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sic

Victor ID 4278
Gene Name sic
Sequence Strain (Species/Organism) Streptococcus pyogenes M1 GAS
NCBI Gene ID 901676
NCBI Protein GI 15675798
Locus Tag SPy_2016
Protein Accession NP_269972.1
Other Database IDs UniProtKB-ID: Q7DAL1_STRP1
UniRef100: UniRef100_Q9JNH0
UniRef90: UniRef90_Q9JNG5
UniRef50: UniRef50_Q9JNB6
UniParc: UPI00000C6EB4
EMBL: AE004092
EMBL-CDS: AAK34693.1
RefSeq_NT: NC_002737.1
EnsemblGenome: EBSTRG00000001205.
EnsemblGenome_TRS: EBSTRT00000001205
EnsemblGenome_PRO: EBSTRP00000001205
GenomeReviews: AE004092_GR
KEGG: spy:SPy_2016
HOGENOM: HBG219669
ProtClustDB: CLSK443223
BioCyc: SPYO160490:SPY2016-MONOMER
Taxonomy ID 160490
Gene Starting Position 1682671
Gene Ending Position 1683597
Gene Strand (Orientation) -
Protein Name inhibitor of complement-mediated lysis
DNA Sequence 
>gi|15674250:1682671-1683597 Streptococcus pyogenes M1 GAS chromosome, complete genome
TTTACGTTGCTGATGGTGTATATGGTGTACCGAAGGCTTGCATGTAACCTTTTTTATATTCGTCTGACCA
GCCACCATACTGGAAACCTTCAAAATCAATACCTCTACCTGAGTTTTTTGCTTTCAAGCCAGCTGAAAAC
CCTCTATCAAAATCTGATTCTTGTGGATTTTTTTGAGGAGTATGTTGCGGTTTTTCTGGCACACGAGGTT
CACTTGGAGGGGTGTCCTCAGATTGGCCCCAATCAGAGGGGCCAAATGATAATCCATCAAAGCCATTCCA
CTGAGGCCACTCAATCTGAGGAGGTTCAGGAATATGAAGTGGGTTTGGTGATTGTTCGTTCTCAGGTTTA
GGAATATGTCCAGGTCCTCTCCAATCATCACGTTTTTCATACCCTGTACCTAATGCTCCTCCATATGGTG
GAGTGTAAGGGTCAGTTGCCACCGTACCAGGTCCTCCCCAATCATCACGTTTTTCATACCCTGTACCTAA
TGCTCCTCCATATGGTGGAGTGTAAGGGTCAGTTGCCACCGTACCAGGTCCTCCCCAATCATCACGTTTT
TCATACCCTGTACCTAATGCTTCTCCATATGGTGGTCTCGTTTTATCTTCTGTCTCATCTTTTTTATCGC
TAGACCAGTCATCTTCAGGCCAATCTTCAGGCCATTCTTCTTTATCGCTAGACCAGCCATATTTAGACCA
GCCATATTGAGACAAACCAACTCCAGACCGGTCATATTTAGACAAACCATCTCCAGACCAGTCATCTTCA
GGCCAGTCATCTCCAGACCAGTCATCTCCAGACCAGTCAAAATTGCGTGATGTATACGTTTCGGCTGAAA
CTGGTTGTGTAGCTCCTAGTAGAGCCACGGCTACAAGGGATGTAAATAGTAGTGTTTTACTATTTTCAAT
CTTATTTCTAATATTCA
Protein Sequence 
>gi|15675798|ref|NP_269972.1| inhibitor of complement-mediated lysis [Streptococcus pyogenes M1 GAS] MNIRNKIENSKTLLFTSLVAVALLGATQPVSAETYTSRNFDWSGDDWSGDDWPEDDWSGDGLSKYDRSGVGLSQYGWSKYGWSSDKEEWPEDWPEDDWSSDKKDETEDKTRPPYGEALGTGYEKRDDWGGPGTVATDPYTPPYGGALGTGYEKRDDWGGPGTVATDPYTPPYGGALGTGYEKRDDWRGPGHIPKPENEQSPNPLHIPEPPQIEWPQWNGFDGLSFGPSDWGQSEDTPPSEPRVPEKPQHTPQKNPQESDFDRGFSAGLKAKNSGRGIDFEGFQYGGWSDEYKKGYMQAFGTPYTPSAT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sic mutant was phagocytosed and killed by human polymorphonuclear leukocytes significantly better than the wild-type strain (Hoe et al., 2002).
References
Hoe et al., 2002: Hoe NP, Ireland RM, DeLeo FR, Gowen BB, Dorward DW, Voyich JM, Liu M, Burns EH Jr, Culnan DM, Bretscher A, Musser JM. Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(11); 7646-7651. [PubMed: 12032337].