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perR

Victor ID 4369
Gene Name perR
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3572745
NCBI Protein GI 71909975
Locus Tag M5005_Spy_0161
Protein Accession YP_281525.1
Other Database IDs UniProtKB-ID: Q491D8_STRP1
UniRef100: UniRef100_Q1JDT4
UniRef90: UniRef90_B4U0B9
UniRef50: UniRef50_D3HGC8
UniParc: UPI00000B3C62
EMBL: CP000017
EMBL-CDS: AAZ50780.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000027585.
EnsemblGenome_TRS: EBSTRT00000027585
EnsemblGenome_PRO: EBSTRP00000026603
GenomeReviews: CP000017_GR
KEGG: spz:M5005_Spy_0161
HOGENOM: HBG731501
OMA: PTADWVY
ProtClustDB: CLSK877007
BioCyc: SPYO293653:M5005_SPY0161-MONOMER
Taxonomy ID 293653
Gene Starting Position 175469
Gene Ending Position 175936
Gene Strand (Orientation) +
Protein Name ferric uptake regulation protein
DNA Sequence 
>gi|71909814:175469-175936 Streptococcus pyogenes MGAS5005 chromosome, complete genome
TATGGACATTCATTCACATCAGCAAGCCCTAGATGCCTATGAAAATGTCCTAGAGCATCTACGGGAAAAA
CATATTCGAATTACAGAGACACGTAAAGCCATTATTTCTTACATGATTCAGTCCACAGAACACCCTAGTG
CCGATAAGATTTACCGTGACTTACAGCCTAACTTTCCTAACATGAGCCTTGCCACAGTCTATAATAATTT
GAAAGTTTTAGTTGATGAAGGTTTTGTCTCAGAGTTGAAAATCAGCAATGATTTAACCACCTACTATGAC
TTTATGGGCCATCAACACGTCAATGTAGTTTGTGAAATATGTGGGAAGATTGCTGACTTTATGGATGTTG
ATGTTATGGATATTGCCAAAGAAGCCCATGAGCAAACAGGTTATAAGGTCACGCGTATCCCAGTTATTGC
TTACGGGATTTGTCCGGATTGCCAAGCAAAAGACCAATCTGATTTTTA
Protein Sequence 
>gi|71909975|ref|YP_281525.1| ferric uptake regulation protein [Streptococcus pyogenes MGAS5005] MDIHSHQQALDAYENVLEHLREKHIRITETRKAIISYMIQSTEHPSADKIYRDLQPNFPNMSLATVYNNLKVLVDEGFVSELKISNDLTTYYDFMGHQHVNVVCEICGKIADFMDVDVMDIAKEAHEQTGYKVTRIPVIAYGICPDCQAKDQSDF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: perR mutant is attenuated in mouse air sac model (Ricci et al., 2002).
COG COG0735P, under P: Inorganic ion transport and metabolism
References
Ricci et al., 2002: Ricci S, Janulczyk R, Björck L. The regulator PerR is involved in oxidative stress response and iron homeostasis and is necessary for full virulence of Streptococcus pyogenes. Infection and immunity. 2002; 70(9); 4968-4976. [PubMed: 12183543].