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SpyM3_0104

Victor ID 4323
Gene Name SpyM3_0104
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS315
NCBI Gene ID 1008418
NCBI Protein GI 21909640
Locus Tag SpyM3_0104
Genbank Accession AE014074
Protein Accession NP_663908
Other Database IDs UniProtKB-ID: Q8K8U1_STRP3
UniRef100: UniRef100_Q8K8U1
UniRef90: UniRef90_Q8K8U1
UniRef50: UniRef50_A2RC81
UniParc: UPI00000DA984
EMBL: AE014074
EMBL-CDS: AAM78711.1
RefSeq_NT: NC_004070.1
EnsemblGenome: EBSTRG00000034478.
EnsemblGenome_TRS: EBSTRT00000034478
EnsemblGenome_PRO: EBSTRP00000033217
GenomeReviews: AE014074_GR
KEGG: spg:SpyM3_0104
HOGENOM: HBG697993
OMA: YEVATAI
ProtClustDB: CLSK634222
BioCyc: SPYO198466:SPYM3_0104-MONOMER
Taxonomy ID 198466
Gene Starting Position 124969
Gene Ending Position 126939
Gene Strand (Orientation) +
Protein Name protein F2 like fibronectin-binding protein
Protein pI 4.3
Protein Weight 67623.12
Protein Length 656
Protein Note best blastp hit: gb|AAL11472.1| (AY049089) fibronectin binding protein [Streptococcus pyogenes]
DNA Sequence 
>gi|21909536:124969-126939 Streptococcus pyogenes MGAS315 chromosome, complete genome
ATTGAGTAGTAGTGATGAAGAAACACTAAAGCAATATGCCTCTAAATATACAAGTAATAGGAGAGGAGAT
ACTAGTGGTAATCTTAAAAAGCAAATTGCTAAGGTTCTGACAGAAGGTTACCCAACTAACAAAAGTGATT
GGTTAAATGGATTGACTGAAAACGAAAAAATAGAAGTAACCCAGGATGCAATTTGGTATTTTACAGAAAC
GACAGTTCCGGCTGATAGAAGTTATACGAATCGCAACGTAAATAGTCAAAAAATGAAAGAAGTGTATCAA
AAGCTAATTGATACAACAGATATAGATAAATATGAAGATGTACAATTTGATTTATTTGTGCCACAAGATA
CAAACTTACAGGCAGTAATTAGTGTAGAGCCTGTTATCGAAAGCCTTCCTTGGACATCGTTGAAGCCAAT
AGCCCAGAAGGATATCACTGCAAAAAAAATCTGGGTAGATGCACCTAAAGAAAAACCAATTATTTATTTT
AAGCTATATAGACAGCTGCCTGGAGAAAAGGAAGTAGCAGTGGATGACGCTGAGCTAAAACAGATAAATA
GTGAAGGTCAACAAGAAATATCAGTAACTTGGACAAATCAACTTGTTACAGATGAAAAAGGAATGGCTTA
TATTTATTCTGTAAAAGAAGTAGATAAAAATGGCGAGTTACTTGAGCCAAAAGATTATATCAAGAAGGAA
GATGGACTTACAGTTACTAATACTTATGTAAAGCCAACTAGTGGGCACTATGATATAGAAGTGACATTTG
GAAATGGACATATTGATATTACAGAAGATACTACACCAGATATTGTTTCAGGTGAAAACCAAATGAAGCA
AATAGAGGGAGAAGATAGTAAGCCTATTGATGAAGTAACGGAAAATAATTTAATTGAATTTGGTAAAAAC
ACGATGCCAGGTGAAGAAGATGGCACAAATTCTAATAAGTATGAAGAAGTCGAAGACTCACGCCCAGTTG
ATACCTTATCAGGTTTATCAAGTGAGCAAGGTCAGTCCGGTGATATGACAATTGAAGAAGATAGTGCTAC
