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spyM18_1239

Victor ID 4313
Gene Name spyM18_1239
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS8232
NCBI Gene ID 993646
NCBI Protein GI 19746214
Locus Tag spyM18_1239
Protein Accession NP_607350.1
Other Database IDs UniProtKB-ID: Q8P0R9_STRP8
UniRef100: UniRef100_Q8P0R9
UniRef90: UniRef90_Q8L3E1
UniRef50: UniRef50_Q1CQ63
UniParc: UPI00000D9972
EMBL: AE009949
EMBL-CDS: AAL97849.1
RefSeq_NT: NC_003485.1
HSSP: P13380
EnsemblGenome: EBSTRG00000030432.
EnsemblGenome_TRS: EBSTRT00000030432
EnsemblGenome_PRO: EBSTRP00000029354
GenomeReviews: AE009949_GR
KEGG: spm:spyM18_1239
HOGENOM: HBG697988
OMA: SHFDVYL
ProtClustDB: CLSK449847
BioCyc: SPYO186103:SPYM18_1239-MONOMER
Taxonomy ID 186103
Gene Starting Position 1042685
Gene Ending Position 1043398
Gene Strand (Orientation) -
Protein Name putative exotoxin precursor (SpeM)
DNA Sequence 
>gi|19745201:1042685-1043398 Streptococcus pyogenes MGAS8232, complete genome
ACTAATTTTTAGAAAAATCTTCGTTTAAGTAAACATCAAAGTGACTTACTTTACTCATATCAATCGTTTC
ATTATCTGTATAGTTAGGATGAGTGAATAAATCGGTAAACTTTGTTGTATTATCTTTATAATGAATTCCC
CAATACCCTTTTTTACAAATTGAGTTATGTTCATATAACTTTATTCTATTATCGCTCATCAAACTTTTCC
TAAGTCTAACATCAATTTCTTGAAAAGTTACAAACTTATTCTGAAATGTGATTTTATATTTTGATTGCTC
TTTTAGCGGTATCTGTTCCCCAAAAATATTCATATATATTGTTGAATCAAGTTTCTCTCTGTCACTTGTT
CTTATCAAACCTCCATCAACATAATTATATTGTTCCTTACATATCACACTGTAGGATTTTATTAGAGCAT
AAATATCAACTTCTTCTTCCTTAAAGCGTCTTTCTTGCGCTGGAGAAACATTGCTAGATATAACTTTATT
ATAATTATCATCGTCCCAGACTCTAGTTTTTTCATTCGTGTTAAATATTAACTGGGTGCCAATTTTCTTT
GTTATCTTCATATTGGTTCTATTAATTACATCTTTCGTATAGATATTTTTTAATTCGCTATTAACCAACA
CAGCATCTGAAAAGACACTCTCAGTAGTGTATAGAGCAAGCGATACACACACAAGGAATAACAAAGTCAA
GGTATTTTTTTTCA
Protein Sequence 
>gi|19746214|ref|NP_607350.1| exotoxin SpeM [Streptococcus pyogenes MGAS8232] MKKNTLTLLFLVCVSLALYTTESVFSDAVLVNSELKNIYTKDVINRTNMKITKKIGTQLIFNTNEKTRVWDDDNYNKVISSNVSPAQERRFKEEEVDIYALIKSYSVICKEQYNYVDGGLIRTSDREKLDSTIYMNIFGEQIPLKEQSKYKITFQNKFVTFQEIDVRLRKSLMSDNRIKLYEHNSICKKGYWGIHYKDNTTKFTDLFTHPNYTDNETIDMSKVSHFDVYLNEDFSKN
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: Purified SpeM is pyrogenic and mitogenic for rabbit splenocytes and human peripheral blood mononuclear cells in picogram amounts. SpeM was lethal in one model of streptococcal toxic shock (Smoot et al., 2002).
References
Smoot et al., 2002: Smoot LM, McCormick JK, Smoot JC, Hoe NP, Strickland I, Cole RL, Barbian KD, Earhart CA, Ohlendorf DH, Veasy LG, Hill HR, Leung DY, Schlievert PM, Musser JM. Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks. Infection and immunity. 2002; 70(12); 7095-7104. [PubMed: 12438391].