had greatly reduced invasion of HeLa cells (Dombek et al., 1999).
COG COG1196D, under D: Cell cycle control, cell division, chromosome partitioning
References
Dombek et al., 1999: Dombek PE, Cue D, Sedgewick J, Lam H, Ruschkowski S, Finlay BB, Cleary PP. High-frequency intracellular invasion of epithelial cells by serotype M1 group A streptococci: M1 protein-mediated invasion and cytoskeletal rearrangements. Molecular microbiology. 1999; 31(3); 859-870. [PubMed: 10048029].