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slo

Victor ID 4324
Gene Name slo
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS315
NCBI Gene ID 1008444
NCBI Protein GI 21909666
Locus Tag SpyM3_0130
Protein Accession NP_663934.1
Other Database IDs UniProtKB-ID: TACY_STRP3
UniRef100: UniRef100_P0C0I3
UniRef90: UniRef90_Q53957
UniRef50: UniRef50_Q54114
UniParc: UPI0000136874
EMBL: M18638
EMBL: AE014074
EMBL: BA000034
EMBL-CDS: AAA26975.1
EMBL-CDS: AAM78737.1
EMBL-CDS: BAC63227.1
RefSeq_NT: NC_004070.1
RefSeq_NT: NC_004606.1
EnsemblGenome: EBSTRG00000033538
EnsemblGenome_TRS: EBSTRT00000033538
EnsemblGenome_PRO: EBSTRP00000032277
EnsemblGenome: EBSTRG00000036637
EnsemblGenome_TRS: EBSTRT00000036637
EnsemblGenome_PRO: EBSTRP00000035287
Genome
Taxonomy ID 198466
Gene Starting Position 153250
Gene Ending Position 154965
Gene Strand (Orientation) +
Protein Name streptolysin O
DNA Sequence 
>gi|21909536:153250-154965 Streptococcus pyogenes MGAS315 chromosome, complete genome
CATGTCTAATAAAAAAACATTTAAAAAATACAGTCGCGTCGCTGGGCTACTGACGGCAGCTCTTATCATT
GGTAACCTTGTTACTGCTAATGCTGAATCGAACAAACAAAACACTGCTAGTACAGAAACCACAACGACAA
ATGAGCAACCAAAGCCAGAAAGTAGTGAGCTAACTACTGAAAAAGCAGGTCAGAAAACGGATGATATGCT
TAACTCTAACGATATGATTAAGCTTGCTCCCAAAGAAATGCCACTAGAATCTGCAGAAAAAGAAGAAAAA
AAGTCAGAAGACAAAAAAAAGAGCGAAGAAGATCACACTGAAGAAATCAATGACAAGATTTATTCACTAA
ATTATAATGAGCTTGAAGTACTTGCTAAAAATGGTGAAACCATTGAAAATTTTGTTCCTAAAGAAGGCGT
TAAGAAAGCTGATAAATTTATTGTCATTGAAAGAAAGAAAAAAAATATCAACACTACACCAGTCGATATT
TCCATCATTGACTCTGTCACTGATAGGACCTATCCAGCAGCCCTTCAGCTGGCTAATAAAGGTTTTACCG
AAAACAAACCAGACGCGGTAGTCACCAAGCGAAACCCACAAAAAATCCATATTGATTTACCAGGTATGGG
AGACAAAGCAACGGTTGAGGTCAATGACCCTACCTATGCCAATGTTTCAACAGCTATTGATAATCTTGTT
AACCAATGGCATGATAATTATTCTGGTGGTAATACGCTTCCTGCCAGAACACAATATACTGAATCAATGG
TATATTCTAAGTCACAGATTGAAGCAGCTCTAAATGTTAATAGCAAAATCTTAGATGGTACTTTAGGCAT
TGATTTCAAGTCGATTTCAAAAGGTGAAAAGAAGGTGATGATTGCAGCATACAAGCAAATTTTTTACACC
GTATCAGCAAACCTTCCTAATAATCCTGCGGATGTGTTTGATAAATCAGTGACCTTTAAAGAGTTGCAAC
GAAAAGGTGTCAGCAATGAAGCTCCGCCACTCTTTGTGAGTAACGTAGCCTATGGTCGAACTGTTTTTGT
CAAACTAGAAACAAGTTCTAAAAGTAATGATGTTGAAGCGGCCTTTAGTGCAGCTCTAAAAGGAACAGAT
GTTAAAACTAATGGAAAATACTCTGATATCTTAGAAAATAGCTCATTTACAGCTGTCGTTTTAGGAGGAG
ATGCTGCAGAGCACAATAAGGTAGTCACAAAAGACTTTGATGTTATTAGAAACGTTATCAAAGACAATGC
TACCTTCAGTAGAAAAAACCCAGCTTATCCTATTTCATACACCAGTGTTTTCCTTAAAAATAATAAAATT
GCGGGTGTCAATAACAGAACTGAATACGTTGAAACAACATCTACCGAGTACACTAGTGGAAAAATTAACC
TGTCTCATCAAGGCGCGTATGTTGCTCAATATGAAATCCTTTGGGATGAAATCAATTATGATGACAAAGG
AAAAGAAGTGATTACAAAACGACGTTGGGATAACAACTGGTATAGTAAGACATCACCATTTAGCACAGTT
ATCCCACTAGGAGCTAATTCACGAAATATACGTATCATGGCTAGAGAGTGCACCGGCTTAGCTTGGGAAT
GGTGGCGAAAAGTGATCGACGAAAGAGATGTGAAACTGTCTAAAGAAATCAATGTCAACATCTCAGGATC
AACCCTGAGCCCATATGGTTCGATTACTTATAAGTA
Protein Sequence 
>gi|21909666|ref|NP_663934.1| streptolysin O [Streptococcus pyogenes MGAS315] MSNKKTFKKYSRVAGLLTAALIIGNLVTANAESNKQNTASTETTTTNEQPKPESSELTTEKAGQKTDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDKKKSEEDHTEEINDKIYSLNYNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAALQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDKATVEVNDPTYANVSTAIDNLVNQWHDNYSGGNTLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIAAYKQIFYTVSANLPNNPADVFDKSVTFKELQRKGVSNEAPPLFVSNVAYGRTVFVKLETSSKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGGDAAEHNKVVTKDFDVIRNVIKDNATFSRKNPAYPISYTSVFLKNNKIAGVNNRTEYVETTSTEYTSGKINLSHQGAYVAQYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: slo mutant was attenuated in mice (Limbago et al., 2000).
References
Limbago et al., 2000: Limbago B, Penumalli V, Weinrick B, Scott JR. Role of streptolysin O in a mouse model of invasive group A streptococcal disease. Infection and immunity. 2000; 68(11); 6384-6390. [PubMed: 11035749].