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mga from Streptococcus pyogenes MGAS8232

Victor ID 4315
Gene Name mga from Streptococcus pyogenes MGAS8232
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS8232
NCBI Gene ID 994370
NCBI Protein GI 19746912
Locus Tag spyM18_2077
Protein Accession NP_608048.1
Other Database IDs UniProtKB-ID: Q8NZ78_STRP8
UniRef100: UniRef100_Q8NZ78
UniRef90: UniRef90_Q1J4H5
UniRef50: UniRef50_P19401
UniParc: UPI00000D9B33
EMBL: AE009949
EMBL-CDS: AAL98547.1
RefSeq_NT: NC_003485.1
EnsemblGenome: EBSTRG00000030894.
EnsemblGenome_TRS: EBSTRT00000030894
EnsemblGenome_PRO: EBSTRP00000029816
GenomeReviews: AE009949_GR
KEGG: spm:spyM18_2077
HOGENOM: HBG698420
OMA: NWIHLLD
ProtClustDB: CLSK443224
BioCyc: SPYO186103:SPYM18_2077-MONOMER
Taxonomy ID 186103
Gene Starting Position 1740876
Gene Ending Position 1742477
Gene Strand (Orientation) -
Protein Name positive regulatory protein Mga
DNA Sequence 
>gi|19745201:1740876-1742477 Streptococcus pyogenes MGAS8232, complete genome
CCTATGATGATGTTGCTTGTTTAACTGAATTGTCTGGCTTTTCTGGCTTTTGTACCTCTTTGTCACTATG
AGATTTTGAAGAGGAAGGGGCTTCGAGGTTTTTGACCATAACATTGTTATCTGTGAAACTAACGTTCAAA
AATTCGTTTAATCTATCAATAATAGCTTCTGGGATCATCTTGTAGAAAAAGAAAATCTCTAACTCTTCGC
TTTTACCCACCATAACATCTGTCACGATAACATCGTACTGTTTTTCAATCTCTACTAGATCAATTGTCAA
ACAATCTAACTCATCAAAATTAGTAATGCTGAAAAACTCACCGATGTACTTTTTCAAAAAATTACCGACA
CTATTGTAACTTCTCTCTATCACTAGAAGTCTTACTTTTTCATCTTTTTGATTTACTTTTAAGAAACTAT
TTTCCCAGGTAATAAAGAAACAATAAGTGAGCTGATTGATCAATTCTTTGCTAACTTGAGCATTATCTGC
CTGCATCAGCTTCTCGACACTTGTCACAAAGGCCTCATAGATACGAGGGTGTTCTTTTTGGTAAAAGTTC
AGGTAACTCTTTTTATAATCAAACAGCAAATAATTGGCTGTAATGTCTTCTTCGTTTAACACCGAAGCGT
TATGGAGGGTTACAGCAACTTCGTATTTATTGGTGATGCTGAGATTGAGCTTGATTTCCATCTCATCTAA
TAGATGGATCCAGTTGGTTACTTGTCTGCCTCCTGATGTTGGGTCTTGATTGATAATCTCAAAAGCACAG
CCAATTTCTAGCTTGTCGTTAAGATGGTTAGAAAACATTTCAGCTATGGTATACTCGTCGAGATGTAACC
CAAATTTGAGGTAGAACAAGCGAGAAAGATCCTGGATTTCTGAGTAATGTTGGATGAGTTGAGAAAAACG
GTGACTGGTTTTTTTATTGTTATAACTGCAAGAATACCCCTTGTAGTAACGGATCAAGTTGACACCACTT
AAGATTTTTAAGTGCTGAAATAGTGTAAAATGAACTTTGACATCTACTTCTTTGATCAATAAGCTCAATA
GGCGTTCACAGTTTTTCAGGTTTAAAATGTCCCCAAATGGCCATTCTGAGATTTTATAGGCTTCTGAAAA
ATACTTGAGGTAAAACAGGCGGATTTGCCTCTCATCTCCTGACACCTGCACTGGACTTGTCACGATACTA
ATAGCAAAGGTATGAGACAAGTAAGTGTTGGTTTTTTTGATGAGGCGTTTGAGGGTAGATAAACTGACAA
ACAGCTCTTCAGCTAACTCTTCTAAGGAACTAAAGTCTCTGAAAAACAAAAGCTCCAGTAATTTCAAAGA
AGGCGATTCTCGAAGAGCTTTTTGATAGACCTCTTGTAGCCCACAACACTGGTGATACCAAATGTTAATA
TAGCCGTCTTTGTAGGTAATTCCACCTACTTCTTTCATAAACTGCATATTAGTGAGGCATGACTGTAATG
TTAACATGGAAATATTGAGAGCCTTGCTAAGCTCCTTATCTTTAACTCCGATAGCATTGGAGTTTTCTGT
TAAATATGAGATCAGTTTCAATTCTCTCCATTGTTGGCTAGTAAACAATTTACTTACATGCA
Protein Sequence 
>gi|19746912|ref|NP_608048.1| positive regulatory protein Mga [Streptococcus pyogenes MGAS8232] MHVSKLFTSQQWRELKLISYLTENSNAIGVKDKELSKALNISMLTLQSCLTNMQFMKEVGGITYKDGYINIWYHQCCGLQEVYQKALRESPSLKLLELLFFRDFSSLEELAEELFVSLSTLKRLIKKTNTYLSHTFAISIVTSPVQVSGDERQIRLFYLKYFSEAYKISEWPFGDILNLKNCERLLSLLIKEVDVKVHFTLFQHLKILSGVNLIRYYKGYSCSYNNKKTSHRFSQLIQHYSEIQDLSRLFYLKFGLHLDEYTIAEMFSNHLNDKLEIGCAFEIINQDPTSGGRQVTNWIHLLDEMEIKLNLSITNKYEVAVTLHNASVLNEEDITANYLLFDYKKSYLNFYQKEHPRIYEAFVTSVEKLMQADNAQVSKELINQLTYCFFITWENSFLKVNQKDEKVRLLVIERSYNSVGNFLKKYIGEFFSITNFDELDCLTIDLVEIEKQYDVIVTDVMVGKSEELEIFFFYKMIPEAIIDRLNEFLNVSFTDNNVMVKNLEAPSSSKSHSDKEVQKPEKPDNSVKQATSS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008).
References
Luo et al., 2008: Luo F, Lizano S, Banik S, Zhang H, Bessen DE. Role of Mga in group A streptococcal infection at the skin epithelium. Microbial pathogenesis. 2008; 45(3); 217-224. [PubMed: 18588968].