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SPy_1718

Victor ID 4284
Gene Name SPy_1718
Sequence Strain (Species/Organism) Streptococcus pyogenes M1 GAS
NCBI Gene ID 901955
NCBI Protein GI 15675569
Locus Tag SPy_1718
Genbank Accession AE004092
Protein Accession NP_269743
Other Database IDs UniProtKB-ID: Q99YG3_STRP1
UniRef100: UniRef100_Q99YG3
UniRef90: UniRef90_C5WIQ5
UniRef50: UniRef50_B4U1F1
UniParc: UPI00000C7E83
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK34464.1
EMBL-CDS: AAZ52025.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000001220.
EnsemblGenome_TRS: EBSTRT00000001220
EnsemblGenome_PRO: EBSTRP00000001220
EnsemblGenome: EBSTRG00000028314.
EnsemblGenome_TRS: EBSTRT00000028314
EnsemblGenome_PRO: EBSTRP00000027332
GenomeReviews: AE004092_GR
HOGENOM:
Taxonomy ID 160490
Gene Starting Position 1423104
Gene Ending Position 1424090
Gene Strand (Orientation) +
Protein Name putative esterase
Protein pI 8.15
Protein Weight 36170.59
Protein Length 328
Protein Note Best Blastp hit = gb|AAF87664.1|AF223647_1 (AF223647) esterase [uncultured bacterium]
DNA Sequence 
>gi|15674250:1423104-1424090 Streptococcus pyogenes M1 GAS chromosome, complete genome
CTTGAAACATCCTATTCGAAAAACACTTGTCACCTTAGGTCTATTACTGACCTTATGCCTGCCGACTCCA
GTTGCAGCTAGTTCTCGTTCTTGGAAGAGCTGGTTTATCGAGCAATATTTCTGGTTAAAACGTGACAAGA
GTTACTATTCTAAACAAGATGACCCAAGCTTCCAAAGATACCTTGATGCCTGTCGTGAACAATCTGATAA
ACCTTATCAACTAGATACTAATTTAGTCAATGGTCCCCTTGTTCAAGAAAATCTTTATGGCATGCAGGTT
TACTCTTGGAATGATAATGGAAAACCTGATCAAAAAACAATTATTTATCTTGCCGGTGGTTCTTATCTTA
ACAATCCAACGACATACCATATTAATATGTTAAAGACATTATCCACAAGTCTTGACGCTAAAATTGTTTT
ACCCATTTATCCTAAAGCCCCACGTTATACCTATAACTATACTATGCCAAAATTGGTCAATCTTTACCAA
CACTATTACCATAAAAATCAGAATGTTTTCCTTATGGGAGATTCAGCAGGTGGAGGTTTAGCCTTAGGTC
TAGCTCATGCCCTACACAATGAATCAGTCCCTCAACCAAAGCAGCTCGTTCTTTTATCACCTTGGTTAGA
TGTTACTATGTCACACCCAGAGATTCCAGAATACGAAGATGCTGATCCTATTCTATCTTCTTGGGGATTA
AAACGAGTGGGAGAATTGTGGGCCTACTCTGCTGATAATACCAACCATATTTATGTCAGTCCTAAAAATG
GTCCGATCACTTATCTACCACCAATTACTTTATTTACTGGGACACGAGAGATCTTTTATCCTGATATTCG
CGATTATGCCGCAAAACTGAAAGCCGCTAACCACAATATTACCTTTATTACCCAAGAAGGCATGAACCAC
GTTTACCCAATTTATCCTATCGAAGAGGCAAAAACAGCTCAATACCAAATCATTGATGCCATCAACAAAA
CTCCTTA
Protein Sequence 
>gi|15675569|ref|NP_269743.1| putative esterase [Streptococcus pyogenes M1 GAS]
MKHPIRKTLVTLGLLLTLCLPTPVAASSRSWKSWFIEQYFWLKRDKSYYSKQDDPSFQRYLDACREQSDK
PYQLDTNLVNGPLVQENLYGMQVYSWNDNGKPDQKTIIYLAGGSYLNNPTTYHINMLKTLSTSLDAKIVL
PIYPKAPRYTYNYTMPKLVNLYQHYYHKNQNVFLMGDSAGGGLALGLAHALHNESVPQPKQLVLLSPWLD
VTMSHPEIPEYEDADPILSSWGLKRVGELWAYSADNTNHIYVSPKNGPITYLPPITLFTGTREIFYPDIR
DYAAKLKAANHNITFITQEGMNHVYPIYPIEEAKTAQYQIIDAINKTP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SPy_1718 (sse) mutant is attenuated in mice (Zhu et al., 2009).
COG COG0657I, under I: Lipid transport and metabolism
References
Zhu et al., 2009: Zhu H, Liu M, Sumby P, Lei B. The secreted esterase of group a streptococcus is important for invasive skin infection and dissemination in mice. Infection and immunity. 2009; 77(12); 5225-5232. [PubMed: 19805529].