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mga from Streptococcus pyogenes MGAS315

Victor ID 4332
Gene Name mga from Streptococcus pyogenes MGAS315
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS315
NCBI Gene ID 1010043
NCBI Protein GI 21911264
Locus Tag SpyM3_1728
Protein Accession NP_665532.1
Other Database IDs UniProtKB-ID: Q8K5P8_STRP3
UniRef100: UniRef100_Q4QSS3
UniRef90: UniRef90_Q1JJR1
UniRef50: UniRef50_P19401
UniParc: UPI000000B113
EMBL: AE014074
EMBL: BA000034
EMBL-CDS: AAM80335.1
EMBL-CDS: BAC64821.1
RefSeq_NT: NC_004070.1
RefSeq_NT: NC_004606.1
EnsemblGenome: EBSTRG00000033905.
EnsemblGenome_TRS: EBSTRT00000033905
EnsemblGenome_PRO: EBSTRP00000032644
EnsemblGenome: EBSTRG00000035931.
EnsemblGenome_TRS: EBSTRT00000035931
EnsemblGenome_PRO: EBSTRP00000034581
GenomeReviews: AE014074_GR
GenomeRev
Taxonomy ID 198466
Gene Starting Position 1748130
Gene Ending Position 1749740
Gene Strand (Orientation) -
Protein Name M protein trans-acting positive regulator, multi-gene activator
DNA Sequence 
>gi|21909536:1748130-1749740 Streptococcus pyogenes MGAS315 chromosome, complete genome
TCTAACTTGTAGAGGGGGGGGCATGCAACTTGTTGGGGGGAGTGGGGAAGATAACCTCTTTGCGATGAAA
ATCCAAGGGGTTCTTGATGGGTTTGTCTAGTGGCAAGCTGTCTGCAGAGCTGATGTTTAAAAACGCATTG
AGCTTATCAATAATCGCTTCTGGAATCATTTTGTAGAAAAAGAAAATTTCTAACTCATCGCTTTTTCCTA
CCATAACATCTGTCACGATCACATCATACTGTTTTTCAATCTCTTCTAGATCGATGGTTAGAGCATCTAG
CTCATTGAAGTTTGTGATGCTAAAAAACTCTCCGATGTACTTTTTTAGGAAATTACCAACACTGTTAAAA
CTTCTTTCAATCACCAGAAGACGAATTTTTTCGTCTTTTTGATTTACTTCTAGGAAACTATTTTCCCAAG
TGATGAAAAAGGCGTAGATCAATTGGTTAGTCAACTCTGTGCTGATAGGTTCTTTCTCTGAACGCATCAG
TTTTTCTACACCTGCTACAAATGCTTTATAAAGATGAGGGTGTTCTTGCTTGTAAAAGTTGAGGTAACTT
TTTTTGTAATCGAAAAATAGGTAATTAGCGGTGATATCTTCTTCTTTCAAGACGGTAGTGTTATGAAGGA
TGACAGCTACTTCGTATTTGTTGGTGACGCTGAGATTGAGCCTGATTTCTAACTCATCAAGAAGATGAAC
CCAGTTGGTAAGATGAACCCAGTTGGTCACTTTTCGACAGCCCGTTGGTGAGTCTTGTTTGATGCTATCA
AACGCATAACCGATTTCTAATTGGTCATTAACGTGATTAGAGAACATCTCAGCTATGGTAGTCTCATCTA
GGTATAGTCCAAATTTGAGGTAAAACAAGCGTGAAAGGTCTTGGATTTCTAAGGATGATTGGATGAGCTG
AGAAAAACGGTGACTGGTTTTTTTGTTGTCGTAGACGGCAGAGTGTCCCTTGTAATAACGAATCAAGTTG
ACTGAGCTTAGTATTTTAAGGTGCTGAAATAATGTAAAATTAACCCTCACATCGACCTCTTTTATCATTA
AACTGAGTAGCCGCTCACAGTTCTTTAAGTTTAGGATTTCCCCAAAAGGCCACTCTGAGATTTTATAGGC
TTCCGAAAAATACTTGAGGTAAAATAGTCGAATCTGGTGTTCATCTCCTGATACTTGTACGGGACTAGTT
AAAATAGTAATACCAAAGGTATGCATCAAATAGGCATTGGTTTTTTTGATGAGACGCTTGAGTGTTGAAA
GGCTCACAAAGAGCTCTTCAGCTAATTCTTCCAAAGAGTTGAAGTCTCTGAAAAAAAGGGTCTCCAGTAA
TTTAAATGATTGAGAGTGTCTCAGAGCTTTCTGATAGACTTCTTGCAAACCGCAATGTTGATGGTACCAG
ATTGTAATATAACCATTTTTATAGGTAATTCCTCCCACTTCCTTCATAAATTGCATGTTAGTGAGACAAG
TTTGCAATGTTAACATGGAGATGTTGAGAGCTTTGCTGAGTTCTTTATCTTTGACGCCAATGGCGTCAGC
GTTTTCTGTTACGTATGAGATTAATTTTAGTTCTCTCCACTGTTGACTTGTAAACAACTTACTTACATAC
A
Protein Sequence 
>gi|21911264|ref|NP_665532.1| M protein trans-acting positive regulator, multi-gene activator [Streptococcus pyogenes MGAS315] MYVSKLFTSQQWRELKLISYVTENADAIGVKDKELSKALNISMLTLQTCLTNMQFMKEVGGITYKNGYITIWYHQHCGLQEVYQKALRHSQSFKLLETLFFRDFNSLEELAEELFVSLSTLKRLIKKTNAYLMHTFGITILTSPVQVSGDEHQIRLFYLKYFSEAYKISEWPFGEILNLKNCERLLSLMIKEVDVRVNFTLFQHLKILSSVNLIRYYKGHSAVYDNKKTSHRFSQLIQSSLEIQDLSRLFYLKFGLYLDETTIAEMFSNHVNDQLEIGYAFDSIKQDSPTGCRKVTNWVHLTNWVHLLDELEIRLNLSVTNKYEVAVILHNTTVLKEEDITANYLFFDYKKSYLNFYKQEHPHLYKAFVAGVEKLMRSEKEPISTELTNQLIYAFFITWENSFLEVNQKDEKIRLLVIERSFNSVGNFLKKYIGEFFSITNFNELDALTIDLEEIEKQYDVIVTDVMVGKSDELEIFFFYKMIPEAIIDKLNAFLNISSADSLPLDKPIKNPLDFHRKEVIFPTPPNKLHAPPSTS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008).
References
Luo et al., 2008: Luo F, Lizano S, Banik S, Zhang H, Bessen DE. Role of Mga in group A streptococcal infection at the skin epithelium. Microbial pathogenesis. 2008; 45(3); 217-224. [PubMed: 18588968].