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lsp from Streptococcus pyogenes MGAS10750

Victor ID 4398
Gene Name lsp from Streptococcus pyogenes MGAS10750
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS10750
NCBI Gene ID 4067861
NCBI Protein GI 94994122
Locus Tag MGAS10750_Spy0726
Protein Accession YP_602220.1
Other Database IDs UniProtKB-ID: LSPA_STRPF
UniRef100: UniRef100_Q1JCF3
UniRef90: UniRef90_Q1JCF3
UniRef50: UniRef50_Q5M0X5
UniParc: UPI000000AF69
EMBL: CP000262
EMBL-CDS: ABF37676.1
RefSeq_NT: NC_008024.1
EnsemblGenome: EBSTRG00000042664
EnsemblGenome_TRS: EBSTRT00000042669
EnsemblGenome_PRO: EBSTRP00000041064
GenomeReviews: CP000262_GR
KEGG: spi:MGAS10750_Spy0726
eggNOG: COG0597
HOGENOM: HBG724422
OMA: ADSSGWQ
ProtClustDB: PRK14797
BioCyc: SPYO370554:MGAS10750_SPY0726-MONOMER
Taxonomy ID 370554
Gene Starting Position 700972
Gene Ending Position 701430
Gene Strand (Orientation) +
Protein Name lipoprotein signal peptidase
DNA Sequence 
>gi|94993396:700972-701430 Streptococcus pyogenes MGAS10750 chromosome, complete genome
CATGAAAAAACGATTGTTTGTGCTTAGCTTGATCCTCCTTGTAGCTTTGGATCAACTTAGTAAATTTTGG
ATTGTTTCTCATATAGCGCTTGGAGAAGTGAAACCCTTTATCCCAGGTATCGTCAGCTTGACTTACTTGC
AAAACAATGGGGCTGCCTTTTCCATATTGCAGGACCAGCAATGGTTCTTTGTTGTCATAACGGTTTTAGT
TATCGGTTATGCTATTTATTACCTTGCTACTCATCCCCATTTAAATATCTGGAAACAATTAGCTCTCTTG
CTTATTATTTCTGGTGGAATCGGGAATTTTATTGATCGTTTGCGTTTAGCTTACGTGATTGATATGGTTC
ATTTAGACTTTGTGGATTTTGCCATTTTTAATGTGGCAGATTCATACCTTACCGTTGGTGTCATATTATT
AGTGATATGTTTATGGAAAGAAGAGGATTATGGAAATTA
Protein Sequence 
>gi|94994122|ref|YP_602220.1| lipoprotein signal peptidase [Streptococcus pyogenes MGAS10750] MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMVHLDFVDFAIFNVADSYLTVGVILLVICLWKEEDYGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weston et al., 2009: Weston BF, Brenot A, Caparon MG. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity. 2009; 77(7); 2840-2848. [PubMed: 19398546].