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fba from Streptococcus pyogenes MGAS10270

Victor ID 4393
Gene Name fba from Streptococcus pyogenes MGAS10270
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS10270
NCBI Gene ID 4064175
NCBI Protein GI 94991185
Locus Tag MGAS10270_Spy1676
Protein Accession YP_599285.1
Other Database IDs UniProtKB-ID: Q1JF18_STRPD
UniRef100: UniRef100_P68905
UniRef90: UniRef90_P68905
UniRef50: UniRef50_P0A4S2
UniParc: UPI0000165A3F
EMBL: CP000260
EMBL-CDS: ABF34741.1
RefSeq_NT: NC_008022.1
EnsemblGenome: EBSTRG00000040450.
EnsemblGenome_TRS: EBSTRT00000040453
EnsemblGenome_PRO: EBSTRP00000038937
GenomeReviews: CP000260_GR
KEGG: sph:MGAS10270_Spy1676
eggNOG: COG0191
HOGENOM: HBG327581
OMA: EYEANEA
ProtClustDB: PRK07315
BioCyc: SPYO370552:MGAS10270_SPY1676-MONOMER
Taxonomy ID 370552
Gene Starting Position 1619448
Gene Ending Position 1620329
Gene Strand (Orientation) -
Protein Name fructose-bisphosphate aldolase
DNA Sequence 
>gi|94989509:1619448-1620329 Streptococcus pyogenes MGAS10270 chromosome, complete genome
ATTATGCTTTGTTAGCTGATCCGAAAACATCGATACGTTCTTCAACAGCACCTTGAACAGCTTTCATACC
TGGAGCCAAGAATTTACGTGGGTCAAATAATTTTTTACCATCATATTCTGCTTCGTTAGCTTCGTAGTTA
CGAGCAAATTCACGAGTTGCGTTAGAGAAAGCGATTTGACTTTCAGTGTTAACGTTAACTTTAGCAACAC
CAAGACGGATTGCTTCTTTGATTTGATCGTCAGGAATACCAGAACCACCGTGCAATACGATTGGGAAACC
TGGTACAGCTGCTGTTAATTTTTCTAAGTGGTCAAGAGCAAGACCTTCCCAGTTTTCTGGGTATGGACCG
TGGATGTTACCGATACCAGCTGCCAAGAAGTCAATTCCAGTTTCAACCATTGCTTTAGCATCCTCGATTG
GAGCGAGCTCACCTTTACCGATGATACCGTCTTCTTCACCACCGATTGTACCAACTTCAGCTTCAACTGA
AACGCCTTTAGCATGTGCAATTTTAACAACTTCTGCAGTTTTAGCAAGGTTTTCTTCAACTGGAAGGTGT
GAACCGTCAAACATGATTGAAGTGTAACCTACTTCGATACACTCAAGAGCATCTTCGTAGTGACCATGAT
CAAGGTGGATAGCAACAGGAACAGTGATACCCATTGACTCAACAAGGTTAGTAATAAGAGATTGACATAC
TTTATAACCACCCATGTATTTTGCTGCACCCATTGATGTTTGGATAAGAACTGGAGCTTGTTTAGCTTCT
GCTGCACGCAAGATTGCTTGAGTCCACTCTAAGTTGTTTGTGTTAAATCCACCAACAGCATATCCGTTTT
CACGAGCTGCTTGGACAAATTTTTCTGCTGAAACGATTGCCA
Protein Sequence 
>gi|94991185|ref|YP_599285.1| Fructose-bisphosphate aldolase [Streptococcus pyogenes MGAS10270] MAIVSAEKFVQAARENGYAVGGFNTNNLEWTQAILRAAEAKQAPVLIQTSMGAAKYMGGYKVCQSLITNLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLAKTAEVVKIAHAKGVSVEAEVGTIGGEEDGIIGKGELAPIEDAKAMVETGIDFLAAGIGNIHGPYPENWEGLALDHLEKLTAAVPGFPIVLHGGSGIPDDQIKEAIRLGVAKVNVNTESQIAFSNATREFARNYEANEAEYDGKKLFDPRKFLAPGMKAVQGAVEERIDVFGSANKA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection (Terao et al., 2001).
COG COG0191G, under G: Carbohydrate transport and metabolism
References
Terao et al., 2001: Terao Y, Kawabata S, Kunitomo E, Murakami J, Nakagawa I, Hamada S. Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator. Molecular microbiology. 2001; 42(1); 75-86. [PubMed: 11679068].