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mga from Streptococcus pyogenes MGAS6180

Victor ID 4352
Gene Name mga from Streptococcus pyogenes MGAS6180
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS6180
NCBI Gene ID 3574433
NCBI Protein GI 71904366
Locus Tag M28_Spy1704
Protein Accession YP_281169.1
Other Database IDs UniProtKB-ID: Q48R46_STRPM
UniRef100: UniRef100_Q48R46
UniRef90: UniRef90_Q1J4H5
UniRef50: UniRef50_P19401
UniParc: UPI000057BF7C
EMBL: CP000056
EMBL-CDS: AAX72814.1
RefSeq_NT: NC_007296.1
EnsemblGenome: EBSTRG00000032579.
EnsemblGenome_TRS: EBSTRT00000032579
EnsemblGenome_PRO: EBSTRP00000031411
GenomeReviews: CP000056_GR
KEGG: spb:M28_Spy1704
HOGENOM: HBG698420
OMA: NWIHLLD
ProtClustDB: CLSK443224
BioCyc: SPYO319701:M28_SPY1704-MONOMER
Taxonomy ID 319701
Gene Starting Position 1713652
Gene Ending Position 1715268
Gene Strand (Orientation) -
Protein Name M protein trans-acting positive regulator (Mga)
DNA Sequence 
>gi|71902667:1713652-1715268 Streptococcus pyogenes MGAS6180 chromosome, complete genome
CCTATGATGATGTTGCTGATGTTGCTTGTTTAACAGAATTGTCTGGCTTTTCTGGCTTTTGTACCTCTTT
GTCGCTATGAGATTTTGAAGGAGAAGGGGCTTCGAGGTTTTTGACCATAACATTGTTATCTGTGAAACTA
ACGTTCAAAAATTCGTTTAATCTATCAATAATAGCTTCTGGGATCATCTTGTAGAAAAAGAAAATCTCTA
ACTCTTCGCTTTTACCCACCATAACATCTGTCACGATAACATCGTACTGTTTTTCAATCTCTACTAGATC
AATTGTCAGACAATCTAACTCATCAAAATTAGTAATGCTGAAAAACTCACCGATGTACTTTTTCAAAAAA
TTACCGACACTATTGTAACTTCTCTCTATCACTAGGAGTCGTACTTTTTCTTTTTGATTTACTTTTAAGA
AACTATTTTCCCAGGTAATAAAGAAACAATAAGTGAGCTGATTGATCAATTCTTTGCTAACTTGAGCATT
ATCTGCCTGCATCAGCTTCTCGACACTTGTCACAAAGGCCTCATAGATACGAGGGTGTTCTTTTTGGTAA
AAGTTCAGGTAACTCTTTTTATAATCAAACAGCAAATAATTGGCTGTAATGTCTTCTTCGTTTAACACCG
AAGCGTTATGGAGGGTTACGGCAACTTCGTATTTATTGGTGATGCTGAGATTGAGCTTGATTTCCATCTC
ATCTAATAGATGGATCCAGTTGGTTACTTGTCTGCCTCCTGATATTGGGTCTTGATTGATAATCTCAAAA
GCACAGCCAATTTCTAGCTTGTCGTTAAGATGGTTAGAAAACATTTCAGCTATGGTATACTCGTCGAGAT
GTAACCCAAATTTGAGGTAGAACAAGCGAGAAAGATCCTGGATTTCTGAGGAATGTTGGATAAGTTGAGA
AAAACGGTGACTGGTTTTTTTATTGTTATAACTGCAAGAATACCCCTTGTAGTAACGGATCAAGTTGACG
CCACTTAAGATTTTTAAGTGCTGAAATAGCGTAAAATGAACTTTGACATCTACTTCTTTGATCAATAAGC
TCAATAGGCGTTCACAGTTTTTCAGGTTTAAAATGTCCCCAAATGGCCATTCTGAGATTTTATAGGCTTC
TGAAAAATACTTGAGGTAAAACAGGCGAATTTGCCTCTCATCTCCTGACACCTGCACTGGACTTGTCACG
ATACTAATAGCAAAGGTATGAGACAAGTAAGTGTTGGTTTTTTTGATGAGGCGTTTGAGGGTAGATAAGC
TGACAAACAGCTCTTCAGCTAACTCTTCTAAGGAACTAAAGTCTCTGAAAAACAAAAGCTCCAGTAATTT
CAAAGAAGGCGATTCTCGAAGAGCTTTTTGATAGACCTCTTGTAGCCCACAACACTGGTGATACCAAATG
TTAATATAGCCGTCTTTGTAGGTAATTCCACCTACTTCTTTCATAAACTGCATATTAGTGAGGCATGACT
GTAATGTTAACATGGAAATATTGAGAGCCTTGCTAAGCTCCTTATCTTTAACTCCGATAGCATTGGAGTT
TTCTGTTAAATATGAGATCAGTTTCAATTCTCTCCATTGTTGGCTAGTAAACAATTTACTTACATGCATT
AACTTCA
Protein Sequence 
>gi|71904366|ref|YP_281169.1| M protein trans-acting positive regulator (Mga) [Streptococcus pyogenes MGAS6180] MKLMHVSKLFTSQQWRELKLISYLTENSNAIGVKDKELSKALNISMLTLQSCLTNMQFMKEVGGITYKDGYINIWYHQCCGLQEVYQKALRESPSLKLLELLFFRDFSSLEELAEELFVSLSTLKRLIKKTNTYLSHTFAISIVTSPVQVSGDERQIRLFYLKYFSEAYKISEWPFGDILNLKNCERLLSLLIKEVDVKVHFTLFQHLKILSGVNLIRYYKGYSCSYNNKKTSHRFSQLIQHSSEIQDLSRLFYLKFGLHLDEYTIAEMFSNHLNDKLEIGCAFEIINQDPISGGRQVTNWIHLLDEMEIKLNLSITNKYEVAVTLHNASVLNEEDITANYLLFDYKKSYLNFYQKEHPRIYEAFVTSVEKLMQADNAQVSKELINQLTYCFFITWENSFLKVNQKEKVRLLVIERSYNSVGNFLKKYIGEFFSITNFDELDCLTIDLVEIEKQYDVIVTDVMVGKSEELEIFFFYKMIPEAIIDRLNEFLNVSFTDNNVMVKNLEAPSPSKSHSDKEVQKPEKPDNSVKQATSATSS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008).
References
Luo et al., 2008: Luo F, Lizano S, Banik S, Zhang H, Bessen DE. Role of Mga in group A streptococcal infection at the skin epithelium. Microbial pathogenesis. 2008; 45(3); 217-224. [PubMed: 18588968].