CCATATTAAATTCTCAAAACGTGATATTGACGGCAAAGAGTTAGCTGGTGCAACTATGGAGTTGCGTGAT
TCATCTGGTAAAACTATTAGTACATGGATTTCAGATGGACAAGTGAAAGATTTCTACCTGATGCCAGGAA
AATATACATTTGTCGAAACCGCAGCACCAGACGGTTATGAGGTAGCAACTGCTATTACCTTTACAGTTAA
TGAGCAAGGTCAGGTTACTGTAAATGGCAAAGCAACTAAAGGTGACGCTCATATTGTCATGGTTGATGCT
TACAAGCCAACTAAGGGTTCAGGTCAGGTTATTGATATTGAAGAAAAGCTTCCAGACGAGCAAGGCCATT
CTGGCTCAACTACTGAAATAGAAGACAGTAAATCTTCAGACGTTATCATTGGCGGTCAAGGTGAAGTTGT
TGACACAACAGAAGACACACAAAGTGGTATGACAGGCCATTCTGGCTCAACTACTGAAATAGAAGACAGT
AAATCTTCAGACGTTATCATTGGCGGTCAAGGTGAAGTTGTTGACACAACAGAAGACACACAAAGTGGTA
TGACAGGCCATTCTGGCTCAACTACTAAAATAGAAGATAGCAAGTCTTCAGACGTTATCGTTGGTGGTCA
GGGGCAGATTGTCGAGACAACAGAGGATACCCAAACTGGCATGCACGGAGATTCTGGTCGTAAAACGGAA
GTCGAAGATACTAAACTAGTACAATCCTTCCACTTTGATAACAAGGAACCAGAAAGTAACTCTGAGATTC
CTAAAAAAGATAAGTCAAAGAGTAATACTAGTTTACCAGCAACTGGTGAGAAGCAACATAACAAGTTCTT
TTGGATGGTTACTTCTTGCTCACTTATTAGTAGTGTTTTTGTAATATCACTAAAATCCAAAAAACGCCTA
TCATCATGTTA
Protein Sequence 
>gi|21909640|ref|NP_663908.1| protein F2 like fibronectin-binding protein [Streptococcus pyogenes MGAS315]
MSSSDEETLKQYASKYTSNRRGDTSGNLKKQIAKVLTEGYPTNKSDWLNGLTENEKIEVTQDAIWYFTET
TVPADRSYTNRNVNSQKMKEVYQKLIDTTDIDKYEDVQFDLFVPQDTNLQAVISVEPVIESLPWTSLKPI
AQKDITAKKIWVDAPKEKPIIYFKLYRQLPGEKEVAVDDAELKQINSEGQQEISVTWTNQLVTDEKGMAY
IYSVKEVDKNGELLEPKDYIKKEDGLTVTNTYVKPTSGHYDIEVTFGNGHIDITEDTTPDIVSGENQMKQ
IEGEDSKPIDEVTENNLIEFGKNTMPGEEDGTNSNKYEEVEDSRPVDTLSGLSSEQGQSGDMTIEEDSAT
HIKFSKRDIDGKELAGATMELRDSSGKTISTWISDGQVKDFYLMPGKYTFVETAAPDGYEVATAITFTVN
EQGQVTVNGKATKGDAHIVMVDAYKPTKGSGQVIDIEEKLPDEQGHSGSTTEIEDSKSSDVIIGGQGEVV
DTTEDTQSGMTGHSGSTTEIEDSKSSDVIIGGQGEVVDTTEDTQSGMTGHSGSTTKIEDSKSSDVIVGGQ
GQIVETTEDTQTGMHGDSGRKTEVEDTKLVQSFHFDNKEPESNSEIPKKDKSKSNTSLPATGEKQHNKFF
WMVTSCSLISSVFVISLKSKKRLSSC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: F2 like fibronectin-binding protein mutant had attenuated attachment to to HEp-2 epithelial cells (Kreikemeyer et al., 2004).
COG COG4932M, under M: Cell wall/membrane/envelope biogenesis
References
Kreikemeyer et al., 2004: Kreikemeyer B, Oehmcke S, Nakata M, Hoffrogge R, Podbielski A. Streptococcus pyogenes fibronectin-binding protein F2: expression profile, binding characteristics, and impact on eukaryotic cell interactions. The Journal of biological chemistry. 2004; 279(16); 15850-15859. [PubMed: 14749329].