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lsp from Streptococcus pyogenes NZ131

Victor ID 4444
Gene Name lsp from Streptococcus pyogenes NZ131
Sequence Strain (Species/Organism) Streptococcus pyogenes NZ131
NCBI Gene ID 6985658
NCBI Protein GI 209559191
Locus Tag Spy49_0647
Protein Accession YP_002285663.1
Other Database IDs UniProtKB-ID: B5XKV6_STRPZ
UniRef100: UniRef100_Q1JHH8
UniRef90: UniRef90_Q1JCF3
UniRef50: UniRef50_Q5M0X5
UniParc: UPI0000D75131
EMBL: CP000829
EMBL-CDS: ACI60968.1
RefSeq_NT: NC_011375.1
EnsemblGenome: EBSTRG00000049612.
EnsemblGenome_TRS: EBSTRT00000049620
EnsemblGenome_PRO: EBSTRP00000059251
GenomeReviews: CP000829_GR
KEGG: soz:Spy49_0647
HOGENOM: HBG724422
OMA: DGAGWQR
ProtClustDB: PRK14797
Taxonomy ID 471876
Gene Starting Position 649757
Gene Ending Position 650215
Gene Strand (Orientation) +
Protein Name lipoprotein signal peptidase
DNA Sequence 
>gi|209558587:649757-650215 Streptococcus pyogenes NZ131 chromosome, complete genome
CATGAAAAAACGATTGTTTGTGCTTAGCTTGATCCTCCTTGTAGCTTTGGATCAACTTAGTAAATTTTGG
ATTGTTTCTCATATAGCGCTTGGAGAAGTGAAACCCTTTATCCCAGGTATCGTCAGCTTGACTTACTTGC
AAAACAATGGGGCTGCCTTTTCCATATTGCAGGACCAGCAATGGTTCTTTGTTGTCATAACGGTTTTAGT
TATCGGTTATGCTATTTATTACCTTGCTACTCATCCCCATTTAAATATCTGGAAGCAATTAGCTCTCTTG
CTTATTATTTCTGGTGGAATCGGGAATTTTATTGATCGTTTGCGTTTAGCTTACGTGATTGATATGATTC
ATTTAGACTTTATGGATTTTGCCATTTTTAATGTGGCAGATTCATACCTTACCGTTGGTGTCATATTATT
AGTGATATGTTTATGGAAAGAAGAGGATTATGGAAATTA
Protein Sequence 
>gi|209559191|ref|YP_002285663.1| lipoprotein signal peptidase [Streptococcus pyogenes NZ131] MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMIHLDFMDFAIFNVADSYLTVGVILLVICLWKEEDYGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weston et al., 2009: Weston BF, Brenot A, Caparon MG. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity. 2009; 77(7); 2840-2848. [PubMed: 19398546].