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lsp from Streptococcus pyogenes str. Manfredo

Victor ID 4429
Gene Name lsp from Streptococcus pyogenes str. Manfredo
Sequence Strain (Species/Organism) Streptococcus pyogenes str. Manfredo
NCBI Gene ID 4963525
NCBI Protein GI 139473996
Locus Tag SpyM51170
Protein Accession YP_001128712.1
Other Database IDs UniProtKB-ID: LSPA_STRPG
UniRef100: UniRef100_A2RF66
UniRef90: UniRef90_Q1JCF3
UniRef50: UniRef50_Q5M0X5
UniParc: UPI00000D98B5
EMBL: AM295007
EMBL-CDS: CAM30495.1
RefSeq_NT: NC_009332.1
EnsemblGenome: EBSTRG00000047481
EnsemblGenome_TRS: EBSTRT00000047489
EnsemblGenome_PRO: EBSTRP00000045617
GenomeReviews: AM295007_GR
KEGG: spf:SpyM51170
eggNOG: COG0597
HOGENOM: HBG724422
OMA: ADSSGWQ
ProtClustDB: PRK14797
Taxonomy ID 160491
Gene Starting Position 1170429
Gene Ending Position 1170887
Gene Strand (Orientation) -
Protein Name lipoprotein signal peptidase
DNA Sequence 
>gi|139472888:1170429-1170887 Streptococcus pyogenes str. Manfredo, complete genome
ATTAATTTCCATAATCCTCTTCTTTCCATAAACATATCACTAACAATATGACCCCAACGGTAAGGTATGA
ATCTGCCACATTAAAAATGGCAAAATCCACAAAGTCTAAATGAATCATATCAATCACGTAAGCTAAACGC
AAACGATCAATAAAATTCCCGATTCCACCAGAAATAATAAGCAAGAGAGCTAATTGCTTCCAGATATTTA
AATGGGGATGAGTAGCAAGGTAATAAATAGCATAACCGATAACTAAAACCGTTATGACAACAAAGAACCA
TTGCTGGTCCTGCAATATGGAAAAGGCAGCCCCATTGTTTTGCAAGTAAGTCAAGCTGACGATACCTGGG
ATAAAGGGTTTCACTTCTCCAAGCGCTATATGAGAAACAATCCAAAATTTACTAAGTTGATCCAAAGCTA
CAAGGAGGATCAAGCTAAGCACAAACAATCGTTTTTTCA
Protein Sequence 
>gi|139473996|ref|YP_001128712.1| lipoprotein signal peptidase [Streptococcus pyogenes str. Manfredo] MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMIHLDFVDFAIFNVADSYLTVGVILLVICLWKEEDYGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weston et al., 2009: Weston BF, Brenot A, Caparon MG. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity. 2009; 77(7); 2840-2848. [PubMed: 19398546].